ES8301988A1 - Procedure for obtaining a guanine derivative with antivirastic activity (Machine-translation by Google Translate, not legally binding)
- Google Patents
Procedure for obtaining a guanine derivative with antivirastic activity (Machine-translation by Google Translate, not legally binding)
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Laboratorio Farmaceutico Quimico Lafarquim SA
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Laboratorio Farmaceutico Quimico Lafarquim SA
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Priority to ES506094ApriorityCriticalpatent/ES506094A0/en
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Publication of ES506094A0publicationCriticalpatent/ES506094A0/en
Low-Molecular Organic Synthesis Reactions Using Catalysts
(AREA)
Abstract
Procedure for the obtaining of a guanine derivative with formula activity (I). Reagent guanine and hexametildisilazan or other appropriate silicant agent, such as trimetilsilillo chloride, in an adequate anhydride, such as benzene, dimethylformamide or similar, containing equimolary amounts of a tertiary amine, such as piridine or triethylline to reflux, during a time understood between 2 and 24 hours. Therefore, there is reaction through reaction sodium hydroid and iodometil (trimetilsililoxi) etil eter in dimethylformamide and inert atmosphere, at temperature comprised between -80º and 10ºc and in a time that rocks between 15 minutes and 6 hours. The product is isolated by extraction with chloroform and purified by chromotography in column using as neutral aluminum support and as an eyanol/chloroform mixer. (Machine-translation by Google Translate, not legally binding)
ES506094A1981-10-071981-10-07
PROCEDURE FOR OBTAINING A GUANINA DERIVATIVE WITH ANTIVIRASSIC ACTIVITY
GrantedES506094A0
(en)
A method for the preparation of a 2-methyl-4-hydroxy-2H-1, 2-benzotiacin-1, 1-dioxide-3- (N-2-piridyl) -carboxamide (Machine-translation by Google Translate, not legally binding)
A procedure for the production of 1-b-d-arabinofuranosil-5- (2-carboxivinil) uracil or its derivatives. (Machine-translation by Google Translate, not legally binding)