ES8202013A1 - Un procedimiento para la preparacion de nuevos derivados delacido clavulanico. - Google Patents

Un procedimiento para la preparacion de nuevos derivados delacido clavulanico.

Info

Publication number
ES8202013A1
ES8202013A1 ES496266A ES496266A ES8202013A1 ES 8202013 A1 ES8202013 A1 ES 8202013A1 ES 496266 A ES496266 A ES 496266A ES 496266 A ES496266 A ES 496266A ES 8202013 A1 ES8202013 A1 ES 8202013A1
Authority
ES
Spain
Prior art keywords
alkyl
hydrogen
preparation
group
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES496266A
Other languages
English (en)
Other versions
ES496266A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10508806&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES8202013(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of ES496266A0 publication Critical patent/ES496266A0/es
Publication of ES8202013A1 publication Critical patent/ES8202013A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE ACIDO CLAVULANICO, ASI COMO DE SUS SALES Y ESTERES FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE R1 Y R2 SON HIDROGENO O ALQUILO C1-6, Y A ES OXIGENO, AZUFRE O EL GRUPO NR3, DONDE R3 PUEDE SER UNO O VARIOS TIPOS DE RADICALES. CONSISTE EN LA REACCION DE CONDENSACION DE UN COMPUESTO DE FORMULA (II), EN LA QUE R1, R2 Y A TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I), CON UN COMPUESTO DE FORMULA (III), EN LA QUE B PUEDE SER UNO DE VARIOS TIPOS DE RADICALES, O CON UN ESTER O UNA SAL DE MISMO. LA REACCION SE LLEVA A CABO EN UN DISOLVENTE APROTICO, A UNA TEMPERATURA ENTRE -50 50 C. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS COMO AGENTES ANTIBACTERIANOS Y COMO INHIBIDORES DE B-LACTAMASA.
ES496266A 1979-10-26 1980-10-24 Un procedimiento para la preparacion de nuevos derivados delacido clavulanico. Expired ES8202013A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7937261 1979-10-26

Publications (2)

Publication Number Publication Date
ES496266A0 ES496266A0 (es) 1982-01-16
ES8202013A1 true ES8202013A1 (es) 1982-01-16

Family

ID=10508806

Family Applications (1)

Application Number Title Priority Date Filing Date
ES496266A Expired ES8202013A1 (es) 1979-10-26 1980-10-24 Un procedimiento para la preparacion de nuevos derivados delacido clavulanico.

Country Status (8)

Country Link
EP (1) EP0028083B1 (es)
JP (1) JPS5677283A (es)
AU (1) AU6368480A (es)
CA (1) CA1132548A (es)
DE (1) DE3066511D1 (es)
DK (1) DK452880A (es)
ES (1) ES8202013A1 (es)
ZA (1) ZA806375B (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9120808B2 (en) 2009-09-15 2015-09-01 Nabriva Therapeutics Ag Substituted clavulanic acid

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU503489B2 (en) * 1975-10-13 1979-09-06 Beecham Group Limited Substituted aminodeoxy clavulanic acid
GB1585124A (en) * 1976-06-04 1981-02-25 Glaxo Lab Ltd Clavulanic acid derivatives
GB2007667B (en) * 1977-10-28 1982-05-12 Beecham Group Ltd Process for the preparation of ss-lactam compounds
DE2966349D1 (en) * 1978-09-09 1983-12-01 Beecham Group Plc Derivatives of clavulanic acid, a process for their preparation and their use

Also Published As

Publication number Publication date
ZA806375B (en) 1981-10-28
ES496266A0 (es) 1982-01-16
DK452880A (da) 1981-04-27
EP0028083B1 (en) 1984-02-08
CA1132548A (en) 1982-09-28
AU6368480A (en) 1981-04-30
JPS5677283A (en) 1981-06-25
DE3066511D1 (en) 1984-03-15
EP0028083A1 (en) 1981-05-06

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