ES8405368A1 - Un procedimiento para preparar una beta-lactama. - Google Patents

Un procedimiento para preparar una beta-lactama.

Info

Publication number
ES8405368A1
ES8405368A1 ES521479A ES521479A ES8405368A1 ES 8405368 A1 ES8405368 A1 ES 8405368A1 ES 521479 A ES521479 A ES 521479A ES 521479 A ES521479 A ES 521479A ES 8405368 A1 ES8405368 A1 ES 8405368A1
Authority
ES
Spain
Prior art keywords
alkyl
phenyl
substituted
substituted phenyl
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES521479A
Other languages
English (en)
Other versions
ES521479A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ER Squibb and Sons LLC
Original Assignee
ER Squibb and Sons LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC
Publication of ES8405368A1 publication Critical patent/ES8405368A1/es
Publication of ES521479A0 publication Critical patent/ES521479A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/085—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a nitrogen atom directly attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR UNA BETA-LACTAMA.CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA (III), Y EL COMPUESTO ASI OBTENIDO SE LE HACE REACCIONAR CON UNA AMINA DE FORMULA (IV), PARA OBTENER BETA-LACTAMA DE FORMULA (I) O UNA SAL DE LA MISMA, DONDE R ES -NRARB; RA Y RB SON IGUALES O DIFERENTES Y SIGNIFICAN HIDROGENO, ALCOHILO, FENILO, FENILALCOHILO Y OTROS; R1 ES AMINO, AMINO PROTEGIDO O ACILAMINO; R2 ES HIDROGENO O METOXI; R3 Y R4 SON IGUALES O DIFERENTES Y SIGNIFICAN HIDROGENO, ALCOHILO, CICLOALCOHILO, FENILO O FENILO SUSTITUIDO; Z ES OXIGENOO AZUFRE; E Y ES UN GRUPO ELIMINABLE TAL COMO HALOGENO.TIENE APLICACION FARMACOLOGICA COMO AGENTES ANTIBACTERIANOS POR EXHIBIR ACTIVIDAD CONTRA UNA GAMA DE BACTERIAS GRAM-NEGATIVAS Y GRAM-POSITIVAS.
ES521479A 1981-04-09 1983-04-15 Un procedimiento para preparar una beta-lactama. Granted ES521479A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US25267281A 1981-04-09 1981-04-09

Publications (2)

Publication Number Publication Date
ES8405368A1 true ES8405368A1 (es) 1984-06-01
ES521479A0 ES521479A0 (es) 1984-06-01

Family

ID=22957021

Family Applications (3)

Application Number Title Priority Date Filing Date
ES511238A Granted ES511238A0 (es) 1981-04-09 1982-04-07 "un procedimiento para preparar una beta-lactama".
ES521480A Expired ES8405369A1 (es) 1981-04-09 1983-04-15 Un procedimiento para preparar una beta-lactama.
ES521479A Granted ES521479A0 (es) 1981-04-09 1983-04-15 Un procedimiento para preparar una beta-lactama.

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES511238A Granted ES511238A0 (es) 1981-04-09 1982-04-07 "un procedimiento para preparar una beta-lactama".
ES521480A Expired ES8405369A1 (es) 1981-04-09 1983-04-15 Un procedimiento para preparar una beta-lactama.

Country Status (16)

