ES8103028A1 - Procedimiento para la obtencion de nuevos peptidos del tipo somatostatina - Google Patents
Procedimiento para la obtencion de nuevos peptidos del tipo somatostatinaInfo
- Publication number
- ES8103028A1 ES8103028A1 ES489565A ES489565A ES8103028A1 ES 8103028 A1 ES8103028 A1 ES 8103028A1 ES 489565 A ES489565 A ES 489565A ES 489565 A ES489565 A ES 489565A ES 8103028 A1 ES8103028 A1 ES 8103028A1
- Authority
- ES
- Spain
- Prior art keywords
- preparation
- somatostatin
- radical
- trp
- pharmaceutical compositions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
- C07K14/6555—Somatostatins at least 1 amino acid in D-form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
- C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
- C07K1/065—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for hydroxy functions, not being part of carboxy functions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/16—Somatostatin; related peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Endocrinology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Analytical Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE NUEVOS PEPTIDOS DEL TIPO SOMATOSTATINA DE FORMULA GENERAL: *FORMULA* DONDE BMP SIGNIFICA EL RESTO DESAMINOCISTEINA, X SIGNIFICA ASN O HIS; TRP SIGNIFICA D-TRP, QUE PUEDE ESTAR SUSTITUIDO EN EL ANILLO BENCENICO POR UN ATOMO DE HALOGENO E Y SIGNIFICA EL RESTO DE UN ALFA-AMINOACIDO SECUNDARIO CON UN MAXIMO DE 8 ATOMOS DE CARBONO DE LAS CORRESPONDIENTES PEPTIDAMIDAS, ASI COMO DE LAS SALES DE ADICION DE ACIDO Y COMPLEJOS DE ESTOS COMPUESTOS. EL COMPUESTO DESEADO SE OBTIENE POR DISOCIACION DEL COMPUESTO DE FORMULA: BMP(C)-LYS(A)-X-PHE-PHE-TRP-LYS(A'')-THR(B'')-PHE-THR(B'')-Y-CYS(C'')-D DONDE A,A'',B,B'',C,C'' Y D SON DISTINTOS GRUPOS PROTECTORES. Q
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH250679 | 1979-03-16 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES489565A0 ES489565A0 (es) | 1981-02-16 |
ES8103028A1 true ES8103028A1 (es) | 1981-02-16 |
Family
ID=4235326
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES489565A Expired ES8103028A1 (es) | 1979-03-16 | 1980-03-14 | Procedimiento para la obtencion de nuevos peptidos del tipo somatostatina |
Country Status (17)
Country | Link |
---|---|
US (1) | US4316890A (es) |
EP (1) | EP0017760B1 (es) |
JP (1) | JPS55124748A (es) |
KR (1) | KR830001872A (es) |
AT (1) | ATE3283T1 (es) |
AU (1) | AU5646280A (es) |
CA (1) | CA1140117A (es) |
DD (1) | DD151059A5 (es) |
DE (1) | DE3063028D1 (es) |
ES (1) | ES8103028A1 (es) |
FI (1) | FI800795A (es) |
GR (1) | GR67655B (es) |
IL (1) | IL59620A (es) |
NO (1) | NO800743L (es) |
NZ (1) | NZ193129A (es) |
PT (1) | PT70951A (es) |
ZA (1) | ZA801520B (es) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4499079A (en) * | 1982-11-18 | 1985-02-12 | E. R. Squibb & Sons, Inc. | Carboxy and substituted carboxy alkanoyl and cycloalkanoyl peptides |
US4612302A (en) * | 1983-11-14 | 1986-09-16 | Brigham And Women's Hospital | Clinical use of somatostatin analogues |
US5504069A (en) * | 1993-02-11 | 1996-04-02 | Biomeasure, Inc. | Inhibition of trauma-induced tumor growth |
US5928896A (en) * | 1993-04-23 | 1999-07-27 | Virginia Commonwealth University | Polypeptides that include conformation-constraining groups which flank a protein--protein interaction site |
US5965698A (en) * | 1993-04-23 | 1999-10-12 | Virginia Commonwealth University | Polypeptides that include conformation-constraining groups which flank a protein--protein interaction site |
US5952465A (en) * | 1993-04-23 | 1999-09-14 | Virginia Commonwealth University | Polypeptides that include conformation-constraining groups which flank a protein-protein interaction site |
US6258550B1 (en) | 1993-04-23 | 2001-07-10 | Virginia Commonwealth University | Polypeptides that include conformation-constraining groups which flank a protein-protein interaction site |
AU6770794A (en) * | 1993-04-23 | 1994-11-21 | Herbert J. Evans | Polypeptides that include conformation-constraining groups which flank a protein-protein interaction site |
