Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Hayashibara Seibutsu Kagaku Kenkyujo KK
Original Assignee
Hayashibara Seibutsu Kagaku Kenkyujo KK
Hayashibara Biochemical Laboratories Co Ltd
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Filing date
Publication date
Priority claimed from JP56112913Aexternal-prioritypatent/JPS5816687A/en
Priority claimed from JP56112914Aexternal-prioritypatent/JPS5815921A/en
Priority claimed from JP56120459Aexternal-prioritypatent/JPS5821621A/en
Priority claimed from JP56187626Aexternal-prioritypatent/JPS5889195A/en
Application filed by Hayashibara Seibutsu Kagaku Kenkyujo KK, Hayashibara Biochemical Laboratories Co LtdfiledCriticalHayashibara Seibutsu Kagaku Kenkyujo KK
Publication of ES8308923A1publicationCriticalpatent/ES8308923A1/en
Publication of ES514210A0publicationCriticalpatent/ES514210A0/en
Method for producing target-cell lysis factor (I) comprises treating an appropriate human cell line with a (I)-releasing agent (A), inducing (I)-prodn., then collecting and purifying the (I) formed. Pref. the cell line is multiplied by transplanting into a warm-blooded animal or is cultured in vitro in presence of body fluids from such an animal. Specified cell lines are BALL-1, Namalva, CCRF-SB, EBV, TALL-1, MOLT-3, NALL-1, MONO-1, JBL, EBV-MO and established cell lines of monocytic origin. Pref. (A) are interferon-alpha or -gamma releasing aegents, esp. phytohaemmagglutinin or concanavalin A, and the cells withwill then also produce human interferon. (I) is useful, opt. together with interferon, for treatment of malignant tumours. It can now be prepd. in large quantities and with high purity, using only small amts. of expensive serum-contg. culture media.
ES514210A1981-07-211982-07-21
A PROCEDURE FOR THE PRODUCTION OF TCLF.
GrantedES514210A0
(en)
Lymphoblastoid cell lines capable of continuously and spontaneously producing interferon, process for preparing the same, and process for the human interferon production by the same