ES8405031A1 - Un procedimiento para la preparacion de antibioticos de fortimicina. - Google Patents

Un procedimiento para la preparacion de antibioticos de fortimicina.

Info

Publication number
ES8405031A1
ES8405031A1 ES521351A ES521351A ES8405031A1 ES 8405031 A1 ES8405031 A1 ES 8405031A1 ES 521351 A ES521351 A ES 521351A ES 521351 A ES521351 A ES 521351A ES 8405031 A1 ES8405031 A1 ES 8405031A1
Authority
ES
Spain
Prior art keywords
demethoxyfortimicin
deoxy
related compounds
incorporated
pharmaceutical compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES521351A
Other languages
English (en)
Other versions
ES521351A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of ES8405031A1 publication Critical patent/ES8405031A1/es
Publication of ES521351A0 publication Critical patent/ES521351A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/224—Cyclohexane rings substituted by at least two nitrogen atoms with only one saccharide radical directly attached to the cyclohexyl radical, e.g. destomycin, fortimicin, neamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE ANTIBIOTICOS DE FORTIMICINA, DE FORMULA (I), EN LA QUE R ES HIDROGENO O ALQUILO INFERIOR; R3 ES HIDROGENO O UN GRUPO PROTECTOR DE AMINO; Y R1, R2, R4, R5 Y R6 SON VARIOS TIPOS DE RADICALES.CONSISTE EN LA REACCION DE ACILACION DE 1,2,6-TRI-N-BENCILOXICARBONIL-2,3-ANHIDRO -3-DESMETOXIFORTIMICINA B, POR TRATAMIENTO CON N-(N-BENCILOXICARBONILGLICILOXI)SUCCINIMIDA, O CON OTROS AGENTES ACILANTES, EN UN DISOLVENTE INERTE; SEGUIDA DE LA HIDROGENACION CATALITICA DEL PRODUCTO FORMADO, CON HIDROGENO A 3 ATM EN PRESENCIA DE PD/C, EN UNA DISOLUCION DE ACIDO CLORHIDRICOEN METANOL.ESTOS ANTIBIOTICOS TIENEN APLICACIONES FARMACOLOGICAS COMO AGENTES ANTIBACTERIANOS.
ES521351A 1982-04-09 1983-04-08 Un procedimiento para la preparacion de antibioticos de fortimicina. Granted ES521351A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US36679982A 1982-04-09 1982-04-09

Publications (2)

Publication Number Publication Date
ES8405031A1 true ES8405031A1 (es) 1984-05-16
ES521351A0 ES521351A0 (es) 1984-05-16

Family

ID=23444568

Family Applications (1)

Application Number Title Priority Date Filing Date
ES521351A Granted ES521351A0 (es) 1982-04-09 1983-04-08 Un procedimiento para la preparacion de antibioticos de fortimicina.

Country Status (6)

Country Link
JP (1) JPS58188896A (es)
DE (1) DE3312677A1 (es)
ES (1) ES521351A0 (es)
FR (1) FR2524892A1 (es)
GB (1) GB2118179A (es)
IT (1) IT1164162B (es)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4251516A (en) * 1979-09-26 1981-02-17 Abbott Laboratories 2-Deoxy-3-O-Demethylfortimicins
US4250304A (en) * 1979-09-26 1981-02-10 Abbott Laboratories 2-Deoxy-2-substituted fortimicin A and B and derivatives
EP0040764B1 (en) * 1980-05-22 1983-07-20 Kowa Company, Ltd. Novel aminoglycosides, and antibiotic use thereof
JPS5785398A (en) * 1980-11-15 1982-05-28 Kowa Co Novel aminoglycoside and its preparation

Also Published As

Publication number Publication date
IT8320510A0 (it) 1983-04-08
FR2524892A1 (fr) 1983-10-14
DE3312677A1 (de) 1983-10-13
IT1164162B (it) 1987-04-08
JPS58188896A (ja) 1983-11-04
GB2118179A (en) 1983-10-26
ES521351A0 (es) 1984-05-16
GB8308760D0 (en) 1983-05-11

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