ES8301468A1 - Procedimiento para la obtencion de 1,4-dihidropiridinas 4,4-disustituidas - Google Patents

Procedimiento para la obtencion de 1,4-dihidropiridinas 4,4-disustituidas

Info

Publication number
ES8301468A1
ES8301468A1 ES503372A ES503372A ES8301468A1 ES 8301468 A1 ES8301468 A1 ES 8301468A1 ES 503372 A ES503372 A ES 503372A ES 503372 A ES503372 A ES 503372A ES 8301468 A1 ES8301468 A1 ES 8301468A1
Authority
ES
Spain
Prior art keywords
phenyl
carbon atoms
radical
optionally
halogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES503372A
Other languages
English (en)
Other versions
ES503372A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Publication of ES503372A0 publication Critical patent/ES503372A0/es
Publication of ES8301468A1 publication Critical patent/ES8301468A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10—Spiro-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
  • Secondary Cells (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE 1,4-DIHIDROPIRIDINAS,4,4- DISUSTITUIDAS, DE FORMULA GENERAL (I), EN DONDE R SIGNIFICA ARILO, FURILO, PIRRIDILO, QUINOLILO O QUENIOSALILO; R Y R SIGNIFICAN HIDROGENO O UN RESTO ALQUILO; R Y R SIGNIFICAN UN RESTO DE HIDROCARBURO; Y R SIGNIFICA UN RESTO DE HIDROCARBURO; ASI COMO SUS SALES DE ADICION DE ACIDO, FARMACEUTICAMENTE ACEPTABLES. CONSISTE EN SOMETER UN COMPUESTO ESPIRO-1,4-DIHIDROPIRIDINAS 4,4DISUSTITUIDAS, DE FORMULA GENERAL (II), DONDE R , R , R , R Y R TIENEN EL SIGNIFICADO YA INDICADO; A SIGNIFICA LO MISMO QUE R; Y W SIGNIFICA 0,1 O 2, A UN PROCESO DE DESULFURACION, EN PRESENCIA DE CATALIZADORES DE METAL PESADO Y A UNA TEMPERATURA COMPRENDIDA ENTRE 0 Y 120 GRADOS. DE APLICACION EN MEDICAMENTOS RELACIONADOS CON LA CIRCULACION SANGUINEA.
ES503372A 1980-06-25 1981-06-25 Procedimiento para la obtencion de 1,4-dihidropiridinas 4,4-disustituidas Expired ES8301468A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19803023821 DE3023821A1 (de) 1980-06-25 1980-06-25 4,4-disubstituierte 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln

Publications (2)

Publication Number Publication Date
ES503372A0 ES503372A0 (es) 1982-12-01
ES8301468A1 true ES8301468A1 (es) 1982-12-01

Family

ID=6105450

Family Applications (1)

Application Number Title Priority Date Filing Date
ES503372A Expired ES8301468A1 (es) 1980-06-25 1981-06-25 Procedimiento para la obtencion de 1,4-dihidropiridinas 4,4-disustituidas

Country Status (5)

Country Link
EP (1) EP0042566B1 (es)
JP (1) JPS5732265A (es)
AT (1) ATE9222T1 (es)
DE (2) DE3023821A1 (es)
ES (1) ES8301468A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60120861A (ja) * 1983-12-02 1985-06-28 Otsuka Pharmaceut Co Ltd ジヒドロピリジン誘導体
US4672068A (en) * 1984-05-04 1987-06-09 Fujirebio Kabushiki Kaisha Antihypertensive 1,4-dihydropyridines having a conjugated ester

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1963186C3 (de) * 1969-12-17 1979-02-15 Bayer Ag, 5090 Leverkusen Schwefelhaltige 1,4-Dihydropyridin-33-dicarbonsäureester
DE2349538C2 (de) * 1973-10-02 1982-08-26 Ordena trudovogo krasnogo znameni institut organičeskogo sinteza Akademii Nauk Latvijskoj SSR, Riga Arzneimittel zur Behandlung von Lebererkrankungen

Also Published As

Publication number Publication date
EP0042566B1 (de) 1984-09-05
JPS5732265A (en) 1982-02-20
ES503372A0 (es) 1982-12-01
DE3165846D1 (en) 1984-10-11
EP0042566A1 (de) 1981-12-30
DE3023821A1 (de) 1982-01-21
ATE9222T1 (de) 1984-09-15

Similar Documents

Publication Publication Date Title
FI875229A (fi) Menetelmä uusien farmakologisesti aktiivisten katekolijohdoksien valmistamiseksi
DK303481A (da) Fremgangsmaade til fremstilling af amider af hydroxyfenyl-alkylaminoaetanoler eller terapeutisk acceptable salte deraf
SE8203887D0 (sv) Nya trombininhiberande foreningar
FR2680507B1 (fr) Nouvelles naphtylethylurees et naphtylethylthiourees, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
OA05386A (fr) Nouvelles N-(3-trifluorométhyl-4-halogéno-phényl)-N'-benzolyl-urées, leur procédé de préparation et leur application comme insecticides.
ES470458A1 (es) Procedimiento para la obtencion de sales de 1-(2-feniletil) triazolio de efecto fungicida
GB1369401A (en) Process for the manufacture of 2-amino-1,4-dihydropyridines and their use as coronary agents
ES2008962A6 (es) Proceso para la preparacion de nuevos compuestos de 2-guanidinotiazol
JPS56103168A (en) Thiazole derivative, its preparation, and antihistaminic agent containing the same
ES8100800A1 (es) Procedimiento para la preparacion de derivados furanonicos
BE847915R (fr) Nouvelles cycloalcano (b) thienylurees substituees utiles notamment comme agents de croissance pour animaux et comme herbicides, et leur procede de preparation
ES8301468A1 (es) Procedimiento para la obtencion de 1,4-dihidropiridinas 4,4-disustituidas
FR2660657B1 (fr) Nouveaux derives du 3-aminochromane, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
GB1465025A (en) Substituted phenylisothioureas a process for their preparation and their use as medicaments
DE3661198D1 (en) Phosphate ester derivatives, and their use as anti-cancer agents
GB1379005A (en) 2,6-diaminodihydropyridines their production and their medicinal use
DE3371201D1 (en) Plant growth regulators
ES450299A1 (es) Un procedimiento de fabricacion de nuevos compuestos quimi- cos derivados de n-pinolidin-2-etilamina.
KR900018029A (ko) 피리딘 유도체 및 이들을 사용하는 살균방법
ES449874A1 (es) Procedimiento para la obtencion de un agente para el trata- miento de la mistitis bovina.
ES486580A1 (es) Un procedimiento para preparar compuestos con propiedades broncodilatadoras
HUT39968A (en) Herbicide compositions containing thiadiazolyl-oxy-acetamide derivatives as active ingredients and process for preparing the active substances
GR3000969T3 (en) Alkyl carboxamides of pyridyl alkyl amines, their preparation and their use as medicaments
EP0171760A3 (en) Substituted phenoxypropylaminoethoxyphenoxyacetamides
GB1173304A (en) A Process for the Manufacture of Benzoxadiaz[4,1,5]Ocines