ES8403318A1 - Procedimiento de preparacion de nuevos derivados de la benzodioxina y de sus sales de adicion acida. - Google Patents
Procedimiento de preparacion de nuevos derivados de la benzodioxina y de sus sales de adicion acida.Info
- Publication number
- ES8403318A1 ES8403318A1 ES519153A ES519153A ES8403318A1 ES 8403318 A1 ES8403318 A1 ES 8403318A1 ES 519153 A ES519153 A ES 519153A ES 519153 A ES519153 A ES 519153A ES 8403318 A1 ES8403318 A1 ES 8403318A1
- Authority
- ES
- Spain
- Prior art keywords
- processes
- preparation
- pharmaceutical compositions
- compositions containing
- benzodioxine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE LA BENZODIOXINA Y DE SUS SALES DE ADICION DE ACIDOS, DE FORMULA (I), EN LA QUE HET ES UN RADICAL HETEROCICLICO C5-6.CONSISTE EN LA REACCION DE CONDENSACION DE UN DERIVADO HALOGENADO DE FORMULA (II) CON UNA PIPERAZINA N-MONOSUSTITUIDA, DE FORMULA (III), EN LAS QUE HAL ES UN ATOMO DE CLORO O DE BROMO Y HET ES EL MISMO QUE EN LA FORMULA (I). LA REACCION SE EFECTUA EN UN DISOLVENTE POLAR, EN PRESENCIA DE UNA BASE COMO ACEPTOR DE HIDRACIDO, A UNA TEMPERATURA ENTRE 110JC Y 150JC.TAMBIEN SE PUEDE PARTIR DE OTRASSUSTANCIAS PARA EFECTUAR LA CONDENSACION O BIEN EFECTUAR UNA ALQUILACION REDUCTIVA DE UN ALDEHIDO ADECUADO.ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE TRASTORNOS PSICOTROPOS RELACIONADOS CON UNA DISFUNCION DE LAS VIAS DOPAMINERGICAS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8200870A FR2519986A1 (fr) | 1982-01-21 | 1982-01-21 | Nouveaux derives de benzodioxine, leurs procedes de preparation et les compositions pharmaceutiques les renfermant |
Publications (2)
Publication Number | Publication Date |
---|---|
ES519153A0 ES519153A0 (es) | 1984-03-16 |
ES8403318A1 true ES8403318A1 (es) | 1984-03-16 |
Family
ID=9270183
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES519153A Expired ES8403318A1 (es) | 1982-01-21 | 1983-01-20 | Procedimiento de preparacion de nuevos derivados de la benzodioxina y de sus sales de adicion acida. |
Country Status (14)
Country | Link |
---|---|
US (1) | US4613601A (es) |
EP (1) | EP0084993B1 (es) |
JP (1) | JPS58128384A (es) |
AT (1) | ATE14431T1 (es) |
AU (1) | AU553693B2 (es) |
CA (1) | CA1191850A (es) |
DE (1) | DE3360409D1 (es) |
ES (1) | ES8403318A1 (es) |
FR (1) | FR2519986A1 (es) |
IE (1) | IE54428B1 (es) |
NZ (1) | NZ202974A (es) |
OA (1) | OA07308A (es) |
PT (1) | PT76123B (es) |
ZA (1) | ZA83387B (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2557570B1 (fr) * | 1984-01-04 | 1986-04-18 | Adir | Nouveaux derives de la quinoleine, leur procede de preparation et les compositions pharmaceutiques les renfermant |
US4732311A (en) * | 1984-05-31 | 1988-03-22 | Nippondenso Co., Ltd. | Process of producing lightweight and corrosion-resistant heat exchanger |
FR2573075B1 (fr) * | 1984-09-14 | 1987-03-20 | Innothera Lab Sa | Nouvelles (pyridyl-2)-1 piperazines, leur procede de preparation et leur application en therapeutique |
US4701456A (en) * | 1984-09-19 | 1987-10-20 | Warner-Lambert Company | Aminoalkoxybenzopyranones as antipsychotic and anxiolytic agents |
US4812567A (en) * | 1985-10-16 | 1989-03-14 | American Home Products Corporation | Polycyclic spiroimides with psychotropic activity |
