ES8105748A1 - Procedimiento para preparar derivados de pirimidina - Google Patents

Procedimiento para preparar derivados de pirimidina

Info

Publication number
ES8105748A1
ES8105748A1 ES492394A ES492394A ES8105748A1 ES 8105748 A1 ES8105748 A1 ES 8105748A1 ES 492394 A ES492394 A ES 492394A ES 492394 A ES492394 A ES 492394A ES 8105748 A1 ES8105748 A1 ES 8105748A1
Authority
ES
Spain
Prior art keywords
processes
pharmaceutical formulations
ribofuranosylpyrazolo
pyrimidines
beta
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES492394A
Other languages
English (en)
Other versions
ES492394A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Publication of ES8105748A1 publication Critical patent/ES8105748A1/es
Publication of ES492394A0 publication Critical patent/ES492394A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE PIRIMIDINA DE FORMULA (I) O DE SUS SALES, EN LA QUE R, R1, R2 Y R3 PUEDEN SER VARIOS TIPOS DE RADICALES Y "N" VALE DE 1 A 6. SE BASA EN LA REACCION ENTRE UNA 1-BETA-D-RIBOFURANOSILPIRALAZO-[3,4-D]-PIRIMIDINA SUSTITUIDA EN POSICION 4 Y UN COMPUESTO DE FORMULA R(CH2)NX, EN DONDE R Y "N" TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I) Y X PUEDE SER UN ATOMO DE HALOGENO, EN CUYO CASO LA REACCION SE EFECTUA EN PRESENCIA DE UNA BASE ORGANICA, INORGANICA O RESINICA, EN UN DISOLVENTE ACUOSO, ALCOHOLICO O APROTIDO, O BIEN UN RADICAL MERCAPTIDA ADECUADO, Y LA REACCION SE EFECTUA EN PRESENCIA DE UN DISOLVENTE APROTIDO. EN EL PRIMER CASO, EL SUSTITUYENTE EN POSICION 4 ES UN RADICAL TIO Y EN EL SEGUNDO UN ATOMO DE HALOGENO O UN RADICAL ALCOHILTIO O ARALCOHILTIO. ESTOS COMPUESTOS SE UTILIZAN COMO AGENTES ANTIPROTOZOARIOS, EN ESPECIAL PARA TRATAR O EVITAR INFECCIONES POR COCCIDIOS. *FORMULA* E
ES492394A 1979-06-14 1980-06-13 Procedimiento para preparar derivados de pirimidina Granted ES492394A0 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB7920700 1979-06-14
GB7920698 1979-06-14
GB7920699 1979-06-14

Publications (2)

Publication Number Publication Date
ES8105748A1 true ES8105748A1 (es) 1981-06-01
ES492394A0 ES492394A0 (es) 1981-06-01

Family

ID=27260724

Family Applications (1)

Application Number Title Priority Date Filing Date
ES492394A Granted ES492394A0 (es) 1979-06-14 1980-06-13 Procedimiento para preparar derivados de pirimidina

Country Status (12)

Country Link
EP (1) EP0021293B1 (es)
AR (1) AR229087A1 (es)
AT (1) AT371482B (es)
AU (1) AU534542B2 (es)
CA (1) CA1147681A (es)
DE (1) DE3064751D1 (es)
DK (1) DK254980A (es)
ES (1) ES492394A0 (es)
IL (1) IL60308A (es)
IT (1) IT1146941B (es)
PH (1) PH16552A (es)
PT (1) PT71393B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990003370A1 (en) * 1988-09-28 1990-04-05 Microprobe Corporation DERIVATIVES OF PYRAZOLO[3,4-d]PYRIMIDINE
US5824796A (en) * 1988-09-28 1998-10-20 Epoch Pharmaceuticals, Inc. Cross-linking oligonucleotides
USRE38416E1 (en) 1988-09-28 2004-02-03 Epoch Biosciences, Inc. Cross-linking oligonucleotides
US5849482A (en) * 1988-09-28 1998-12-15 Epoch Pharmaceuticals, Inc. Crosslinking oligonucleotides
US6136601A (en) * 1991-08-21 2000-10-24 Epoch Pharmaceuticals, Inc. Targeted mutagenesis in living cells using modified oligonucleotides
US5594121A (en) * 1991-11-07 1997-01-14 Gilead Sciences, Inc. Enhanced triple-helix and double-helix formation with oligomers containing modified purines
EP0695306A1 (en) * 1993-04-19 1996-02-07 Gilead Sciences, Inc. Enhanced triple-helix and double-helix formation with oligomers containing modified purines

Also Published As

Publication number Publication date
AU534542B2 (en) 1984-02-02
IL60308A0 (en) 1980-09-16
IT8048967A0 (it) 1980-06-13
AT371482B (de) 1983-06-27
ATA313780A (de) 1982-11-15
CA1147681A (en) 1983-06-07
DE3064751D1 (en) 1983-10-13
EP0021293A2 (en) 1981-01-07
EP0021293A3 (en) 1981-04-01
IT1146941B (it) 1986-11-19
PT71393A (en) 1980-07-01
ES492394A0 (es) 1981-06-01
EP0021293B1 (en) 1983-09-07
PH16552A (en) 1983-11-16
IL60308A (en) 1984-02-29
DK254980A (da) 1980-12-15
AR229087A1 (es) 1983-06-15
AU5927680A (en) 1980-12-18
PT71393B (en) 1981-10-22

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