ES8403719A1 - "un metodo para preparar una suspension acuosa estabilizada de oxendolona". - Google Patents

"un metodo para preparar una suspension acuosa estabilizada de oxendolona".

Info

Publication number
ES8403719A1
ES8403719A1 ES515057A ES515057A ES8403719A1 ES 8403719 A1 ES8403719 A1 ES 8403719A1 ES 515057 A ES515057 A ES 515057A ES 515057 A ES515057 A ES 515057A ES 8403719 A1 ES8403719 A1 ES 8403719A1
Authority
ES
Spain
Prior art keywords
oxendolone
aqueous suspension
percent
suspension
injected
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES515057A
Other languages
English (en)
Other versions
ES515057A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of ES8403719A1 publication Critical patent/ES8403719A1/es
Publication of ES515057A0 publication Critical patent/ES515057A0/es
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

METODO DE PREPARACION DE SUSPENSIONES ACUOSAS ESTABILIZADAS DE OXENDOLONA Y DE SUS ESTERES.CONSISTE EN MEZCLAR CON AGUA 50 A 20 P/V DE PARTICULAS FINAMENTE DIVIDIDAS DE OXENDOLONA O DE UNO DE SUS ESTERES 0,05 A 1,0 DE UN AGENTE TENSOACTIVO NO IONICO, CUYO NUMERO HLB ESTA ENTRE 8 Y 18, Y DE 0,01-0,25 DE UN ESTER DE ACIDO P-HIDROXIBENZOICO, A UNA TEMPERATURA COMPRENDIDA ENTRE 10JC Y 40JC; Y AJUSTAR EL PH DE LA SUSPENSION FORMADA A UN VALOR 5,5 Y 7,0.ESTAS SUSPENSIONES TIENEN APLICACIONES FARMACOLOGICAS POR SU ACTIVIDAD ANTIANDROGENA.
ES515057A 1981-08-18 1982-08-17 "un metodo para preparar una suspension acuosa estabilizada de oxendolona". Granted ES515057A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP56129517A JPS5832899A (ja) 1981-08-18 1981-08-18 オキセンドロン水性懸濁剤

Publications (2)

Publication Number Publication Date
ES8403719A1 true ES8403719A1 (es) 1984-04-01
ES515057A0 ES515057A0 (es) 1984-04-01

Family

ID=15011450

Family Applications (1)

Application Number Title Priority Date Filing Date
ES515057A Granted ES515057A0 (es) 1981-08-18 1982-08-17 "un metodo para preparar una suspension acuosa estabilizada de oxendolona".

Country Status (13)

Country Link
US (1) US4462996A (es)
EP (1) EP0072662B1 (es)
JP (1) JPS5832899A (es)
KR (1) KR880001806B1 (es)
AR (1) AR230730A1 (es)
CA (1) CA1176983A (es)
DE (1) DE3263754D1 (es)
ES (1) ES515057A0 (es)
GR (1) GR76258B (es)
HK (1) HK23888A (es)
MY (1) MY8700654A (es)
PT (1) PT75435B (es)
SG (1) SG110187G (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4120311A1 (de) * 1991-06-20 1992-12-24 Kali Chemie Pharma Gmbh Konservierte pharmazeutische zubereitungen
US20050032811A1 (en) 2003-08-06 2005-02-10 Josiah Brown Methods for administering aripiprazole
ZA200602347B (en) 2003-10-23 2007-09-26 Otsuka Pharma Co Ltd Controlled release sterile injectable aripiprazole formulation and method
US20070148100A1 (en) * 2005-09-15 2007-06-28 Elan Pharma International, Limited Nanoparticulate aripiprazole formulations
CN101801342B (zh) * 2007-07-31 2012-07-11 大塚制药株式会社 制造阿立哌唑悬浮液和冻干制剂的方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2861920A (en) * 1954-05-04 1958-11-25 Upjohn Co Therapeutic suspensions of steroids containing pvp and/or pva
US3856829A (en) * 1970-01-07 1974-12-24 Takeda Chemical Industries Ltd 16{62 -hydrocarbon substituted estrane compounds
JPS4832643A (es) * 1971-09-02 1973-05-01
JPS4966815A (es) * 1972-10-25 1974-06-28

Also Published As

Publication number Publication date
CA1176983A (en) 1984-10-30
US4462996A (en) 1984-07-31
DE3263754D1 (en) 1985-06-27
KR880001806B1 (ko) 1988-09-19
KR840000901A (ko) 1984-03-26
GR76258B (es) 1984-08-04
JPS6361957B2 (es) 1988-11-30
AR230730A1 (es) 1984-06-29
SG110187G (en) 1988-05-20
JPS5832899A (ja) 1983-02-25
EP0072662A3 (en) 1983-08-24
HK23888A (en) 1988-04-08
EP0072662B1 (en) 1985-05-22
EP0072662A2 (en) 1983-02-23
PT75435B (pt) 1985-05-31
PT75435A (pt) 1982-09-01
MY8700654A (en) 1987-12-31
ES515057A0 (es) 1984-04-01

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20040916