ES8102573A1 - A process for preparing pivaloyloxymethyl esters of 6- beta - amidinopenicillanic acids - Google Patents
A process for preparing pivaloyloxymethyl esters of 6- beta - amidinopenicillanic acidsInfo
- Publication number
- ES8102573A1 ES8102573A1 ES490521A ES490521A ES8102573A1 ES 8102573 A1 ES8102573 A1 ES 8102573A1 ES 490521 A ES490521 A ES 490521A ES 490521 A ES490521 A ES 490521A ES 8102573 A1 ES8102573 A1 ES 8102573A1
- Authority
- ES
- Spain
- Prior art keywords
- beta
- preparing
- amidinopenicillanic
- pivaloyloxymethyl esters
- acids
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000002253 acid Substances 0.000 title abstract 3
- 150000007513 acids Chemical class 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- -1 pivaloyloxymethyl esters Chemical class 0.000 title abstract 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 abstract 1
- NPGNOVNWUSPMDP-UTEPHESZSA-N chembl1650818 Chemical compound N(/[C@H]1[C@@H]2N(C1=O)[C@H](C(S2)(C)C)C(=O)OCOC(=O)C(C)(C)C)=C\N1CCCCCC1 NPGNOVNWUSPMDP-UTEPHESZSA-N 0.000 abstract 1
- GGRHYQCXXYLUTL-UHFFFAOYSA-N chloromethyl 2,2-dimethylpropanoate Chemical compound CC(C)(C)C(=O)OCCl GGRHYQCXXYLUTL-UHFFFAOYSA-N 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229960004212 pivmecillinam Drugs 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A process for preparing the pivaloyloxymethyl esters of 6- beta - amidinopenicillanic acids, in which a derivative of 6- beta -amidinopenicillanic acid is reacted with chloromethylpivalate in an aprotic dipolar solvent in the presence of an alkaline metal carbonate at a temperature of from +20 DEG to +40 DEG C. The process is carried out in high yield and is particularly useful for preparing the medicine pivmecillinam which has a pronounced antibiotic activity.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT21862/79A IT1119739B (en) | 1979-04-13 | 1979-04-13 | METHOD FOR THE PRODUCTION OF ESTERS OF 6-B-AMIDINE-PENICILLANIC ACID DERIVATIVES |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8102573A1 true ES8102573A1 (en) | 1981-02-16 |
| ES490521A0 ES490521A0 (en) | 1981-02-16 |
Family
ID=11187898
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES490521A Granted ES490521A0 (en) | 1979-04-13 | 1980-04-12 | A METHOD FOR THE PREPARATION OF PIVALOXIMETILESTER ACIDS 6-BETA-AMIDINOPENICILANICOS |
Country Status (9)
| Country | Link |
|---|---|
| JP (1) | JPS55147288A (en) |
| BE (1) | BE882556A (en) |
| DE (1) | DE3012666A1 (en) |
| DK (1) | DK154980A (en) |
| ES (1) | ES490521A0 (en) |
| FR (1) | FR2453863A1 (en) |
| GB (1) | GB2047689A (en) |
| IT (1) | IT1119739B (en) |
| NL (1) | NL8002107A (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114573603A (en) * | 2022-03-07 | 2022-06-03 | 南京美智德合成材料有限公司 | Process for synthesizing pimecrcillin in one pot |
-
1979
- 1979-04-13 IT IT21862/79A patent/IT1119739B/en active
-
1980
- 1980-03-19 GB GB8009291A patent/GB2047689A/en not_active Withdrawn
- 1980-03-28 FR FR8006992A patent/FR2453863A1/en not_active Withdrawn
- 1980-03-31 BE BE0/200056A patent/BE882556A/en unknown
- 1980-04-01 JP JP4125580A patent/JPS55147288A/en active Pending
- 1980-04-01 DE DE19803012666 patent/DE3012666A1/en not_active Withdrawn
- 1980-04-10 NL NL8002107A patent/NL8002107A/en not_active Application Discontinuation
- 1980-04-10 DK DK154980A patent/DK154980A/en not_active IP Right Cessation
- 1980-04-12 ES ES490521A patent/ES490521A0/en active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| FR2453863A1 (en) | 1980-11-07 |
| NL8002107A (en) | 1980-10-15 |
| BE882556A (en) | 1980-07-16 |
| JPS55147288A (en) | 1980-11-17 |
| IT7921862A0 (en) | 1979-04-13 |
| ES490521A0 (en) | 1981-02-16 |
| DE3012666A1 (en) | 1980-11-27 |
| DK154980A (en) | 1980-10-14 |
| GB2047689A (en) | 1980-12-03 |
| IT1119739B (en) | 1986-03-10 |
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