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National Research Development Corp UK
Wellcome Foundation Ltd
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National Research Development Corp UK
Wellcome Foundation Ltd
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Application filed by National Research Development Corp UK, Wellcome Foundation LtdfiledCriticalNational Research Development Corp UK
Publication of ES516673A0publicationCriticalpatent/ES516673A0/en
Publication of ES8400876A1publicationCriticalpatent/ES8400876A1/en
Preparation Of Compounds By Using Micro-Organisms
(AREA)
Peptides Or Proteins
(AREA)
Micro-Organisms Or Cultivation Processes Thereof
(AREA)
Abstract
DNA molecule comprising a nucleotide sequence corresp. to all or a portion of foot-and-mouth disease virus RNA (FMDV) is new. Recombinant DNA molecule comprises an operon having initiator sequences, terminator sequences and a nucleotide sequence coding for all or a part of at least one protein of FMDV, the nucleotide sequence being located between the initiator sequences and terminator sequences of the operon is new. Recombinant DNA cloning vehicle capable of expressing all or part of a protein of FMDV and comprising a recombinant DNA molecule as defined above is new. Host cell contg. at least one recombinant cloning vehicle as defined above is also new. The antigen produced by such a host cell is useful for stimulating prodn. of antibodies against FMDV in a mammal. Individual polypeptides equivalent to FMDV capsid proteins can be obtd., and serial synthesis of seVeral FMDV polypeptides as separate entities or as fusion prods. of parts of 2 or more proteins is achieved.
ES516673A1981-08-181982-10-20DNA corresp. to (part of) foot and mouth disease virus RNA
ExpiredES8400876A1
(en)
Polynucleotide, vector, cells, expressing system, polypeptides, monoclonal antibodies, preparation of polyclonal antibodies, nucleotide probe, analytic kits, method for detecting nucleic acids, methods for immunoassay, vaccine, method for production of antibodies
DNA fragments encoding non-A non-B hepatitis specific antigens, expression vectors containing the DNA fragments, transformants, and methods of preparing the antigens