ES8304955A1 - A process for the preparation of oxadiazolidine derivatives - Google Patents
A process for the preparation of oxadiazolidine derivativesInfo
- Publication number
- ES8304955A1 ES8304955A1 ES509991A ES509991A ES8304955A1 ES 8304955 A1 ES8304955 A1 ES 8304955A1 ES 509991 A ES509991 A ES 509991A ES 509991 A ES509991 A ES 509991A ES 8304955 A1 ES8304955 A1 ES 8304955A1
- Authority
- ES
- Spain
- Prior art keywords
- oxadiazolidine
- derivatives
- reacted
- image
- base
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 2
- DTHHUAXKOMWYBI-UHFFFAOYSA-N oxadiazolidine Chemical class C1CONN1 DTHHUAXKOMWYBI-UHFFFAOYSA-N 0.000 title abstract 2
- 150000003672 ureas Chemical class 0.000 abstract 3
- -1 alkyl chloroformate Chemical compound 0.000 abstract 2
- 239000004202 carbamide Substances 0.000 abstract 2
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
- 150000002443 hydroxylamines Chemical class 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000012948 isocyanate Substances 0.000 abstract 1
- 150000002513 isocyanates Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
- 238000006798 ring closing metathesis reaction Methods 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
- C07D271/07—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
A method for the continuous semi-continuous or batchwise production of oxadiazolidine derivatives having the general formula (I), < IMAGE > wherein R<1> and R<2> represent an aromatic or heteroaromatic group or a straight- chained, branched or cyclic, saturated or unsaturated C1-6 aliphatic hydrocarbyl group wherein a hydroxylamine derivative R'NHOH is first reacted with an isocyanate R<2>NCO in a water-miscible solvent at a pH of between 4 and 7.5 to form a free urea derivative HONR<1>CONHR<2> which is then reacted with an alkyl chloroformate to produce a substituted urea of the formula < IMAGE > in the presence of an aqueous solution of a base. The alkyl chloroformate is introduced either simultaneously or prior to the base such that the pH of the reaction mixture does not exceed 8. Finally the substituted urea is subjected to ring closure by adjusting the pH of the mixture between 9 and 10.5. The intermediates need not be isolated.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU20681 | 1981-01-30 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES509991A0 ES509991A0 (en) | 1983-04-16 |
| ES8304955A1 true ES8304955A1 (en) | 1983-04-16 |
Family
ID=10948475
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES509991A Expired ES8304955A1 (en) | 1981-01-30 | 1982-01-29 | A process for the preparation of oxadiazolidine derivatives |
Country Status (7)
| Country | Link |
|---|---|
| JP (1) | JPS57183765A (en) |
| BR (1) | BR8200516A (en) |
| DD (1) | DD202150A5 (en) |
| ES (1) | ES8304955A1 (en) |
| GB (1) | GB2095660B (en) |
| IT (1) | IT1155457B (en) |
| SU (1) | SU1181542A3 (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0740615B2 (en) * | 1986-04-15 | 1995-05-01 | 日本電気株式会社 | Pulse laser oscillator |
| US5803076A (en) * | 1996-04-15 | 1998-09-08 | Myers; Warren R. | Vacuum adherent face mask |
-
1982
- 1982-01-28 GB GB8202453A patent/GB2095660B/en not_active Expired
- 1982-01-28 IT IT67084/82A patent/IT1155457B/en active
- 1982-01-29 ES ES509991A patent/ES8304955A1/en not_active Expired
- 1982-01-29 SU SU823381946A patent/SU1181542A3/en active
- 1982-01-29 BR BR8200516A patent/BR8200516A/en unknown
- 1982-01-29 JP JP57011902A patent/JPS57183765A/en active Pending
- 1982-02-01 DD DD82237117A patent/DD202150A5/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DD202150A5 (en) | 1983-08-31 |
| IT8267084A0 (en) | 1982-01-28 |
| BR8200516A (en) | 1982-12-07 |
| JPS57183765A (en) | 1982-11-12 |
| ES509991A0 (en) | 1983-04-16 |
| GB2095660A (en) | 1982-10-06 |
| IT1155457B (en) | 1987-01-28 |
| GB2095660B (en) | 1985-02-20 |
| SU1181542A3 (en) | 1985-09-23 |
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