ES483798A1 - Un procedimiento para la preparacion de nuevos derivados de hidantoina - Google Patents

Un procedimiento para la preparacion de nuevos derivados de hidantoina

Info

Publication number
ES483798A1
ES483798A1 ES483798A ES483798A ES483798A1 ES 483798 A1 ES483798 A1 ES 483798A1 ES 483798 A ES483798 A ES 483798A ES 483798 A ES483798 A ES 483798A ES 483798 A1 ES483798 A1 ES 483798A1
Authority
ES
Spain
Prior art keywords
alkyl
preparation
pharmaceutical compositions
compositions containing
thiohydantoins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES483798A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of ES483798A1 publication Critical patent/ES483798A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/86—Oxygen and sulfur atoms, e.g. thiohydantoin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C07D233/76—Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Un procedimiento para la preparación de nuevos derivados de hidatoina de fórmula I: **(Fórmula)** donde X es O o S; R1 es hidrógeno o CO2R1 representa un grupo éster donde el radical R1 contiene de 1 a 12 átomos de carbono; R2 es hidrógeno o alquilo C1- 4; R4 es alquilo C1-9, cicloalquilo C3-8 o cicloalquil (C3-8)-alquilo (C1-6) o R2 y R4 junto con el átomo de carbono al que están unidos representan un grupo cicloalquilo C5-8 y R5 es alquilo C1-6.
ES483798A 1978-01-23 1979-08-31 Un procedimiento para la preparacion de nuevos derivados de hidantoina Expired ES483798A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB269478 1978-01-23
GB1923278 1978-05-12

Publications (1)

Publication Number Publication Date
ES483798A1 true ES483798A1 (es) 1980-04-16

Family

ID=26237673

Family Applications (2)

Application Number Title Priority Date Filing Date
ES477092A Expired ES477092A1 (es) 1978-01-23 1979-01-23 Un procedimiento para la preparacion de nuevos derivados de hidantoina.
ES483798A Expired ES483798A1 (es) 1978-01-23 1979-08-31 Un procedimiento para la preparacion de nuevos derivados de hidantoina

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES477092A Expired ES477092A1 (es) 1978-01-23 1979-01-23 Un procedimiento para la preparacion de nuevos derivados de hidantoina.

Country Status (7)

Country Link
US (1) US4298745A (es)
EP (1) EP0003410B1 (es)
AU (1) AU524991B2 (es)
CA (1) CA1124731A (es)
DE (1) DE2963795D1 (es)
DK (1) DK27179A (es)
ES (2) ES477092A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55151569A (en) * 1979-05-09 1980-11-26 Wellcome Found Optically active heterocyclic compounds* their synthesis and medical blend containing them
EP2765860B1 (en) 2011-10-13 2016-08-17 Merck Sharp & Dohme Corp. Mineralocorticoid receptor antagonists
US9085568B2 (en) 2011-10-13 2015-07-21 Merck Sharp & Dohme Corp. Mineralocorticoid receptor antagonists
US9505730B2 (en) 2011-10-13 2016-11-29 Merck Sharp & Dohme Corp. Mineralocorticoid receptor antagonists

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2323193A1 (de) * 1972-05-10 1973-11-22 Du Pont Pyrazolidinone
US3873566A (en) * 1973-02-28 1975-03-25 Du Pont 3-Pyrazolidinones and pyrazolidines
FR2362839A1 (fr) * 1976-06-03 1978-03-24 Wellcome Found Derives de l'hydantoine et medicaments contenant ces substances
IL53559A0 (en) * 1976-12-18 1978-03-10 Beecham Group Ltd Novel prostaglandin analogues their preparation and pharmaceutical compositions containing them
US4152445A (en) * 1976-12-18 1979-05-01 Beecham Group Limited 1-(3-Hydroxyalk-1-yl)-5-(carboxyalkyl)hydantoin derivatives

Also Published As

Publication number Publication date
DK27179A (da) 1979-07-24
AU4354979A (en) 1979-08-02
CA1124731A (en) 1982-06-01
EP0003410B1 (en) 1982-10-06
AU524991B2 (en) 1982-10-14
EP0003410A1 (en) 1979-08-08
US4298745A (en) 1981-11-03
ES477092A1 (es) 1980-01-16
DE2963795D1 (en) 1982-11-11

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