ES8305378A1 - "procedimiento de obtencion de derivados tiolicos de la eritromicina y del ester propionico de la eritromicina". - Google Patents
"procedimiento de obtencion de derivados tiolicos de la eritromicina y del ester propionico de la eritromicina".Info
- Publication number
- ES8305378A1 ES8305378A1 ES510029A ES510029A ES8305378A1 ES 8305378 A1 ES8305378 A1 ES 8305378A1 ES 510029 A ES510029 A ES 510029A ES 510029 A ES510029 A ES 510029A ES 8305378 A1 ES8305378 A1 ES 8305378A1
- Authority
- ES
- Spain
- Prior art keywords
- erythromycin
- pharmaceutical compositions
- compositions containing
- therapeutic activity
- thiolic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
PROCEDIMIENTO DE OBTENCION DE DERIVADOS TIOLICOS DE LA ERITROMICINA Y DEL ESTER PROPIONICO DE LA ERITROMICINA. CONSISTE EN HACER REACCIONAR LA ERITROMICINA BASE O SU ESTER PROPIONICO CON UN ACIDO, EN UN DISOLVENTE TAL COMO LA ACETONA O LA METILISOBUTILCETONA A UNA TEMPERATURA COMPRENDIDA ENTRE 20 C Y 40 C EN PRESENCIA DE AGUA; LA CANTIDAD DE AGUA PRESENTE EN EL SOLVENTE, NO ES SUPERIOR AL 20% EN VOLUMEN DEL SOLVENTE DE REACCION, ESTANDO PREFERENTEMENTE COMPRENDIDA ENTRE 4 Y 5%. SE OBTIENEN COMPUESTOS DE FORMULA R-X EN QUE R ES EL RADICAL (I) Y X ES EL RADICAL DE LA ERITROMICINA (II).
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8200821A FR2519988B1 (fr) | 1982-01-20 | 1982-01-20 | Derives thioliques de l'erythromycine a activite therapeutique, procede de preparation et produits pharmaceutiques dans lesquels ils apparaissent |
Publications (2)
Publication Number | Publication Date |
---|---|
ES510029A0 ES510029A0 (es) | 1983-05-01 |
ES8305378A1 true ES8305378A1 (es) | 1983-05-01 |
Family
ID=9270148
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES510029A Expired ES8305378A1 (es) | 1982-01-20 | 1982-02-02 | "procedimiento de obtencion de derivados tiolicos de la eritromicina y del ester propionico de la eritromicina". |
Country Status (4)
Country | Link |
---|---|
US (1) | US4476120A (es) |
ES (1) | ES8305378A1 (es) |
FR (1) | FR2519988B1 (es) |
IT (1) | IT1193039B (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1173441B (it) * | 1984-03-14 | 1987-06-24 | Edmond Pharma Srl | Sali di eritromicina con derivati dell'acido acetico,procedimento per la loro preparazione e composizioni farmaceutiche che li contengono |
CA2164955A1 (en) * | 1993-06-18 | 1995-01-05 | Richard J. Sharpe | Method for treating hyperkeratosis and diseases mediated by proteases |
US5637616A (en) * | 1993-06-18 | 1997-06-10 | Arcturus Pharmaceutical Corporation | Method for treating diseases mediated by proteases |
GB2320431B (en) * | 1996-12-20 | 2000-08-30 | Johnson & Johnson Medical | Compositions for the treatment of chronic wounds |
CA2346870A1 (en) | 1998-10-20 | 2000-04-27 | Lauteral Limited | Derivatives of erythromycin, clarithromycin, roxithromycin or azithromycin with antibiotic and mucolytic activity |
AU775565B2 (en) * | 1999-10-29 | 2004-08-05 | Novartis Ag | Dry powder compositions having improved dispersivity |
US6566401B2 (en) * | 2001-03-30 | 2003-05-20 | The Board Of Trustees Of The Leland Stanford Junior University | N-acetylcysteine compositions and methods for the treatment and prevention of drug toxicity |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2653899A (en) * | 1952-04-14 | 1953-09-29 | Lilly Co Eli | Erythromycin, its salts, and method of preparation |
US2743268A (en) * | 1952-07-12 | 1956-04-24 | Lilly Co Eli | Erythromycin-penicillin |
US2830982A (en) * | 1955-06-03 | 1958-04-15 | Abbott Lab | Water-soluble salt of erythromycin |
US3558594A (en) * | 1968-09-04 | 1971-01-26 | Abbott Lab | Erythromycin aliphatic sulfate |
GB1250045A (en) * | 1969-01-15 | 1971-10-20 | Pierrel Spa | A new water soluble derivative of erythromycin |
US3847896A (en) * | 1973-04-09 | 1974-11-12 | Upjohn Co | Erythromycin-2-thiol esters and process |
DK139522C (da) * | 1975-04-07 | 1979-08-20 | Thomae Gmbh Dr K | Analogifremgangsmaade til fremstilling af 9-iminoalkylamino-erythromyciner eller syreadditionssalte deraf |
US4261982A (en) * | 1977-11-09 | 1981-04-14 | The Procter & Gamble Company | Therapeutic composition |
US4264765A (en) * | 1980-02-20 | 1981-04-28 | Abbott Laboratories | Salts of erythromycin A esters |
-
1982
- 1982-01-20 FR FR8200821A patent/FR2519988B1/fr not_active Expired
- 1982-02-02 IT IT19409/82A patent/IT1193039B/it active
- 1982-02-02 ES ES510029A patent/ES8305378A1/es not_active Expired
- 1982-02-02 US US06/344,960 patent/US4476120A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
FR2519988A1 (fr) | 1983-07-22 |
ES510029A0 (es) | 1983-05-01 |
IT8219409A0 (it) | 1982-02-02 |
IT1193039B (it) | 1988-06-02 |
US4476120A (en) | 1984-10-09 |
FR2519988B1 (fr) | 1985-06-14 |
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