Country Link
EP (1) EP0062876B1 (es)
JP (1) JPS57179156A (es)
AT (1) ATE22439T1 (es)
AU (1) AU561650B2 (es)
CA (1) CA1246572A (es)
DE (1) DE3273405D1 (es)
DK (1) DK162582A (es)
ES (3) ES511238A0 (es)
GR (1) GR76486B (es)
HU (1) HU187568B (es)
IE (1) IE52938B1 (es)
IL (1) IL65407A0 (es)
NZ (1) NZ199981A (es)
PH (1) PH23122A (es)
PT (1) PT74730B (es)
ZA (1) ZA821768B (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1272726C (en) * 1982-01-04 1990-08-14 2-oxo-1-(aminocarbonylaminosulfonyl- aminocarbonyl)azetidines
US4548747A (en) * 1983-05-02 1985-10-22 E. R. Squibb & Sons, Inc. 3-Acylamino-1-sulfonylaminocarbonylmethoxy-2-azetidinones
US4534896A (en) * 1983-06-13 1985-08-13 E. R. Squibb & Sons, Inc. 3-Acylamino-2-oxoazetidine-1-(β-oxopropionic acid)
US4587051A (en) * 1983-07-18 1986-05-06 E. R. Squibb & Sons, Inc. Desulfonation process for preparing 2-azetidinones
US4584132A (en) * 1983-08-09 1986-04-22 Hoffmann-La Roche Inc. 1-(N-phosphinylcarbamoyl) β-lactam antibacterial agents
US4576749A (en) * 1983-10-03 1986-03-18 E. R. Squibb & Sons, Inc. 3-Acylamino-1-carboxymethylaminocarbonyl-2-azetidinones
US4559335A (en) * 1983-10-03 1985-12-17 E. R. Squibb & Sons, Inc. 3-Acylamino-1-carboxymethyloxy (or thio) carbonyl-2-azetidinones
US4831130A (en) * 1984-05-31 1989-05-16 Hoffmann-La Roche Inc. β-lactam antibacterial agents
US4743685A (en) * 1985-09-26 1988-05-10 E. R. Squibb & Sons, Inc. 2-oxo-1-[[(substituted sulfonyl)amino]carbonyl]azetidines
EG18314A (en) * 1985-09-26 1993-02-28 Squibb & Sons Inc Process for preparing of 2-oxo-1((substituted sulfonyl)amino)carbonyl)-azitidines
EP0246786A1 (en) * 1986-05-23 1987-11-25 The Upjohn Company N-1 subsituted sulfonylaminocarbonyl, C-4 substituted monobactams
US4801705A (en) * 1986-06-23 1989-01-31 E. R. Squibb & Sons, Inc. 2-oxo-1-(((substituted sulfonyl)amino)-carbonyl)azetidines
CA1317298C (en) * 1987-03-03 1993-05-04 Upjohn Company (The) Antibiotic sulfonylaminocarbonyl activated .beta.-lactams
US4772693A (en) * 1987-07-01 1988-09-20 E. R. Squibb & Sons, Inc. 2-oxo-1-((Substituted sulfonyl)amino)-carbonyl)azetidines
US4762922A (en) * 1987-07-01 1988-08-09 Squibb Corporation 2-oxo-1-[[(substituted sulfonyl)amino]-carbonyl]azetidines
US4777252A (en) * 1987-08-13 1988-10-11 E. R. Squibb & Sons, Inc. 2-oxo-1-[[(substituted sulfonyl)amino]-carbonyl]azetidines
FI20031113A (fi) * 2003-07-29 2005-01-30 Outokumpu Oy Menetelmä ja laitteisto leijupetiuunin arinalta poistettavan materiaalin jäähdyttämiseksi
WO2005063704A1 (ja) * 2003-12-25 2005-07-14 Ono Pharmaceutical Co., Ltd. アゼチジン環化合物およびその医薬
ATE529111T1 (de) 2005-12-07 2011-11-15 Basilea Pharmaceutica Ag Nützliche monobactam-antibiotika
AU2012233003B2 (en) * 2005-12-07 2014-12-18 Basilea Pharmaceutica Ag Useful combinations of monobactam antibiotics with beta-lactamase inhibitors
CA2744756C (en) 2008-12-19 2013-05-28 Pfizer Inc. Monocarbams and their use as antibacterial agent
EP4251142A1 (en) 2020-11-30 2023-10-04 Sophrosyne Pharmaceuticals Limited Compounds and methods for treating alcohol use disorder

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2559307C2 (de) * 1975-12-31 1984-05-24 Rheinhold & Mahla Gmbh, 6800 Mannheim Verfahren und Vorrichtung zum Verkleben zweier Materialbahnen
US4195021A (en) * 1977-10-26 1980-03-25 Eli Lilly And Company 1,3-Disubstituted 2-azetidinone antibitotics
DE3069587D1 (en) * 1979-06-08 1984-12-13 Takeda Chemical Industries Ltd 1-sulpho-2-oxoazetidine derivatives, their production and pharmaceutical compositions thereof

Also Published As

Publication number Publication date
PH23122A (en) 1989-05-05
JPH0372616B2 (es) 1991-11-19
ES8307741A1 (es) 1983-07-01
IE52938B1 (en) 1988-04-13
ES521480A0 (es) 1984-06-01
IL65407A0 (en) 1982-07-30
IE820781L (en) 1982-10-09
NZ199981A (en) 1985-08-16
DK162582A (da) 1982-10-10
ES511238A0 (es) 1983-07-01
PT74730B (en) 1983-10-25
AU561650B2 (en) 1987-05-14
HU187568B (en) 1986-01-28
AU8155782A (en) 1982-10-14
CA1246572A (en) 1988-12-13
JPS57179156A (en) 1982-11-04
EP0062876A1 (en) 1982-10-20
ES8405369A1 (es) 1984-06-01
ZA821768B (en) 1983-01-26
GR76486B (es) 1984-08-10
PT74730A (en) 1982-05-01
EP0062876B1 (en) 1986-09-24
ATE22439T1 (de) 1986-10-15
ES521479A0 (es) 1984-06-01
DE3273405D1 (en) 1986-10-30

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970519