ES8308923A1 - Target cell lysis factor prodn. - Google Patents

Target cell lysis factor prodn.

Info

Publication number
ES8308923A1
ES8308923A1 ES514210A ES514210A ES8308923A1 ES 8308923 A1 ES8308923 A1 ES 8308923A1 ES 514210 A ES514210 A ES 514210A ES 514210 A ES514210 A ES 514210A ES 8308923 A1 ES8308923 A1 ES 8308923A1
Authority
ES
Spain
Prior art keywords
interferon
prodn
ebv
pref
cell lysis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES514210A
Other languages
Spanish (es)
Other versions
ES514210A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hayashibara Seibutsu Kagaku Kenkyujo KK
Original Assignee
Hayashibara Seibutsu Kagaku Kenkyujo KK
Hayashibara Biochemical Laboratories Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP56112913A external-priority patent/JPS5816687A/en
Priority claimed from JP56112914A external-priority patent/JPS5815921A/en
Priority claimed from JP56120459A external-priority patent/JPS5821621A/en
Priority claimed from JP56187626A external-priority patent/JPS5889195A/en
Application filed by Hayashibara Seibutsu Kagaku Kenkyujo KK, Hayashibara Biochemical Laboratories Co Ltd filed Critical Hayashibara Seibutsu Kagaku Kenkyujo KK
Publication of ES8308923A1 publication Critical patent/ES8308923A1/en
Publication of ES514210A0 publication Critical patent/ES514210A0/en
Granted legal-status Critical Current

Links

Abstract

Method for producing target-cell lysis factor (I) comprises treating an appropriate human cell line with a (I)-releasing agent (A), inducing (I)-prodn., then collecting and purifying the (I) formed. Pref. the cell line is multiplied by transplanting into a warm-blooded animal or is cultured in vitro in presence of body fluids from such an animal. Specified cell lines are BALL-1, Namalva, CCRF-SB, EBV, TALL-1, MOLT-3, NALL-1, MONO-1, JBL, EBV-MO and established cell lines of monocytic origin. Pref. (A) are interferon-alpha or -gamma releasing aegents, esp. phytohaemmagglutinin or concanavalin A, and the cells withwill then also produce human interferon. (I) is useful, opt. together with interferon, for treatment of malignant tumours. It can now be prepd. in large quantities and with high purity, using only small amts. of expensive serum-contg. culture media.
ES514210A 1981-07-21 1982-07-21 A PROCEDURE FOR THE PRODUCTION OF TCLF. Granted ES514210A0 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP56112913A JPS5816687A (en) 1981-07-21 1981-07-21 Preparation of lymphotoxin
JP56112914A JPS5815921A (en) 1981-07-21 1981-07-21 Preventing agent and remedy for lymphotoxin -sensitive disease
JP56120459A JPS5821621A (en) 1981-07-31 1981-07-31 Remedy for malignant tumor containing tnf (tumor necrosis factor)
JP56187626A JPS5889195A (en) 1981-11-21 1981-11-21 Preparation of target cell lysis factor

Publications (2)

Publication Number Publication Date
ES8308923A1 true ES8308923A1 (en) 1983-08-01
ES514210A0 ES514210A0 (en) 1983-08-01

Family

ID=27470041

Family Applications (1)

Application Number Title Priority Date Filing Date
ES514210A Granted ES514210A0 (en) 1981-07-21 1982-07-21 A PROCEDURE FOR THE PRODUCTION OF TCLF.

Country Status (1)

Country Link
ES (1) ES514210A0 (en)

Also Published As

Publication number Publication date
ES514210A0 (en) 1983-08-01

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20040601