ES8206501A1 - 2-Guanidinothiazoles - Google Patents
2-GuanidinothiazolesInfo
- Publication number
- ES8206501A1 ES8206501A1 ES501736A ES501736A ES8206501A1 ES 8206501 A1 ES8206501 A1 ES 8206501A1 ES 501736 A ES501736 A ES 501736A ES 501736 A ES501736 A ES 501736A ES 8206501 A1 ES8206501 A1 ES 8206501A1
- Authority
- ES
- Spain
- Prior art keywords
- optionally substituted
- alkyl
- cyano
- alkoxy
- hydroxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/48—Acylated amino or imino radicals by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof, e.g. carbonylguanidines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Compounds of the general formula: < IMAGE > (wherein n is an integer from 2 to 4 R is hydrogen, C1-C6 alkyl (optionally substituted by hydroxy, cyano, amino or phenoxy), C3-C6 cycloalkyl, C2-C6 alkenyl (optionally substituted by phenyl or C2-C7 alkoxy-carbonyl), C4-C7 alkadienyl, C6-C12 aryl (optionally substituted by one to three groups selected from halogen, cyano, nitro, amino, C2-C10 dialkylamino, tetrazolyl, hydroxy, C1-C6 alkoxy, benzoyloxy, C2-C7 alkoxycarbonyl, sulfamoyl, C1-C6 alkylsulfonyl, C1-C6 alkanesulfonamido or C1-C6 alkanoyl), or a heterocycle (optionally substituted by halogen, C1-C6 alkyl or phenyl) and X is a single bond or thia), their 5-halo and alkyl derivatives and salts thereof are anti-peptic ulcer agents and histamine H2 receptor antagonists. The preparation of 1-chloro-3-[2- acetamidoethylthio)-2-propanone is described.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14494680A | 1980-04-29 | 1980-04-29 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8206501A1 true ES8206501A1 (en) | 1982-08-16 |
| ES501736A0 ES501736A0 (en) | 1982-08-16 |
Family
ID=22510873
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES501736A Granted ES501736A0 (en) | 1980-04-29 | 1981-04-28 | PROCEDURE FOR THE PREPARATION OF DERIVATIVES OF 2-GUANIDI-NOTIAZOL |
Country Status (16)
| Country | Link |
|---|---|
| JP (1) | JPS574977A (en) |
| AR (1) | AR231538A1 (en) |
| AU (1) | AU540239B2 (en) |
| BE (1) | BE888602A (en) |
| CH (1) | CH646964A5 (en) |
| DE (1) | DE3116890A1 (en) |
| DK (1) | DK188881A (en) |
| ES (1) | ES501736A0 (en) |
| FR (1) | FR2481280A1 (en) |
| GB (1) | GB2076397B (en) |
| IE (1) | IE51151B1 (en) |
| IL (1) | IL62747A (en) |
| IT (1) | IT1146750B (en) |
| NL (1) | NL8102099A (en) |
| NZ (1) | NZ196923A (en) |
| SE (1) | SE452462B (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4501747A (en) * | 1982-05-10 | 1985-02-26 | Sanofi | Certain amide derivatives of 2-guanidino-thiazoles and compositions containing same |
| FR2531705B1 (en) * | 1982-08-13 | 1986-12-05 | Sanofi Sa | AMIDOBENZAMIDES, THEIR SALTS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
| JPS59104370A (en) * | 1982-12-03 | 1984-06-16 | Kotobuki Seiyaku Kk | Thiazole derivative and its production |
| EP0123741A1 (en) * | 1983-04-26 | 1984-11-07 | Shionogi & Co., Ltd. | 2-Guanidino-4-hydroxymethylthiazole and derivatives thereof |
| US4680300A (en) * | 1985-01-10 | 1987-07-14 | Syntex (U.S.A.) Inc. | Anti-inflammatory guanidines |
| US4837316A (en) * | 1985-08-29 | 1989-06-06 | Fujirebio Kabushiki Kaisha | Alkylamide derivatives with H2 -receptor antagonistic and cytoprotective action |
| EP0385525B1 (en) * | 1989-03-03 | 1994-04-13 | Akzo Nv | Aminoethylthiazole and aminoethyloxazole derivatives. |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4165378A (en) * | 1977-04-20 | 1979-08-21 | Ici Americas Inc. | Guanidine derivatives of imidazoles and thiazoles |
