ES8400753A1 - Un metodo de preparar 5,7-esteroides. - Google Patents

Un metodo de preparar 5,7-esteroides.

Info

Publication number
ES8400753A1
ES8400753A1 ES518921A ES518921A ES8400753A1 ES 8400753 A1 ES8400753 A1 ES 8400753A1 ES 518921 A ES518921 A ES 518921A ES 518921 A ES518921 A ES 518921A ES 8400753 A1 ES8400753 A1 ES 8400753A1
Authority
ES
Spain
Prior art keywords
alkanol
optionally
esterified
steroids
alkane carboxylic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES518921A
Other languages
English (en)
Other versions
ES518921A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Duphar International Research BV
Original Assignee
Duphar International Research BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Duphar International Research BV filed Critical Duphar International Research BV
Publication of ES8400753A1 publication Critical patent/ES8400753A1/es
Publication of ES518921A0 publication Critical patent/ES518921A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/005—Ketals
    • C07J21/006—Ketals at position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE D5,7-ESTEROIDES DEL TIPO DE DERIVADOS DE 7-DESHIDROCOLESTEROL, DE FORMULA (I), EN LA QUE R, R, R Y R PUEDEN SER VARIOS TIPOS DE RADICALES.CONSISTE EN LA REACCION DE DESHIDROBROMACION DE 7-BROMO-D5-ESTEROIDES. LA REACCION SE LLEVA A CABO EN UN DISOLVENTE ORGANICO INERTE APROTONICO, BAJO LA INFLUENCIA DE UNA BASE, TAL COMO UN FLUORURO DE METAL ALCALINO O ALCALINOTERREO O DE TETRA(HIDROCARBIL)-AMONIO, A UNA TEMPERATURA COMPRENDIDA ENTRE C10JC Y 120JC.ESTOS ESTEROIDES TIENEN APLICACIONES PARA EL TRATAMIENTO DE CASOS EN LOS QUE EXISTANPROBLEMAS CON EL METABOLISMO DEL CALCIO.
ES518921A 1982-01-14 1983-01-12 Un metodo de preparar 5,7-esteroides. Granted ES518921A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL8200128 1982-01-14

Publications (2)

Publication Number Publication Date
ES8400753A1 true ES8400753A1 (es) 1983-11-01
ES518921A0 ES518921A0 (es) 1983-11-01

Family

ID=19839079

Family Applications (1)

Application Number Title Priority Date Filing Date
ES518921A Granted ES518921A0 (es) 1982-01-14 1983-01-12 Un metodo de preparar 5,7-esteroides.

Country Status (9)

Country Link
US (1) US4464298A (es)
EP (1) EP0084199B1 (es)
JP (1) JPS58124800A (es)
AT (1) ATE26840T1 (es)
CA (1) CA1192184A (es)
DE (1) DE3276168D1 (es)
DK (1) DK165410C (es)
ES (1) ES518921A0 (es)
IL (1) IL67658A0 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1241947A (en) * 1985-05-31 1988-09-13 Pierre R. Proulx Conjugated polyene sterol derivatives as membrane probes
US5112998A (en) * 1987-03-30 1992-05-12 Kuraray Co., Ltd. Pregnane derivatives and processes for production thereof
DE3854089T2 (de) * 1988-07-05 1995-11-02 Kuraray Co Steroid-verbindungen.
KR20010043558A (ko) * 1998-05-13 2001-05-25 한센 핀 베네드, 안네 제헤르, 웨이콥 마리안느 감수분열 조절 화합물
CN101486748B (zh) * 2008-01-15 2011-11-02 浙江新和成股份有限公司 一种5，7-双烯胆固醇酯的制备方法
CN103314004B (zh) * 2011-12-02 2015-07-08 台州市海盛制药有限公司 5,7-孕甾二烯-3,20-二酮-二乙二缩酮新的制备方法
CN104237417B (zh) * 2014-09-30 2017-06-23 华润紫竹药业有限公司 一种地屈孕酮中间体的分析方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3032562A (en) * 1961-02-08 1962-05-01 Nopco Chem Co Process for the recovery of 7-dehydrosterols
JPS51122054A (en) * 1975-04-14 1976-10-25 Teijin Ltd A method for preparing 7- dehydrocholesterol
JPS51122053A (en) * 1975-04-14 1976-10-25 Teijin Ltd A process for preparing 3beta - hydroxycholesta-5,7-diene
JPS51122055A (en) * 1975-04-14 1976-10-25 Teijin Ltd A process for isolating 7- dehydtocholesterol
US4026882A (en) * 1976-03-08 1977-05-31 Hoffmann-La Roche Inc. Syntheses of 3,24R,25- and 3,24S,25-trihydroxy-5,7-cholestadiene 24,25-ketals and alkanoyl derivatives thereof
US4116985A (en) * 1976-07-26 1978-09-26 The Upjohn Company Novel method for preparing cholesta-5,7-diene 3β,25-diol and derivatives thereof

Also Published As

Publication number Publication date
CA1192184A (en) 1985-08-20
IL67658A0 (en) 1983-05-15
DK9083D0 (da) 1983-01-11
DK9083A (da) 1983-07-15
ATE26840T1 (de) 1987-05-15
DE3276168D1 (en) 1987-06-04
DK165410C (da) 1993-04-13
DK165410B (da) 1992-11-23
ES518921A0 (es) 1983-11-01
EP0084199A1 (en) 1983-07-27
US4464298A (en) 1984-08-07
EP0084199B1 (en) 1987-04-29
JPS58124800A (ja) 1983-07-25
JPH037678B2 (es) 1991-02-04

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