ES8300771A1 - Un procedimiento para la preparacion de acidos 6-(2-abril-2(1,1-dioxopenicilanoiloximetoxicarbonil)acetamido) penicilanicos. - Google Patents

Un procedimiento para la preparacion de acidos 6-(2-abril-2(1,1-dioxopenicilanoiloximetoxicarbonil)acetamido) penicilanicos.

Info

Publication number
ES8300771A1
ES8300771A1 ES508513A ES508513A ES8300771A1 ES 8300771 A1 ES8300771 A1 ES 8300771A1 ES 508513 A ES508513 A ES 508513A ES 508513 A ES508513 A ES 508513A ES 8300771 A1 ES8300771 A1 ES 8300771A1
Authority
ES
Spain
Prior art keywords
dioxopenicillanoyloxy
acetamido
methoxycarbonyl
aryl
penicillanic acids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES508513A
Other languages
English (en)
Other versions
ES508513A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of ES508513A0 publication Critical patent/ES508513A0/es
Publication of ES8300771A1 publication Critical patent/ES8300771A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE ACIDOS 6-<014>2-ARIL-2-(1,1-DIOXOPENICILANOILOXIMETOXICARBONIL)ACETAMIDO<015> PENICILANICOS DE FORMULA (I), EN LA QUE R ES FENILO O 3-TIENILO; Y R ES UN GRUPO PROTECTOR DEL CARBOXI. CONSISTE EN LA REACCION DE UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA (III), EN LAS QUE R Y R TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I), M ES CATION DE UNA BASE ORGANICA O INORGANICA; Y X ES CLORO, BROMO O YODO. LA REACCION SE LLEVA A CABO EN UN DISOLVENTE ORGANICO INERTE, A UNA TEMPERATURA ENTRE -10<025>C Y 60<025>C. >ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS COMO AGENTES ANTIBACTERIAN
ES508513A 1981-01-05 1982-01-04 Un procedimiento para la preparacion de acidos 6-(2-abril-2(1,1-dioxopenicilanoiloximetoxicarbonil)acetamido) penicilanicos. Expired ES8300771A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/222,239 US4323499A (en) 1981-01-05 1981-01-05 6-(2-Aryl-2-(1,1-dioxopenicillanoyloxy-methoxycarbonyl)acetamido penicillanic acids

Publications (2)

Publication Number Publication Date
ES508513A0 ES508513A0 (es) 1982-11-01
ES8300771A1 true ES8300771A1 (es) 1982-11-01

Family

ID=22831442

Family Applications (1)

Application Number Title Priority Date Filing Date
ES508513A Expired ES8300771A1 (es) 1981-01-05 1982-01-04 Un procedimiento para la preparacion de acidos 6-(2-abril-2(1,1-dioxopenicilanoiloximetoxicarbonil)acetamido) penicilanicos.

Country Status (10)

Country Link
US (1) US4323499A (es)
EP (1) EP0055933B1 (es)
JP (1) JPS57134490A (es)
AR (1) AR227806A1 (es)
AT (1) ATE10499T1 (es)
DE (1) DE3167515D1 (es)
DK (1) DK482A (es)
ES (1) ES8300771A1 (es)
GR (1) GR75133B (es)
IE (1) IE51885B1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4377590A (en) * 1982-05-10 1983-03-22 Pfizer Inc. Derivatives of ampicillin and amoxicillin with beta-lactamase inhibitors
US4428935A (en) 1982-05-24 1984-01-31 Pfizer Inc. Penicillanic acid dioxide prodrug
US4462934A (en) * 1983-03-31 1984-07-31 Pfizer Inc. Bis-esters of dicarboxylic acids with amoxicillin and certain hydroxymethylpenicillanate 1,1-dioxides
US5835182A (en) * 1996-09-16 1998-11-10 Einarsson; Einar Th. Lens-free assembly for shading eyes from incoming light
CN115385934A (zh) * 2022-10-26 2022-11-25 北京纳百生物科技有限公司 一种舒巴坦半抗原及其合成方法和应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3951957A (en) * 1970-03-12 1976-04-20 Lovens Kemiske Fabrik Produktionsaktieselskab Chloromethyl ester of penicillins
US3679801A (en) * 1970-05-19 1972-07-25 Pfizer Aryl esters of {60 -carboxyarylmethyl-penicillins
US3681342A (en) * 1970-11-12 1972-08-01 Pfizer Esters of -carboxybenzylpenicillin
GB1335718A (en) * 1971-05-05 1973-10-31 Leo Pharm Prod Ltd Penicillin esters salts thereof and methods for their preparation
US3838152A (en) * 1971-10-07 1974-09-24 American Home Prod Poly alpha-amino penicillins
FR2205310A1 (en) * 1972-11-08 1974-05-31 Aries Robert Alpha penicillanamido penicillanic acids - long acting antibacterials prepd. by amidation of a mixed anhydride with an alpha amino penicillin
GB1467604A (en) * 1974-06-27 1977-03-16 Toyama Chemical Co Ltd Bis-type penicillins and process for producing the same
US4171303A (en) * 1974-07-30 1979-10-16 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt. Process for the preparation of reactive penicillanic acid and cephalosporanic acid derivatives
GB1579931A (en) * 1976-04-15 1980-11-26 Leo Pharm Prod Ltd Bis-penicillanoyl-oxy-alkanes
US4234579A (en) * 1977-06-07 1980-11-18 Pfizer Inc. Penicillanic acid 1,1-dioxides as β-lactamase inhibitors
US4244951A (en) * 1979-05-16 1981-01-13 Pfizer Inc. Bis-esters of methanediol with penicillins and penicillanic acid 1,1-dioxide

Also Published As

Publication number Publication date
EP0055933A2 (en) 1982-07-14
AR227806A1 (es) 1982-12-15
US4323499A (en) 1982-04-06
ATE10499T1 (de) 1984-12-15
JPS57134490A (en) 1982-08-19
DE3167515D1 (de) 1985-01-10
ES508513A0 (es) 1982-11-01
EP0055933A3 (en) 1982-10-27
IE820004L (en) 1982-07-05
EP0055933B1 (en) 1984-11-28
DK482A (da) 1982-08-20
GR75133B (es) 1984-07-13
IE51885B1 (en) 1987-04-15
JPS6311355B2 (es) 1988-03-14

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