| NO781300L (en) * | 1977-04-20 | 1978-10-23 | Ici Ltd | PROCEDURE FOR PREPARATION OF PHYSIOLOGICALLY ACTIVE GUANIDINE DERIVATIVES |
| DE2961923D1 (en) * | 1978-01-18 | 1982-03-11 | Ici Plc | Antisecretory guanidine derivatives, processes for their manufacture and pharmaceutical compositions containing them |
| CA1140925A (en) | 1978-10-16 | 1983-02-08 | Derrick F. Jones | Antisecretory branched chain heterocyclic derivatives, processes for their manufacture and pharmaceutical compositions containing them |
| US4309435A (en) * | 1978-10-16 | 1982-01-05 | Imperial Chemical Industries Ltd. | Antisecretory guanidine derivatives and pharmaceutical compositions containing them |
| DE3069889D1 (en) * | 1979-01-18 | 1985-02-14 | Ici Plc | Guanidine derivatives, processes for their manufacture and pharmaceutical compositions containing them |
| PH16099A (en) * | 1979-03-06 | 1983-06-24 | Yamanouchi Pharma Co Ltd | Guanidinothiazole compounds,process for preparing them and medical composition containing them |
| GR71929B (en) * | 1979-11-13 | 1983-08-19 | Ici Ltd | |
| JPS5754177A (en) * | 1980-09-19 | 1982-03-31 | Teikoku Hormone Mfg Co Ltd | Substituted thiazole derivative |
| JPS57102852A (en) * | 1980-12-19 | 1982-06-26 | Shionogi & Co Ltd | Dicarboxylic acid diamide |
-
1981
- 1981-04-24 NZ NZ196923A patent/NZ196923A/en unknown
- 1981-04-28 FR FR8108468A patent/FR2481280A1/en active Granted
- 1981-04-28 SE SE8102683A patent/SE452462B/en not_active IP Right Cessation
- 1981-04-28 JP JP6473981A patent/JPS574977A/en active Granted
- 1981-04-28 DK DK188881A patent/DK188881A/en not_active Application Discontinuation
- 1981-04-28 DE DE19813116890 patent/DE3116890A1/en not_active Ceased
- 1981-04-28 BE BE0/204631A patent/BE888602A/en not_active IP Right Cessation
- 1981-04-28 ES ES501736A patent/ES501736A0/en active Granted
- 1981-04-28 NL NL8102099A patent/NL8102099A/en not_active Application Discontinuation
- 1981-04-29 IL IL62747A patent/IL62747A/en unknown
- 1981-04-29 AU AU69966/81A patent/AU540239B2/en not_active Ceased
- 1981-04-29 IE IE956/81A patent/IE51151B1/en unknown
- 1981-04-29 IT IT67585/81A patent/IT1146750B/en active
- 1981-04-29 GB GB8113289A patent/GB2076397B/en not_active Expired
- 1981-04-29 CH CH279381A patent/CH646964A5/en not_active IP Right Cessation
-
1984
- 1984-01-01 AR AR23153884D patent/AR231538A1/en active
Also Published As
| Publication number | Publication date |
|---|---|
| NL8102099A (en) | 1981-11-16 |
| IL62747A (en) | 1984-10-31 |
| FR2481280A1 (en) | 1981-10-30 |
| JPS574977A (en) | 1982-01-11 |
| BE888602A (en) | 1981-10-28 |
| IL62747A0 (en) | 1981-06-29 |
| SE8102683L (en) | 1981-10-30 |
| DE3116890A1 (en) | 1982-03-04 |
| DK188881A (en) | 1981-10-30 |
| AR231538A1 (en) | 1984-12-28 |
| IE51151B1 (en) | 1986-10-15 |
| IT1146750B (en) | 1986-11-19 |
| GB2076397B (en) | 1984-02-08 |
| AU540239B2 (en) | 1984-11-08 |
| JPH027952B2 (en) | 1990-02-21 |
| GB2076397A (en) | 1981-12-02 |
| FR2481280B1 (en) | 1983-10-28 |
| SE452462B (en) | 1987-11-30 |
| IT8167585A0 (en) | 1981-04-29 |
| AU6996681A (en) | 1981-11-05 |
| CH646964A5 (en) | 1984-12-28 |
| IE810956L (en) | 1981-10-29 |
| NZ196923A (en) | 1983-12-16 |
| ES501736A0 (en) | 1982-08-16 |
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