US6084066A (en) * | 1993-10-29 | 2000-07-04 | Virginia Commonwealth University | Polypetides that include conformation-constraining groups which flank a protein-protein interaction site |
US5597894A (en) * | 1995-06-05 | 1997-01-28 | The Louisiana State University Medical Center Foundation | Multi-tyrosinated somatostatin analogs |
PT980253E (pt) * | 1997-05-13 | 2004-08-31 | Conseils De Rec Appl Scient S | Somatostatina e agonistas de somatostatina para tratar a insensibilidade a insulina e a sindrome x |
US6004928A (en) * | 1997-05-13 | 1999-12-21 | Biomeasure, Incorporated | Method of treating hyperlipidemia |
ATE245998T1 (de) * | 1997-05-13 | 2003-08-15 | Sod Conseils Rech Applic | Somatostatin agoniste zur reduzierung von körpergewicht |
EP0981364B1 (en) * | 1997-05-13 | 2006-03-01 | Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. | Method and compositions for treating hyperlipidemia |
US5968903A (en) * | 1998-05-07 | 1999-10-19 | Biomeasure, Incorporated | Inhibition of H. pylori proliferation |
ES2325880T3 (es) | 2001-06-08 | 2009-09-23 | Ipsen Pharma | Analogos quimericos de somatostatina-dopamina. |
US8709998B2 (en) | 2003-04-22 | 2014-04-29 | Ipsen Pharma S.A.S. | Peptide vectors |
KR101642363B1 (ko) | 2008-06-12 | 2016-07-25 | 입센 바이오이노베이션 리미티드 | 신경내분비계 질환의 억제 |
CN102083451A (zh) | 2008-06-12 | 2011-06-01 | 赛恩泰新公司 | 癌症的抑制 |
GB0820970D0 (en) | 2008-11-17 | 2008-12-24 | Syntaxin Ltd | Suppression of cancer |
WO2014197938A1 (en) | 2013-06-13 | 2014-12-18 | Antisense Therapeutics Ltd | Combination therapy |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4020157A (en) * | 1975-07-08 | 1977-04-26 | Ayerst Mckenna And Harrison Ltd. | Shortened analogs of somatostatin |
US4372884A (en) * | 1975-08-06 | 1983-02-08 | The Salk Institute For Biological Studies | Pharmaceutically active peptides |
NL7607987A (nl) * | 1975-08-08 | 1977-02-10 | Merck & Co Inc | Werkwijze voor het bereiden van peptiden. |
US4122077A (en) * | 1976-12-17 | 1978-10-24 | American Home Products Corporation | Somatostatin analogs |
US4098782A (en) * | 1977-03-14 | 1978-07-04 | American Home Products Corporation | (His5)-somatostatin and analogues thereof |
US4115554A (en) * | 1977-08-29 | 1978-09-19 | Merck & Co., Inc. | Somatostatin analogs |
GB2019411B (en) * | 1978-04-24 | 1982-06-16 | American Home Prod | Peptides related to somatostatin |
-
1980
- 1980-03-10 US US06/129,066 patent/US4316890A/en not_active Expired - Lifetime
- 1980-03-13 AT AT80101310T patent/ATE3283T1/de not_active IP Right Cessation
- 1980-03-13 DE DE8080101310T patent/DE3063028D1/de not_active Expired
- 1980-03-13 DD DD80219646A patent/DD151059A5/de unknown
- 1980-03-13 EP EP80101310A patent/EP0017760B1/de not_active Expired
- 1980-03-14 GR GR61450A patent/GR67655B/el unknown
- 1980-03-14 FI FI800795A patent/FI800795A/fi not_active Application Discontinuation
- 1980-03-14 IL IL59620A patent/IL59620A/xx unknown
- 1980-03-14 ZA ZA00801520A patent/ZA801520B/xx unknown
- 1980-03-14 ES ES489565A patent/ES8103028A1/es not_active Expired
- 1980-03-14 JP JP3170980A patent/JPS55124748A/ja active Pending
- 1980-03-14 AU AU56462/80A patent/AU5646280A/en not_active Abandoned
- 1980-03-14 CA CA000347728A patent/CA1140117A/en not_active Expired
- 1980-03-14 NZ NZ193129A patent/NZ193129A/xx unknown
- 1980-03-14 PT PT70951A patent/PT70951A/pt unknown
- 1980-03-14 NO NO800743A patent/NO800743L/no unknown
- 1980-03-15 KR KR1019800001097A patent/KR830001872A/ko unknown
Also Published As
Publication number | Publication date |
---|---|
EP0017760A1 (de) | 1980-10-29 |
NZ193129A (en) | 1982-06-29 |
EP0017760B1 (de) | 1983-05-11 |
DD151059A5 (de) | 1981-09-30 |
KR830001872A (ko) | 1983-05-19 |
IL59620A0 (en) | 1980-06-30 |
DE3063028D1 (en) | 1983-06-16 |
IL59620A (en) | 1983-07-31 |
ES489565A0 (es) | 1981-02-16 |
JPS55124748A (en) | 1980-09-26 |
AU5646280A (en) | 1980-09-18 |
CA1140117A (en) | 1983-01-25 |
ZA801520B (en) | 1981-03-25 |
FI800795A (fi) | 1980-09-17 |
US4316890A (en) | 1982-02-23 |
NO800743L (no) | 1980-09-17 |
GR67655B (es) | 1981-09-02 |
ATE3283T1 (de) | 1983-05-15 |
PT70951A (en) | 1980-04-01 |
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