ES8301987A1 - Cycloalka(4,5)pyrrolo(2,3-g)isoquinoline - Google Patents

Cycloalka(4,5)pyrrolo(2,3-g)isoquinoline

Info

Publication number
ES8301987A1
ES8301987A1 ES509169A ES509169A ES8301987A1 ES 8301987 A1 ES8301987 A1 ES 8301987A1 ES 509169 A ES509169 A ES 509169A ES 509169 A ES509169 A ES 509169A ES 8301987 A1 ES8301987 A1 ES 8301987A1
Authority
ES
Spain
Prior art keywords
compound
isomero
trans
mixture
hydroxyalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES509169A
Other languages
Spanish (es)
Other versions
ES509169A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES8301987A1 publication Critical patent/ES8301987A1/en
Publication of ES509169A0 publication Critical patent/ES509169A0/en
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

A procedure for the preparation of cicloalca/4,5/pirrolo/2,3-g/isoquinolinas. Is to reactively replace a general compound (I) in the atom of isoquinolic nitrogen. Compound (II) is obtained which optionally is subject to the following operations: a) isomerize the mixture to a final relationship that promptly comprises the isomero trans. B) separate the isomero trans of the mixture obtained. C) resolve the racemical mixture obtained in the optical antipodas. D) convert the obtained compound or a non pharmaceutically acceptable addition salt in a salt that is. R is rent, hydroxyalkyl, aryl hydroxyalkyl, alcoxyalkyl, aciloxyalkyl, acilalkyl, alkenyl and others; x is oxygen or sulfur; n es 3, 4, 5 or 6. (Machine-translation by Google Translate, not legally binding)
ES509169A 1980-02-28 1982-01-29 "A PROCEDURE FOR THE PREPARATION OF CICLOALCA 4,5 PIRROLO 2,3-G-ISOQUINOLINAS" AS A DIVISIONAL OF INVENTION PATENT N 499.861 OF FEBRUARY 27, 1981. Granted ES509169A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US12560480A 1980-02-28 1980-02-28

Publications (2)

Publication Number Publication Date
ES8301987A1 true ES8301987A1 (en) 1982-12-16
ES509169A0 ES509169A0 (en) 1982-12-16

Family

ID=22420533

Family Applications (4)

Application Number Title Priority Date Filing Date
ES499861A Granted ES499861A0 (en) 1980-02-28 1981-02-27 A PROCEDURE FOR THE PREPARATION OF CYCLOALCA (4,5) PI- ROLLO (2,3-G) -ISOQUINOLINAS
ES509169A Granted ES509169A0 (en) 1980-02-28 1982-01-29 "A PROCEDURE FOR THE PREPARATION OF CICLOALCA 4,5 PIRROLO 2,3-G-ISOQUINOLINAS" AS A DIVISIONAL OF INVENTION PATENT N 499.861 OF FEBRUARY 27, 1981.
ES509167A Granted ES509167A0 (en) 1980-02-28 1982-01-29 "A PROCEDURE FOR THE PREPARATION OF CICLOALCA 4,5 PIRROLO 2,3-G-ISOQUINOLINAS" AS A DIVISIONAL OF THE INVENTION PATENT N 499.861 OF 02-27-81.
ES509166A Expired ES8301985A1 (en) 1980-02-28 1982-01-29 Cycloalka(4,5)pyrrolo(2,3-g)isoquinoline

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES499861A Granted ES499861A0 (en) 1980-02-28 1981-02-27 A PROCEDURE FOR THE PREPARATION OF CYCLOALCA (4,5) PI- ROLLO (2,3-G) -ISOQUINOLINAS

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES509167A Granted ES509167A0 (en) 1980-02-28 1982-01-29 "A PROCEDURE FOR THE PREPARATION OF CICLOALCA 4,5 PIRROLO 2,3-G-ISOQUINOLINAS" AS A DIVISIONAL OF THE INVENTION PATENT N 499.861 OF 02-27-81.
ES509166A Expired ES8301985A1 (en) 1980-02-28 1982-01-29 Cycloalka(4,5)pyrrolo(2,3-g)isoquinoline

Country Status (5)

Country Link
JP (1) JPS56128780A (en)
KR (4) KR850000029B1 (en)
ES (4) ES499861A0 (en)
GR (1) GR74044B (en)
ZA (1) ZA81921B (en)

Also Published As

Publication number Publication date
KR850000030B1 (en) 1985-02-13
ES509166A0 (en) 1982-12-16
ES8301986A1 (en) 1982-12-16
ES509167A0 (en) 1982-12-16
ES8203892A1 (en) 1982-05-01
KR850000029B1 (en) 1985-02-13
ZA81921B (en) 1982-03-31
KR850000032B1 (en) 1985-02-13
GR74044B (en) 1984-06-06
JPS56128780A (en) 1981-10-08
KR850000031B1 (en) 1985-02-13
ES8301985A1 (en) 1982-12-16
ES509169A0 (en) 1982-12-16
ES499861A0 (en) 1982-05-01
KR830005213A (en) 1983-08-03

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