ES8306594A1 - Vaccine against brucellosis in humans - contg. phenol insoluble fraction of defatted Brucella abortus cells - Google Patents

Vaccine against brucellosis in humans - contg. phenol insoluble fraction of defatted Brucella abortus cells

Info

Publication number
ES8306594A1
ES8306594A1 ES512691A ES512691A ES8306594A1 ES 8306594 A1 ES8306594 A1 ES 8306594A1 ES 512691 A ES512691 A ES 512691A ES 512691 A ES512691 A ES 512691A ES 8306594 A1 ES8306594 A1 ES 8306594A1
Authority
ES
Spain
Prior art keywords
phenol
vaccine
esp
contg
humans
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES512691A
Other languages
Spanish (es)
Other versions
ES512691A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institut Merieux SA
Original Assignee
Institut Merieux SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institut Merieux SA filed Critical Institut Merieux SA
Publication of ES8306594A1 publication Critical patent/ES8306594A1/en
Publication of ES512691A0 publication Critical patent/ES512691A0/en
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/098—Brucella

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Vaccine against brucellosis comprises, in a suitable vehicle, the phenol-insoluble fraction (A) of Brucella abortus, esp. the strain B19. Pref. (A) is 1.7-2.3, esp. 2, mg (dry basis) per ml solvent and the vaccine is esp. formulated in unit doses of 0.5 ml. The pref. vehicle is a phenol-contg. physiological solvent. The vaccine is made from intact B.abortus cells by (1) removal of lipids (2) drying (3) extracting with phenol (esp. phenol satd. with water), at about 60 deg.C (4) washing the filtered and purified prod. and (5) forming into a homogeneous, sterile suspension. The vaccine is suitable for admin. to humans, e.g. farm workers or veterinary surgeons, and is effective against B. melitensis and B. suis as well as B. abortus. It is nontoxic and induces only very mild hypersensitivity reactions.
ES512691A 1981-06-01 1982-05-31 "PROCEDURE FOR PREPARING A VACCINE AGAINST BRUCELLOSIS". Granted ES512691A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8110789A FR2506615A1 (en) 1981-06-01 1981-06-01 Vaccine against brucellosis in humans - contg. phenol insoluble fraction of defatted Brucella abortus cells

Publications (2)

Publication Number Publication Date
ES8306594A1 true ES8306594A1 (en) 1983-06-01
ES512691A0 ES512691A0 (en) 1983-06-01

Family

ID=9259055

Family Applications (1)

Application Number Title Priority Date Filing Date
ES512691A Granted ES512691A0 (en) 1981-06-01 1982-05-31 "PROCEDURE FOR PREPARING A VACCINE AGAINST BRUCELLOSIS".

Country Status (7)

Country Link
AU (1) AU555214B2 (en)
ES (1) ES512691A0 (en)
FR (1) FR2506615A1 (en)
GR (1) GR76448B (en)
IL (1) IL65920A (en)
IT (1) IT1157306B (en)
PT (1) PT74968B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1227892B (en) * 1988-12-13 1991-05-14 Alberto Indrio PHARMACEUTICAL COMPOSITIONS WITH ANTI-PRESSURE AND ANXIOLYTIC ACTIVITY
IT1237538B (en) * 1989-12-22 1993-06-08 PHARMACEUTICAL COMPOSITIONS FOR DRUG DEPENDENCE THERAPY

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1056839A (en) * 1963-09-19 1967-02-01 Johnson & Johnson Brucella antigen
FR2035795A1 (en) * 1969-03-31 1970-12-24 Merieux Inst Anti-brucellosis vaccine prepn
GB1285057A (en) * 1969-05-28 1972-08-09 Secr Defence Improvements in brucellosis vaccines
GB1352125A (en) * 1970-07-16 1974-05-08 Wellcome Found Antigenic extracts
FR2287238A1 (en) * 1974-10-11 1976-05-07 Agronomique Inst Nat Rech Anti brucellosis vaccine - consisting of the covering or walls of brucella cells free from their cytoplasmic contents

Also Published As

Publication number Publication date
IT1157306B (en) 1987-02-11
PT74968A (en) 1982-06-01
IL65920A0 (en) 1982-08-31
PT74968B (en) 1984-08-02
IT8221603A0 (en) 1982-05-31
IL65920A (en) 1985-09-29
AU555214B2 (en) 1986-09-18
ES512691A0 (en) 1983-06-01
GR76448B (en) 1984-08-10
FR2506615B1 (en) 1984-10-26
FR2506615A1 (en) 1982-12-03
AU8432982A (en) 1982-12-09

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970505