ES8402836A3 - 4-Acyloxy-2H-1,2-benzothiazine-3-carboxamide 1,1-di:oxide(s) - Google Patents

4-Acyloxy-2H-1,2-benzothiazine-3-carboxamide 1,1-di:oxide(s)

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Publication number
ES8402836A3
ES8402836A3 ES519392A ES519392A ES8402836A3 ES 8402836 A3 ES8402836 A3 ES 8402836A3 ES 519392 A ES519392 A ES 519392A ES 519392 A ES519392 A ES 519392A ES 8402836 A3 ES8402836 A3 ES 8402836A3
Authority
ES
Spain
Prior art keywords
benzothiazine
carboxamide
methyl
pyridyl
dioxide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES519392A
Other languages
Spanish (es)
Other versions
ES519392A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Priority to ES519392A priority Critical patent/ES8402836A3/en
Publication of ES519392A0 publication Critical patent/ES519392A0/en
Publication of ES8402836A3 publication Critical patent/ES8402836A3/en
Expired legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

N-(2-Pyridyl)-4- acyloxy-2-methyl -2H-1,2- benzothiazine-3- carboxamide 1,1-dioxide derivs. of formula (I) are new (where R is 2-9C alkanoyl, benzoyl, toluoyl, thenoyl, furoyl, lower alkanesulphonyl or benzenesulphonyl; and R1 is H or CH3). - 7 Cpds. (I), e.g. N-(2-pyridyl)-2 -methyl-4- acetoxy-2H-1,2- benzothiazine-3 -carboxamide 1,1-dioxide and N-(6-methyl-2-pyridyl)-2 -methyl-4- methanesulphonyloxy- 2H-1,2- benzothiazine-3-carboxamide 1,1-dioxide are specifically claimed. - (I) are antiinflammatories, esp. active topically. Pref. doses are 0.16-16 mg/kg/day, by oral, parenteral or topical routes. Higher blood levels are obtd. after topical admin. than those of the 4-hydroxy-2H-1,2-benzothiazine-3-carboxamido 1,1-dioxides of US 3591584 (including piroxicam). EPAB- EP--57059 B Pharmaceutically active cpds have formula (I), where Q is R, are pref. produced by reacting a cpd. (I), where Q is H, with an acyl halide RX. In the formula R is 2-9C alkanoyl, benzoyl, toluoyl, furoyl, thenoyl, 1-6C alkane- or benzenesulphonyl; R' is H or Me. - (I) are highly effective anti-inflammatory agents esp. suitable for topical administration. (11pp)
ES519392A 1983-01-31 1983-01-31 4-Acyloxy-2H-1,2-benzothiazine-3-carboxamide 1,1-di:oxide(s) Expired ES8402836A3 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES519392A ES8402836A3 (en) 1983-01-31 1983-01-31 4-Acyloxy-2H-1,2-benzothiazine-3-carboxamide 1,1-di:oxide(s)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES519392A ES8402836A3 (en) 1983-01-31 1983-01-31 4-Acyloxy-2H-1,2-benzothiazine-3-carboxamide 1,1-di:oxide(s)

Publications (2)

Publication Number Publication Date
ES519392A0 ES519392A0 (en) 1984-03-01
ES8402836A3 true ES8402836A3 (en) 1984-03-01

Family

ID=8485269

Family Applications (1)

Application Number Title Priority Date Filing Date
ES519392A Expired ES8402836A3 (en) 1983-01-31 1983-01-31 4-Acyloxy-2H-1,2-benzothiazine-3-carboxamide 1,1-di:oxide(s)

Country Status (1)

Country Link
ES (1) ES8402836A3 (en)

Also Published As

Publication number Publication date
ES519392A0 (en) 1984-03-01

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