ES8403318A1 - Procedimiento de preparacion de nuevos derivados de la benzodioxina y de sus sales de adicion acida. - Google Patents

Procedimiento de preparacion de nuevos derivados de la benzodioxina y de sus sales de adicion acida.

Info

Publication number
ES8403318A1
ES8403318A1 ES519153A ES519153A ES8403318A1 ES 8403318 A1 ES8403318 A1 ES 8403318A1 ES 519153 A ES519153 A ES 519153A ES 519153 A ES519153 A ES 519153A ES 8403318 A1 ES8403318 A1 ES 8403318A1
Authority
ES
Spain
Prior art keywords
processes
preparation
pharmaceutical compositions
compositions containing
benzodioxine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES519153A
Other languages
English (en)
Other versions
ES519153A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ADIR SARL
Original Assignee
ADIR SARL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ADIR SARL filed Critical ADIR SARL
Publication of ES8403318A1 publication Critical patent/ES8403318A1/es
Publication of ES519153A0 publication Critical patent/ES519153A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE LA BENZODIOXINA Y DE SUS SALES DE ADICION DE ACIDOS, DE FORMULA (I), EN LA QUE HET ES UN RADICAL HETEROCICLICO C5-6.CONSISTE EN LA REACCION DE CONDENSACION DE UN DERIVADO HALOGENADO DE FORMULA (II) CON UNA PIPERAZINA N-MONOSUSTITUIDA, DE FORMULA (III), EN LAS QUE HAL ES UN ATOMO DE CLORO O DE BROMO Y HET ES EL MISMO QUE EN LA FORMULA (I). LA REACCION SE EFECTUA EN UN DISOLVENTE POLAR, EN PRESENCIA DE UNA BASE COMO ACEPTOR DE HIDRACIDO, A UNA TEMPERATURA ENTRE 110JC Y 150JC.TAMBIEN SE PUEDE PARTIR DE OTRASSUSTANCIAS PARA EFECTUAR LA CONDENSACION O BIEN EFECTUAR UNA ALQUILACION REDUCTIVA DE UN ALDEHIDO ADECUADO.ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE TRASTORNOS PSICOTROPOS RELACIONADOS CON UNA DISFUNCION DE LAS VIAS DOPAMINERGICAS.
ES519153A 1982-01-21 1983-01-20 Procedimiento de preparacion de nuevos derivados de la benzodioxina y de sus sales de adicion acida. Granted ES519153A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8200870A FR2519986A1 (fr) 1982-01-21 1982-01-21 Nouveaux derives de benzodioxine, leurs procedes de preparation et les compositions pharmaceutiques les renfermant

Publications (2)

Publication Number Publication Date
ES8403318A1 true ES8403318A1 (es) 1984-03-16
ES519153A0 ES519153A0 (es) 1984-03-16

Family

ID=9270183

Family Applications (1)

Application Number Title Priority Date Filing Date
ES519153A Granted ES519153A0 (es) 1982-01-21 1983-01-20 Procedimiento de preparacion de nuevos derivados de la benzodioxina y de sus sales de adicion acida.

Country Status (14)

Country Link
US (1) US4613601A (es)
EP (1) EP0084993B1 (es)
JP (1) JPS58128384A (es)
AT (1) ATE14431T1 (es)
AU (1) AU553693B2 (es)
CA (1) CA1191850A (es)
DE (1) DE3360409D1 (es)
ES (1) ES519153A0 (es)
FR (1) FR2519986A1 (es)
IE (1) IE54428B1 (es)
NZ (1) NZ202974A (es)
OA (1) OA07308A (es)
PT (1) PT76123B (es)
ZA (1) ZA83387B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2557570B1 (fr) * 1984-01-04 1986-04-18 Adir Nouveaux derives de la quinoleine, leur procede de preparation et les compositions pharmaceutiques les renfermant
US4732311A (en) * 1984-05-31 1988-03-22 Nippondenso Co., Ltd. Process of producing lightweight and corrosion-resistant heat exchanger
FR2573075B1 (fr) * 1984-09-14 1987-03-20 Innothera Lab Sa Nouvelles (pyridyl-2)-1 piperazines, leur procede de preparation et leur application en therapeutique
US4701456A (en) * 1984-09-19 1987-10-20 Warner-Lambert Company Aminoalkoxybenzopyranones as antipsychotic and anxiolytic agents
US4812567A (en) * 1985-10-16 1989-03-14 American Home Products Corporation Polycyclic spiroimides with psychotropic activity
US4988699A (en) * 1989-03-14 1991-01-29 Warner-Lambert Company Substituted tetrahydrobenzothiazoles as dopaminergic agents
FR2664815B1 (fr) * 1990-07-23 1994-11-04 Adir Systeme matriciel autoadhesif pour la liberation prolongee du piribedil par voie transcutanee.
RU2118322C1 (ru) * 1993-07-05 1998-08-27 Дюфар Интернэшнл Рисерч Б.В. 2,3-дигидро-1,4-бензодиокси-5-ил-пиперазиновые производные или их соли
FR2724383B1 (fr) * 1994-09-13 1996-10-18 Synthelabo Derives de 2-aminopyrimidine-4-carboxamide, leur preparation et leur application en therapeutique
US6060472A (en) * 1998-04-06 2000-05-09 Apotex Inc. Thiadiazole compounds useful as inhibitors of H+ /K+ atpase

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL127996C (es) * 1963-11-19
US3362956A (en) * 1965-08-19 1968-01-09 Sterling Drug Inc 1-[(heterocyclyl)-lower-alkyl]-4-substituted-piperazines
GB1187680A (en) * 1967-11-15 1970-04-15 Science Union & Cie New Heterocyclic Substituted Piperazines
GB1369379A (en) * 1972-04-07 1974-10-09 Science Union & Cie Benzodioxole derivatives and processes for preparing them
GB1407552A (en) * 1973-04-02 1975-09-24 Science Union & Cie Disubstituted piperazines processes for their preparation and pharmaceutical compositions containing them
GB1518559A (en) * 1976-04-12 1978-07-19 Science Union & Cie Naphthyl derivatives processes for their preparation an pharmaceutical compositions containing them
GB1560084A (en) * 1976-12-31 1980-01-30 Science Union & Cie Disubstituted piperazines processes for their preparation and pharmaceutical mompositions containing them

Also Published As

Publication number Publication date
FR2519986A1 (fr) 1983-07-22
FR2519986B1 (es) 1984-03-30
DE3360409D1 (en) 1985-08-29
PT76123A (fr) 1983-02-01
ZA83387B (en) 1983-10-26
AU1065983A (en) 1983-07-28
EP0084993A2 (fr) 1983-08-03
US4613601A (en) 1986-09-23
ES519153A0 (es) 1984-03-16
IE54428B1 (en) 1989-10-11
JPS58128384A (ja) 1983-07-30
EP0084993A3 (en) 1983-08-10
CA1191850A (fr) 1985-08-13
PT76123B (fr) 1986-01-24
EP0084993B1 (fr) 1985-07-24
OA07308A (fr) 1984-08-31
ATE14431T1 (de) 1985-08-15
AU553693B2 (en) 1986-07-24
NZ202974A (en) 1985-01-31
IE830116L (en) 1983-07-21

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