ES8304799A1 - Procedimiento de obtencion de una composicion estable liofilizada para el control del sangrado en hemofilias. - Google Patents

Procedimiento de obtencion de una composicion estable liofilizada para el control del sangrado en hemofilias.

Info

Publication number
ES8304799A1
ES8304799A1 ES513171A ES513171A ES8304799A1 ES 8304799 A1 ES8304799 A1 ES 8304799A1 ES 513171 A ES513171 A ES 513171A ES 513171 A ES513171 A ES 513171A ES 8304799 A1 ES8304799 A1 ES 8304799A1
Authority
ES
Spain
Prior art keywords
factor
activity
vii
coagulation factors
blood coagulation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES513171A
Other languages
English (en)
Other versions
ES513171A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Corp
Original Assignee
Cutter Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22547053&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES8304799(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Cutter Laboratories Inc filed Critical Cutter Laboratories Inc
Publication of ES513171A0 publication Critical patent/ES513171A0/es
Publication of ES8304799A1 publication Critical patent/ES8304799A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/647—Blood coagulation factors not provided for in a preceding group or according to more than one of the proceeding groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
    • A61L2/0017—Filtration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
    • A61L2/022—Filtration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Virology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Developmental Biology & Embryology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Steroid Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE UNA COMPOSICION ESTABLE LIOFILIZADA PARA EL CONTROL DEL SANGRADO EN HEMOFILIAS, QUE CONTIENE FACTORES DE COAGULACION II, VII, IX Y X EN FORMA NO ACTIVADA. COMPRENDE LAS SIGUIENTES ETAPAS: PRIMERA, SE APLICA UNA FRACCION DE PLASMA SANGUINEO QUE CONTIENE FACTORES DE COAGULACION II, VII, IX Y X A UN INTERCAMBIADOR ANIONICO QUE ABSORBE LOS FACTORES DE COAGULACION; SEGUNDA, SE ELUYE SELECTIVAMENTE EL INTERCAMBIADOR ANIONICO CON UNA SOLUCION ACUOSA QUE CONTIENE UNA SAL NO VOLATIL E IONES CITRATO; TERCERA, SE SEPARA EL ELUADO QUE CONTIENE LOS FACTORES DE COAGULACION; CUARTA, SE TRATA EL ELUADO PARA REDUCIR LA CONCENTRACION DE SAL VOLATIL HASTA UN NIVEL FISIOLOGICAMENTE ACEPTABLE; Y POR ULTIMO, SE LIOFILIZA EL ELUADO.
ES513171A 1980-05-27 1982-06-16 Procedimiento de obtencion de una composicion estable liofilizada para el control del sangrado en hemofilias. Expired ES8304799A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US15339680A 1980-05-27 1980-05-27

Publications (2)

Publication Number Publication Date
ES513171A0 ES513171A0 (es) 1983-03-16
ES8304799A1 true ES8304799A1 (es) 1983-03-16

Family

ID=22547053

Family Applications (2)

Application Number Title Priority Date Filing Date
ES502498A Expired ES8300017A1 (es) 1980-05-27 1981-05-26 Procedimiento para preparar un complejo de coagulacion san- guinea
ES513171A Expired ES8304799A1 (es) 1980-05-27 1982-06-16 Procedimiento de obtencion de una composicion estable liofilizada para el control del sangrado en hemofilias.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES502498A Expired ES8300017A1 (es) 1980-05-27 1981-05-26 Procedimiento para preparar un complejo de coagulacion san- guinea

Country Status (6)

Country Link
EP (1) EP0041174B1 (es)
JP (1) JPS5711924A (es)
AT (1) ATE15489T1 (es)
CA (1) CA1170183A (es)
DE (1) DE3172210D1 (es)
ES (2) ES8300017A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT399095B (de) * 1986-03-27 1995-03-27 Vukovich Thomas Dr Verfahren zur auftrennung von proteinen mittels gradientenelution und vorrichtung zur durchführung des verfahrens
ES2045167T5 (es) * 1987-10-23 1996-07-01 Centre Regional De Transfusion Preparacion de concentrado de factor ix humano de elevada pureza y de otras proteinas plasmaticas.
FR2622108B1 (fr) * 1987-10-23 1990-03-02 Lille Transfusion Sanguine Preparation de concentres de proconvertine (facteur vii), de facteur antihemophilique b (facteur ix) et d'autres proteines plasmatiques, et leur utilisation therapeutique
DE3826792C1 (es) * 1988-08-06 1989-07-06 Biotest Pharma Gmbh, 6072 Dreieich, De
DE3914869C1 (es) * 1989-05-05 1990-08-09 Biotest Pharma Gmbh, 6072 Dreieich, De
DE59712322D1 (de) * 1996-03-20 2005-06-30 Baxter Ag Pharmazeutisches Präparat zur Behandlung von Blutgerinnungsstörungen

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE405549B (sv) * 1975-10-09 1978-12-18 Pharmacia Fine Chemicals Ab Forfarande for isolering av albumin ur plasmaprodukter genom kromatografisk fraktionering
AT350726B (de) * 1976-08-30 1979-06-11 Immuno Ag Verfahren zur herstellung einer blut- gerinnungsfoerdernden praeperation aus menschlichem blutplasma
DE2902158A1 (de) * 1979-01-20 1980-07-31 Biotest Serum Institut Gmbh Verfahren zur herstellung von fibrinogen, einem die gerinnungsfaktoren ii, vii, ix und x enthaltenden prothrombinkomplex, antithrombin iii und einer loesung von lagerstabilen serumproteinen

Also Published As

Publication number Publication date
ES513171A0 (es) 1983-03-16
ES502498A0 (es) 1982-10-01
EP0041174A1 (en) 1981-12-09
CA1170183A (en) 1984-07-03
EP0041174B1 (en) 1985-09-11
ATE15489T1 (de) 1985-09-15
JPS5711924A (en) 1982-01-21
DE3172210D1 (en) 1985-10-17
ES8300017A1 (es) 1982-10-01

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