ES483734A1 - Procedimiento para la preparacion de nuevos derivados de a- cidos carboxilicos- -alcoholes, halogenados - Google Patents

Procedimiento para la preparacion de nuevos derivados de a- cidos carboxilicos- -alcoholes, halogenados

Info

Publication number
ES483734A1
ES483734A1 ES483734A ES483734A ES483734A1 ES 483734 A1 ES483734 A1 ES 483734A1 ES 483734 A ES483734 A ES 483734A ES 483734 A ES483734 A ES 483734A ES 483734 A1 ES483734 A1 ES 483734A1
Authority
ES
Spain
Prior art keywords
halogenated
delta
preparation
acid derivatives
hydroxycarboxylic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES483734A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Laboratoires Hoechst SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR7825457A external-priority patent/FR2435459A1/fr
Priority claimed from FR7915888A external-priority patent/FR2459222A2/fr
Application filed by Laboratoires Hoechst SA filed Critical Laboratoires Hoechst SA
Publication of ES483734A1 publication Critical patent/ES483734A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/56—Unsaturated compounds containing hydroxy or O-metal groups containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/84—Unsaturated compounds containing keto groups containing six membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Procedimiento para la preparación de nuevos derivados de ácidos carboxílicos-delta-alcoholes, halogenados, caracterizados porque responden a la fórmula general siguiente: **(Fórmula-01)** (forma abierta, en medio básico) o a la fórmula general IIIb siguiente:**(Fórmula-02)** (forma ciclizada, en medio ácido) en las cuales: X1 y X2 son átomos de halógeno, n1 y n2 son números enteros comprendidos entre 0 y 5, pero si n1 = 0, n2 es diferente de 0 y a la inversa; R es un átomo de hidrógeno, un grupo alcohilo o arilo, Catión representa un ión que proviene de una base o un ión metálico, farmacéuticamente compatibles, caracterizado porque en el curso de una primera otana se prepara un cetonitrilo halogenado, que seguidamente se transforma por hidrólisis y reducción en el compuesto de fórmula general III correspondiente, de forma abierta (a) en medio básico o de forma ciclizada (b) en medio ácido.
ES483734A 1978-09-05 1979-08-30 Procedimiento para la preparacion de nuevos derivados de a- cidos carboxilicos- -alcoholes, halogenados Expired ES483734A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR7825457A FR2435459A1 (fr) 1978-09-05 1978-09-05 Nouveaux derives d'acides carboxyliques d-alcools, halogenes, leurs procedes de preparation et medicaments les contenant
FR7915888A FR2459222A2 (fr) 1979-06-21 1979-06-21 Perfectionnements apportes aux procedes de preparation de derives d'acides carboxyliques d-alcools, halogenes, produits obtenus par ces procedes, et medicaments contenant ces produits

Publications (1)

Publication Number Publication Date
ES483734A1 true ES483734A1 (es) 1980-05-16

Family

ID=26220741

Family Applications (1)

Application Number Title Priority Date Filing Date
ES483734A Expired ES483734A1 (es) 1978-09-05 1979-08-30 Procedimiento para la preparacion de nuevos derivados de a- cidos carboxilicos- -alcoholes, halogenados

Country Status (8)

Country Link
US (1) US4287206A (es)
EP (1) EP0009153B1 (es)
AR (1) AR228727A1 (es)
AU (1) AU530498B2 (es)
CA (1) CA1181409A (es)
DE (1) DE2961010D1 (es)
ES (1) ES483734A1 (es)
MA (1) MA18559A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3306960A1 (de) * 1983-02-28 1984-08-30 Merck Patent Gmbh, 6100 Darmstadt Tetrahydropyrane

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH315583A (fr) * 1952-04-30 1956-08-31 Distillers Co Yeast Ltd Procédé de préparation de lactones non saturées
BE643891A (es) * 1964-02-17 1964-08-17
FR2314186A1 (fr) * 1975-06-13 1977-01-07 Ucc Union Chimique Cont Nouveau procede de preparation des a-pyrones
US4163799A (en) * 1975-06-13 1979-08-07 Union Chimique Continentale U.C.C. Psychostimulant compounds
FR2373281A2 (fr) * 1976-12-08 1978-07-07 Ucc Union Chimique Cont Nouveaux medicaments psychostimulants
JPS53147073A (en) * 1977-05-24 1978-12-21 Sankyo Co Ltd Mevalonolactone derivatives

Also Published As

Publication number Publication date
AU530498B2 (en) 1983-07-21
CA1181409A (en) 1985-01-22
MA18559A1 (fr) 1980-04-01
EP0009153A1 (de) 1980-04-02
EP0009153B1 (de) 1981-10-14
DE2961010D1 (en) 1981-12-24
AR228727A1 (es) 1983-04-15
US4287206A (en) 1981-09-01
AU5054979A (en) 1980-03-13

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19971001