ES8102149A1 - Un procedimiento de preparacion de nuevos 19-nor-esteroides sustituidos en posicion 2 - Google Patents
Un procedimiento de preparacion de nuevos 19-nor-esteroides sustituidos en posicion 2Info
- Publication number
- ES8102149A1 ES8102149A1 ES486791A ES486791A ES8102149A1 ES 8102149 A1 ES8102149 A1 ES 8102149A1 ES 486791 A ES486791 A ES 486791A ES 486791 A ES486791 A ES 486791A ES 8102149 A1 ES8102149 A1 ES 8102149A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- steroids
- replaced
- procedure
- carbon atoms
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical group CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 206010019280 Heart failures Diseases 0.000 abstract 1
- 208000037849 arterial hypertension Diseases 0.000 abstract 1
- 238000006482 condensation reaction Methods 0.000 abstract 1
- RXPRRQLKFXBCSJ-UHFFFAOYSA-N dl-Vincamin Natural products C1=CC=C2C(CCN3CCC4)=C5C3C4(CC)CC(O)(C(=O)OC)N5C2=C1 RXPRRQLKFXBCSJ-UHFFFAOYSA-N 0.000 abstract 1
- 150000004820 halides Chemical class 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 150000003016 phosphoric acids Chemical class 0.000 abstract 1
- RIOQSEWOXXDEQQ-UHFFFAOYSA-O triphenylphosphanium Chemical compound C1=CC=CC=C1[PH+](C=1C=CC=CC=1)C1=CC=CC=C1 RIOQSEWOXXDEQQ-UHFFFAOYSA-O 0.000 abstract 1
- RXPRRQLKFXBCSJ-GIVPXCGWSA-N vincamine Chemical compound C1=CC=C2C(CCN3CCC4)=C5[C@@H]3[C@]4(CC)C[C@](O)(C(=O)OC)N5C2=C1 RXPRRQLKFXBCSJ-GIVPXCGWSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
- C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
- C07J7/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa
- C07J7/002—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa not substituted in position 16
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/006—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton spiro-condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- C07J5/0007—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa
- C07J5/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa not substituted in position 16
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
- C07J7/0065—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by an OH group free esterified or etherified
- C07J7/007—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by an OH group free esterified or etherified not substituted in position 17 alfa
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7835046A FR2444047A1 (fr) | 1978-12-13 | 1978-12-13 | Nouveaux derives 2,2-dimethyl 19-nor steroides, leur procede de preparation et leur application comme medicaments |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES486791A0 ES486791A0 (es) | 1980-12-16 |
| ES8102149A1 true ES8102149A1 (es) | 1980-12-16 |
Family
ID=9216044
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES486791A Expired ES8102149A1 (es) | 1978-12-13 | 1979-12-12 | Un procedimiento de preparacion de nuevos 19-nor-esteroides sustituidos en posicion 2 |
Country Status (14)
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994012523A1 (en) * | 1992-11-30 | 1994-06-09 | Mallinckrodt Medical, Inc. | Steroid-21-phosphate complex of technetium-99m |
| US20030083231A1 (en) * | 1998-11-24 | 2003-05-01 | Ahlem Clarence N. | Blood cell deficiency treatment method |
| FR2917975B1 (fr) * | 2007-06-26 | 2009-10-16 | Ceva Sante Animale Sa | Compositions et traitement de l'insuffisance cardiaque chez les animaux mammiferes non humains |
| US20090270356A1 (en) * | 2008-04-28 | 2009-10-29 | Ceva Sante Animale Sa | Compositions and treatments of heart failure in non-human mammal animals |
| WO2012058463A2 (en) | 2010-10-27 | 2012-05-03 | Dignity Health | Trimegestone (tmg) for treatment of preterm birth |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1138460A (en) * | 1965-06-01 | 1969-01-01 | Merck & Co Inc | Steroid compounds |
| FR1476572A (fr) * | 1965-09-13 | 1967-04-14 | Gonènes synthétiques et leur procédé de préparation | |
| FR2322606A1 (fr) * | 1975-09-02 | 1977-04-01 | Roussel Uclaf | Nouveaux 2,2-dimethyl steroides, leur procede de preparation et leur application comme medicament |
| FR2364655A1 (fr) * | 1976-09-17 | 1978-04-14 | Roussel Uclaf | Nouveaux 2,2-dimethyl 19-nor steroides, leur procede de preparation et leur application comme medicament |
-
1978
- 1978-12-13 FR FR7835046A patent/FR2444047A1/fr active Granted
-
1979
- 1979-11-14 EP EP79400873A patent/EP0012641B1/fr not_active Expired
- 1979-11-14 EP EP81200353A patent/EP0044575B1/fr not_active Expired
- 1979-11-16 ZA ZA00796194A patent/ZA796194B/xx unknown
- 1979-11-23 HU HU79RO1045A patent/HU180931B/hu not_active IP Right Cessation
- 1979-11-30 US US06/098,766 patent/US4263290A/en not_active Expired - Lifetime
- 1979-12-10 SU SU792850118A patent/SU1178325A3/ru active
- 1979-12-10 FI FI793847A patent/FI70027C/fi not_active IP Right Cessation
- 1979-12-11 PT PT70575A patent/PT70575A/pt unknown
- 1979-12-12 DK DK527379A patent/DK527379A/da not_active Application Discontinuation
- 1979-12-12 CA CA000341751A patent/CA1146531A/fr not_active Expired
- 1979-12-12 ES ES486791A patent/ES8102149A1/es not_active Expired
- 1979-12-12 AU AU53762/79A patent/AU527582B2/en not_active Ceased
- 1979-12-13 IE IE2420/79A patent/IE49235B1/en unknown
- 1979-12-13 JP JP16090879A patent/JPS5585598A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6337796B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1988-07-27 |
| EP0044575A1 (fr) | 1982-01-27 |
| EP0012641A3 (en) | 1980-09-17 |
| HU180931B (en) | 1983-05-30 |
| PT70575A (fr) | 1980-01-01 |
| EP0012641A2 (fr) | 1980-06-25 |
| FR2444047B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1982-05-28 |
| SU1178325A3 (ru) | 1985-09-07 |
| FI70027B (fi) | 1986-01-31 |
| FI793847A7 (fi) | 1980-06-14 |
| DK527379A (da) | 1980-06-14 |
| US4263290A (en) | 1981-04-21 |
| AU527582B2 (en) | 1983-03-10 |
| EP0012641B1 (fr) | 1982-05-12 |
| AU5376279A (en) | 1980-07-10 |
| ES486791A0 (es) | 1980-12-16 |
| FR2444047A1 (fr) | 1980-07-11 |
| IE792420L (en) | 1980-06-13 |
| JPS5585598A (en) | 1980-06-27 |
| FI70027C (fi) | 1986-09-12 |
| IE49235B1 (en) | 1985-09-04 |
| EP0044575B1 (fr) | 1984-03-21 |
| ZA796194B (en) | 1980-11-26 |
| CA1146531A (fr) | 1983-05-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Patent lapsed |
Effective date: 19960506 |