ES8207528A1 - Un procedimiento para la preparacion de nuevos pirazimil-1,2,4- oxadiazoles sustituidos. - Google Patents

Un procedimiento para la preparacion de nuevos pirazimil-1,2,4- oxadiazoles sustituidos.

Info

Publication number
ES8207528A1
ES8207528A1 ES502282A ES502282A ES8207528A1 ES 8207528 A1 ES8207528 A1 ES 8207528A1 ES 502282 A ES502282 A ES 502282A ES 502282 A ES502282 A ES 502282A ES 8207528 A1 ES8207528 A1 ES 8207528A1
Authority
ES
Spain
Prior art keywords
same
oxadiazoles
preparing
processes
pharmaceutical composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES502282A
Other languages
English (en)
Spanish (es)
Other versions
ES502282A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/151,494 external-priority patent/US4309540A/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of ES8207528A1 publication Critical patent/ES8207528A1/es
Publication of ES502282A0 publication Critical patent/ES502282A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
ES502282A 1980-05-19 1981-05-18 Un procedimiento para la preparacion de nuevos pirazimil-1,2,4- oxadiazoles sustituidos. Granted ES502282A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/151,494 US4309540A (en) 1980-05-19 1980-05-19 Substituted pyrazinyl-1,2,4-oxadiazoles
US06/244,509 US4362724A (en) 1980-05-19 1981-03-16 Method of treating edema and hypertension and pharmaceutical composition therefor in which the active ingredient comprises a novel substituted pyrazinyl-1,2,4-oxadiazole and a kaliuretic diuretic

Publications (2)

Publication Number Publication Date
ES8207528A1 true ES8207528A1 (es) 1982-10-01
ES502282A0 ES502282A0 (es) 1982-10-01

Family

ID=26848697

Family Applications (1)

Application Number Title Priority Date Filing Date
ES502282A Granted ES502282A0 (es) 1980-05-19 1981-05-18 Un procedimiento para la preparacion de nuevos pirazimil-1,2,4- oxadiazoles sustituidos.

Country Status (12)

Country Link
US (1) US4362724A (enExample)
EP (1) EP0040422B1 (enExample)
AU (1) AU536493B2 (enExample)
DE (1) DE3161767D1 (enExample)
DK (1) DK214681A (enExample)
ES (1) ES502282A0 (enExample)
FI (1) FI811421L (enExample)
GR (1) GR74903B (enExample)
IE (1) IE51288B1 (enExample)
NO (1) NO811667L (enExample)
NZ (1) NZ197055A (enExample)
PT (1) PT73016B (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6858615B2 (en) 2002-02-19 2005-02-22 Parion Sciences, Inc. Phenyl guanidine sodium channel blockers
US6858614B2 (en) * 2002-02-19 2005-02-22 Parion Sciences, Inc. Phenolic guanidine sodium channel blockers
US6903105B2 (en) 2003-02-19 2005-06-07 Parion Sciences, Inc. Sodium channel blockers
US7745442B2 (en) 2003-08-20 2010-06-29 Parion Sciences, Inc. Methods of reducing risk of infection from pathogens
AR086745A1 (es) 2011-06-27 2014-01-22 Parion Sciences Inc 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida
CN108658876A (zh) 2012-12-17 2018-10-16 帕里昂科学公司 3,5-二氨基-6-氯-n-(n-(4-苯基丁基)甲脒基)吡嗪-2-甲酰胺化合物
HUE032891T2 (hu) 2012-12-17 2017-11-28 Parion Sciences Inc Klórpirazin-karboxamid-származékok nem kielégítõ nyálkahártya-hidratáció által elõsegített megbetegedések kezelésére
US9102633B2 (en) 2013-12-13 2015-08-11 Parion Sciences, Inc. Arylalkyl- and aryloxyalkyl-substituted epithelial sodium channel blocking compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL299931A (enExample) * 1962-10-30
MC641A1 (fr) * 1967-03-08 1967-12-05 Mauvernay Roland Yves Nouveaux composés chimiques et procédé pour leur préparation
US4196292A (en) * 1977-06-29 1980-04-01 Merck & Co., Inc. 6-Substituted amiloride derivatives
EP0009054A1 (en) * 1978-09-19 1980-04-02 Merck & Co. Inc. N-Pyrazinecarbonyl-N'-substituted-sulfamoyl-guanidine and processes for preparing same

Also Published As

Publication number Publication date
DK214681A (da) 1981-11-20
AU7018081A (en) 1981-11-26
FI811421A7 (fi) 1981-11-20
EP0040422B1 (en) 1983-12-28
US4362724A (en) 1982-12-07
NZ197055A (en) 1984-07-31
IE51288B1 (en) 1986-11-26
FI811421L (fi) 1981-11-20
AU536493B2 (en) 1984-05-10
PT73016A (en) 1981-06-01
DE3161767D1 (en) 1984-02-02
PT73016B (en) 1983-08-08
ES502282A0 (es) 1982-10-01
EP0040422A1 (en) 1981-11-25
NO811667L (no) 1981-11-20
GR74903B (enExample) 1984-07-12
IE811102L (en) 1981-11-19

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