US4988699A (en) * | 1989-03-14 | 1991-01-29 | Warner-Lambert Company | Substituted tetrahydrobenzothiazoles as dopaminergic agents |
FR2664815B1 (fr) * | 1990-07-23 | 1994-11-04 | Adir | Systeme matriciel autoadhesif pour la liberation prolongee du piribedil par voie transcutanee. |
RU2118322C1 (ru) * | 1993-07-05 | 1998-08-27 | Дюфар Интернэшнл Рисерч Б.В. | 2,3-дигидро-1,4-бензодиокси-5-ил-пиперазиновые производные или их соли |
FR2724383B1 (fr) * | 1994-09-13 | 1996-10-18 | Synthelabo | Derives de 2-aminopyrimidine-4-carboxamide, leur preparation et leur application en therapeutique |
US6060472A (en) * | 1998-04-06 | 2000-05-09 | Apotex Inc. | Thiadiazole compounds useful as inhibitors of H+ /K+ atpase |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL127996C (es) * | 1963-11-19 | |||
US3362956A (en) * | 1965-08-19 | 1968-01-09 | Sterling Drug Inc | 1-[(heterocyclyl)-lower-alkyl]-4-substituted-piperazines |
GB1187680A (en) * | 1967-11-15 | 1970-04-15 | Science Union & Cie | New Heterocyclic Substituted Piperazines |
GB1369379A (en) * | 1972-04-07 | 1974-10-09 | Science Union & Cie | Benzodioxole derivatives and processes for preparing them |
GB1407552A (en) * | 1973-04-02 | 1975-09-24 | Science Union & Cie | Disubstituted piperazines processes for their preparation and pharmaceutical compositions containing them |
GB1518559A (en) * | 1976-04-12 | 1978-07-19 | Science Union & Cie | Naphthyl derivatives processes for their preparation an pharmaceutical compositions containing them |
GB1560084A (en) * | 1976-12-31 | 1980-01-30 | Science Union & Cie | Disubstituted piperazines processes for their preparation and pharmaceutical mompositions containing them |
-
1982
- 1982-01-21 FR FR8200870A patent/FR2519986A1/fr active Granted
-
1983
- 1983-01-07 NZ NZ202974A patent/NZ202974A/en unknown
- 1983-01-10 CA CA000419186A patent/CA1191850A/fr not_active Expired
- 1983-01-14 EP EP83400091A patent/EP0084993B1/fr not_active Expired
- 1983-01-14 AT AT83400091T patent/ATE14431T1/de not_active IP Right Cessation
- 1983-01-14 DE DE8383400091T patent/DE3360409D1/de not_active Expired
- 1983-01-20 ZA ZA83387A patent/ZA83387B/xx unknown
- 1983-01-20 ES ES519153A patent/ES8403318A1/es not_active Expired
- 1983-01-20 AU AU10659/83A patent/AU553693B2/en not_active Ceased
- 1983-01-20 PT PT76123A patent/PT76123B/pt unknown
- 1983-01-20 JP JP58008009A patent/JPS58128384A/ja active Pending
- 1983-01-21 IE IE116/83A patent/IE54428B1/en unknown
- 1983-01-21 OA OA57901A patent/OA07308A/xx unknown
-
1985
- 1985-01-22 US US06/693,278 patent/US4613601A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US4613601A (en) | 1986-09-23 |
JPS58128384A (ja) | 1983-07-30 |
ES519153A0 (es) | 1984-03-16 |
NZ202974A (en) | 1985-01-31 |
ZA83387B (en) | 1983-10-26 |
CA1191850A (fr) | 1985-08-13 |
EP0084993B1 (fr) | 1985-07-24 |
PT76123B (fr) | 1986-01-24 |
EP0084993A2 (fr) | 1983-08-03 |
IE54428B1 (en) | 1989-10-11 |
DE3360409D1 (en) | 1985-08-29 |
OA07308A (fr) | 1984-08-31 |
ATE14431T1 (de) | 1985-08-15 |
EP0084993A3 (en) | 1983-08-10 |
AU1065983A (en) | 1983-07-28 |
AU553693B2 (en) | 1986-07-24 |
IE830116L (en) | 1983-07-21 |
FR2519986B1 (es) | 1984-03-30 |
FR2519986A1 (fr) | 1983-07-22 |
PT76123A (fr) | 1983-02-01 |
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