ES484287A1 - Procedure for the obtaining of N- (1- (4-amino-2-quinazolinil) -3-0-4-piperidil-lactamas. (Machine-translation by Google Translate, not legally binding) - Google Patents
Procedure for the obtaining of N- (1- (4-amino-2-quinazolinil) -3-0-4-piperidil-lactamas. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES484287A1 ES484287A1 ES484287A ES484287A ES484287A1 ES 484287 A1 ES484287 A1 ES 484287A1 ES 484287 A ES484287 A ES 484287A ES 484287 A ES484287 A ES 484287A ES 484287 A1 ES484287 A1 ES 484287A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- racemates
- alkylene
- acid addition
- translation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Landscapes
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
1. Process for obtaining N- [1- (4-amino-2-quinazolipyl) -3- or -4-piperidyl] -lactams of general formula i ** (formula i) ** where ph means a residue 1, 2-phenylene, which may optionally be substituted by at most 3 substituents selected from lower alkyl and lower alkoxy and a lower alkylenedioxy, each of the symbols m and n represents an integer from 1 to 3, where mn = 4, x means 2 hydrogen atoms or oxo, and a means lower alkylene, cycloalkylene containing 4 to 7 ring members, lower cyanoalkylamino and lower spirocycloalkane-alkylene, lower nph-alkylene or ph, and their acid addition salts, characterized because compounds of formulas iii and iv ** (formula iii and iv) ** are condensed, where y means halogen or lower alkylthio and m is by hydrogen or an alkali metal atom, and, if desired, a compound obtained from formula i is transformed into another compound according to the present in tion, and/or, if desired, a free compound obtained is transformed into an acid addition salt or an acid addition salt in the free compound or in another salt, and/or, if desired, a mixture obtained of isomers or racemates is separated into the different isomers or racemates, and/or, if desired, the racemates obtained are dissociated to the optical antipodes. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US94405778A | 1978-09-20 | 1978-09-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES484287A1 true ES484287A1 (en) | 1980-05-16 |
Family
ID=25480720
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES484287A Expired ES484287A1 (en) | 1978-09-20 | 1979-09-19 | Procedure for the obtaining of N- (1- (4-amino-2-quinazolinil) -3-0-4-piperidil-lactamas. (Machine-translation by Google Translate, not legally binding) |
Country Status (12)
| Country | Link |
|---|---|
| CS (1) | CS210700B2 (en) |
| DD (1) | DD146185A5 (en) |
| DK (1) | DK390579A (en) |
| ES (1) | ES484287A1 (en) |
| FI (1) | FI792917A (en) |
| GR (1) | GR72954B (en) |
| IL (1) | IL58269A0 (en) |
| NO (1) | NO793009L (en) |
| PL (1) | PL218431A1 (en) |
| PT (1) | PT70202A (en) |
| SU (1) | SU873882A3 (en) |
| ZA (2) | ZA793938B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5635517B1 (en) * | 1996-07-24 | 1999-06-29 | Celgene Corp | Method of reducing TNFalpha levels with amino substituted 2-(2,6-dioxopiperidin-3-YL)-1-oxo-and 1,3-dioxoisoindolines |
-
1979
- 1979-07-31 ZA ZA00793938A patent/ZA793938B/en unknown
- 1979-09-18 IL IL58269A patent/IL58269A0/en unknown
- 1979-09-18 GR GR60058A patent/GR72954B/el unknown
- 1979-09-18 DD DD21561179A patent/DD146185A5/en unknown
- 1979-09-19 ES ES484287A patent/ES484287A1/en not_active Expired
- 1979-09-19 DK DK390579A patent/DK390579A/en unknown
- 1979-09-19 ZA ZA00794973A patent/ZA794973B/en unknown
- 1979-09-19 SU SU792817257A patent/SU873882A3/en active
- 1979-09-19 NO NO793009A patent/NO793009L/en unknown
- 1979-09-19 FI FI792917A patent/FI792917A/en not_active Application Discontinuation
- 1979-09-20 CS CS635479A patent/CS210700B2/en unknown
- 1979-09-20 PL PL21843179A patent/PL218431A1/xx unknown
- 1979-09-20 PT PT7020279A patent/PT70202A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL58269A0 (en) | 1979-12-30 |
| ZA794973B (en) | 1980-08-27 |
| NO793009L (en) | 1980-03-21 |
| PT70202A (en) | 1979-10-01 |
| FI792917A (en) | 1980-03-21 |
| CS210700B2 (en) | 1982-01-29 |
| PL218431A1 (en) | 1980-06-16 |
| GR72954B (en) | 1984-01-18 |
| SU873882A3 (en) | 1981-10-15 |
| ZA793938B (en) | 1980-07-30 |
| DD146185A5 (en) | 1981-01-28 |
| DK390579A (en) | 1980-03-21 |
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