ES8206501A1 - 2-Guanidinothiazoles - Google Patents

2-Guanidinothiazoles

Info

Publication number
ES8206501A1
ES8206501A1 ES501736A ES501736A ES8206501A1 ES 8206501 A1 ES8206501 A1 ES 8206501A1 ES 501736 A ES501736 A ES 501736A ES 501736 A ES501736 A ES 501736A ES 8206501 A1 ES8206501 A1 ES 8206501A1
Authority
ES
Spain
Prior art keywords
optionally substituted
alkyl
cyano
alkoxy
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES501736A
Other languages
Spanish (es)
Other versions
ES501736A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Publication of ES501736A0 publication Critical patent/ES501736A0/en
Publication of ES8206501A1 publication Critical patent/ES8206501A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/48—Acylated amino or imino radicals by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof, e.g. carbonylguanidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Compounds of the general formula: < IMAGE > (wherein n is an integer from 2 to 4 R is hydrogen, C1-C6 alkyl (optionally substituted by hydroxy, cyano, amino or phenoxy), C3-C6 cycloalkyl, C2-C6 alkenyl (optionally substituted by phenyl or C2-C7 alkoxy-carbonyl), C4-C7 alkadienyl, C6-C12 aryl (optionally substituted by one to three groups selected from halogen, cyano, nitro, amino, C2-C10 dialkylamino, tetrazolyl, hydroxy, C1-C6 alkoxy, benzoyloxy, C2-C7 alkoxycarbonyl, sulfamoyl, C1-C6 alkylsulfonyl, C1-C6 alkanesulfonamido or C1-C6 alkanoyl), or a heterocycle (optionally substituted by halogen, C1-C6 alkyl or phenyl) and X is a single bond or thia), their 5-halo and alkyl derivatives and salts thereof are anti-peptic ulcer agents and histamine H2 receptor antagonists. The preparation of 1-chloro-3-[2- acetamidoethylthio)-2-propanone is described.
ES501736A 1980-04-29 1981-04-28 2-Guanidinothiazoles Expired ES8206501A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US14494680A 1980-04-29 1980-04-29

Publications (2)

Publication Number Publication Date
ES501736A0 ES501736A0 (en) 1982-08-16
ES8206501A1 true ES8206501A1 (en) 1982-08-16

Family

ID=22510873

Family Applications (1)

Application Number Title Priority Date Filing Date
ES501736A Expired ES8206501A1 (en) 1980-04-29 1981-04-28 2-Guanidinothiazoles

Country Status (16)

Country Link
JP (1) JPS574977A (en)
AR (1) AR231538A1 (en)
AU (1) AU540239B2 (en)
BE (1) BE888602A (en)
CH (1) CH646964A5 (en)
DE (1) DE3116890A1 (en)
DK (1) DK188881A (en)
ES (1) ES8206501A1 (en)
FR (1) FR2481280A1 (en)
GB (1) GB2076397B (en)
IE (1) IE51151B1 (en)
IL (1) IL62747A (en)
IT (1) IT1146750B (en)
NL (1) NL8102099A (en)
NZ (1) NZ196923A (en)
SE (1) SE452462B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2531705B1 (en) * 1982-08-13 1986-12-05 Sanofi Sa AMIDOBENZAMIDES, THEIR SALTS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
US4501747A (en) * 1982-05-10 1985-02-26 Sanofi Certain amide derivatives of 2-guanidino-thiazoles and compositions containing same
JPS59104370A (en) * 1982-12-03 1984-06-16 Kotobuki Seiyaku Kk Thiazole derivative and its production
GB2138803B (en) * 1983-04-26 1986-06-18 Shionogi & Co 2-guanidino-4-hydroxymethylthiazole and derivatives thereof
US4680300A (en) * 1985-01-10 1987-07-14 Syntex (U.S.A.) Inc. Anti-inflammatory guanidines
US4837316A (en) * 1985-08-29 1989-06-06 Fujirebio Kabushiki Kaisha Alkylamide derivatives with H2 -receptor antagonistic and cytoprotective action
EP0385525B1 (en) * 1989-03-03 1994-04-13 Akzo Nv Aminoethylthiazole and aminoethyloxazole derivatives.

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4165378A (en) * 1977-04-20 1979-08-21 Ici Americas Inc. Guanidine derivatives of imidazoles and thiazoles
NO781300L (en) * 1977-04-20 1978-10-23 Ici Ltd PROCEDURE FOR PREPARATION OF PHYSIOLOGICALLY ACTIVE GUANIDINE DERIVATIVES
EP0003640B1 (en) * 1978-01-18 1982-01-27 Imperial Chemical Industries Plc Antisecretory guanidine derivatives, processes for their manufacture and pharmaceutical compositions containing them
DE2966646D1 (en) * 1978-10-16 1984-03-15 Ici Plc Antisecretory branched-chain heterocyclic guanidine derivatives, processes for their manufacture, intermediates, and pharmaceutical compositions containing said derivatives
US4309435A (en) * 1978-10-16 1982-01-05 Imperial Chemical Industries Ltd. Antisecretory guanidine derivatives and pharmaceutical compositions containing them
EP0014057B1 (en) * 1979-01-18 1985-01-02 Imperial Chemical Industries Plc Guanidine derivatives, processes for their manufacture and pharmaceutical compositions containing them
PH16099A (en) * 1979-03-06 1983-06-24 Yamanouchi Pharma Co Ltd Guanidinothiazole compounds,process for preparing them and medical composition containing them
GR71929B (en) * 1979-11-13 1983-08-19 Ici Ltd
JPS5754177A (en) * 1980-09-19 1982-03-31 Teikoku Hormone Mfg Co Ltd Substituted thiazole derivative
JPS57102852A (en) * 1980-12-19 1982-06-26 Shionogi & Co Ltd Dicarboxylic acid diamide

Also Published As

Publication number Publication date
IT1146750B (en) 1986-11-19
JPS574977A (en) 1982-01-11
BE888602A (en) 1981-10-28
GB2076397B (en) 1984-02-08
AR231538A1 (en) 1984-12-28
GB2076397A (en) 1981-12-02
SE8102683L (en) 1981-10-30
DK188881A (en) 1981-10-30
AU540239B2 (en) 1984-11-08
NZ196923A (en) 1983-12-16
JPH027952B2 (en) 1990-02-21
ES501736A0 (en) 1982-08-16
IE51151B1 (en) 1986-10-15
AU6996681A (en) 1981-11-05
NL8102099A (en) 1981-11-16
SE452462B (en) 1987-11-30
IL62747A (en) 1984-10-31
CH646964A5 (en) 1984-12-28
FR2481280A1 (en) 1981-10-30
IE810956L (en) 1981-10-29
IT8167585A0 (en) 1981-04-29
DE3116890A1 (en) 1982-03-04
IL62747A0 (en) 1981-06-29
FR2481280B1 (en) 1983-10-28

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