ES8201567A1 - Epoxysuccinic Acid Derivatives - Google Patents
Epoxysuccinic Acid DerivativesInfo
- Publication number
- ES8201567A1 ES8201567A1 ES498734A ES498734A ES8201567A1 ES 8201567 A1 ES8201567 A1 ES 8201567A1 ES 498734 A ES498734 A ES 498734A ES 498734 A ES498734 A ES 498734A ES 8201567 A1 ES8201567 A1 ES 8201567A1
- Authority
- ES
- Spain
- Prior art keywords
- epoxysuccinic acid
- acid derivatives
- derivatives
- trans
- lower alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- DCEMCPAKSGRHCN-UHFFFAOYSA-N oxirane-2,3-dicarboxylic acid Chemical class OC(=O)C1OC1C(O)=O DCEMCPAKSGRHCN-UHFFFAOYSA-N 0.000 title abstract 3
- 231100000252 nontoxic Toxicity 0.000 abstract 2
- 230000003000 nontoxic effect Effects 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- DCEMCPAKSGRHCN-JCYAYHJZSA-N trans-2,3-epoxysuccinic acid Chemical compound OC(=O)[C@@H]1O[C@H]1C(O)=O DCEMCPAKSGRHCN-JCYAYHJZSA-N 0.000 abstract 2
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 abstract 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 abstract 1
- 125000005907 alkyl ester group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 208000010125 myocardial infarction Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/48—Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Abstract
Novel epoxysuccinic acid derivatives are provided of the formula:- < IMAGE > and non-toxic salts thereof, where R represents a lower alkyl group. These epoxysuccinic acid derivatives and their non-toxic salt are useful for inhibiting myocardial infarction. The derivatives may be made by reacting a leucine lower alkyl ester with a trans- epoxysuccinic acid mono-ester, or trans-epoxysuccinic acid itself.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP690780A JPS56104816A (en) | 1980-01-25 | 1980-01-25 | Preventive and remedy for caridac infarction |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES498734A0 ES498734A0 (en) | 1982-01-01 |
| ES8201567A1 true ES8201567A1 (en) | 1982-01-01 |
Family
ID=11651300
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES498734A Expired ES8201567A1 (en) | 1980-01-25 | 1981-01-22 | Epoxysuccinic Acid Derivatives |
Country Status (7)
| Country | Link |
|---|---|
| JP (1) | JPS56104816A (en) |
| BR (1) | BR8100350A (en) |
| DE (1) | DE3102486A1 (en) |
| ES (1) | ES8201567A1 (en) |
| FR (1) | FR2474497A1 (en) |
| GB (1) | GB2067999A (en) |
| IT (1) | IT1141956B (en) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1595168A (en) * | 1977-03-03 | 1981-08-12 | Taisho Pharmaceutical Co Ltd | Expoxysuccinic acid derivatives |
-
1980
- 1980-01-25 JP JP690780A patent/JPS56104816A/en active Granted
-
1981
- 1981-01-22 ES ES498734A patent/ES8201567A1/en not_active Expired
- 1981-01-23 BR BR8100350A patent/BR8100350A/en unknown
- 1981-01-23 FR FR8101330A patent/FR2474497A1/en active Pending
- 1981-01-26 IT IT19331/81A patent/IT1141956B/en active
- 1981-01-26 DE DE19813102486 patent/DE3102486A1/en not_active Withdrawn
- 1981-01-26 GB GB8102291A patent/GB2067999A/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| ES498734A0 (en) | 1982-01-01 |
| GB2067999A (en) | 1981-08-05 |
| FR2474497A1 (en) | 1981-07-31 |
| IT8119331A0 (en) | 1981-01-26 |
| DE3102486A1 (en) | 1981-11-19 |
| JPS56104816A (en) | 1981-08-20 |
| BR8100350A (en) | 1981-08-11 |
| IT1141956B (en) | 1986-10-08 |
| JPS6365644B2 (en) | 1988-12-16 |
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