ES481522A1 - Hydrocortisone derivatives, their preparation and pharmaceutical compositions containing them - Google Patents

Hydrocortisone derivatives, their preparation and pharmaceutical compositions containing them

Info

Publication number
ES481522A1
ES481522A1 ES481522A ES481522A ES481522A1 ES 481522 A1 ES481522 A1 ES 481522A1 ES 481522 A ES481522 A ES 481522A ES 481522 A ES481522 A ES 481522A ES 481522 A1 ES481522 A1 ES 481522A1
Authority
ES
Spain
Prior art keywords
preparation
pharmaceutical compositions
compositions containing
hydrocortisone derivatives
hydrocortisone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES481522A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Galderma SA
Original Assignee
Beiersdorf AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beiersdorf AG filed Critical Beiersdorf AG
Publication of ES481522A1 publication Critical patent/ES481522A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0053—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Abstract

The invention provides hydrocortisone-17, 21-diesters of the general formula < IMAGE > wherein each of R<1> and R<2>, which may be the same or different, represents a straight or branched chain alkyl group containing 1 to 5 carbon atoms. These diesters have good stability and valuable therapeutic properties such as good anti-phlogistic action as well as low toxicity.
ES481522A 1978-06-15 1979-06-13 Hydrocortisone derivatives, their preparation and pharmaceutical compositions containing them Expired ES481522A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2826257A DE2826257C3 (en) 1978-06-15 1978-06-15 Hydrocortisone-17,21-diester and process for their preparation, pharmaceuticals containing them and hydrocortisone -17-propionate as an intermediate

Publications (1)

Publication Number Publication Date
ES481522A1 true ES481522A1 (en) 1980-01-16

Family

ID=6041871

Family Applications (1)

Application Number Title Priority Date Filing Date
ES481522A Expired ES481522A1 (en) 1978-06-15 1979-06-13 Hydrocortisone derivatives, their preparation and pharmaceutical compositions containing them

Country Status (11)

Country Link
JP (1) JPS5540662A (en)
AT (1) AT368757B (en)
AU (1) AU4760479A (en)
BE (1) BE877017A (en)
CA (1) CA1135253A (en)
CH (1) CH641476A5 (en)
DE (1) DE2826257C3 (en)
ES (1) ES481522A1 (en)
FR (1) FR2428649A1 (en)
GB (1) GB2023145A (en)
ZA (1) ZA792952B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6040439B2 (en) * 1978-03-29 1985-09-11 大正製薬株式会社 hydrocortisone derivatives
JPS59137408A (en) * 1983-01-27 1984-08-07 Taisho Pharmaceut Co Ltd Ointment
AT389447B (en) * 1983-01-27 1989-12-11 Taisho Pharmaceutical Co Ltd Process for the production of a topical steroid ointment
JPS59139315A (en) * 1983-01-31 1984-08-10 Taisho Pharmaceut Co Ltd Cream agent
DE3534742A1 (en) * 1985-09-28 1987-04-09 Beiersdorf Ag HYDROCORTISON'S MOST CONTAINING W / O CREAM
DE3534743A1 (en) * 1985-09-28 1987-04-02 Beiersdorf Ag HYDROCORTISON'S BEST CONTAINING O / W CREAM
DE4345186C2 (en) * 1993-12-27 1997-08-14 Galderma Sa Hydrocortisone 21-acetate-17-propionate containing W / O lotions

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2144405A1 (en) * 1971-09-04 1973-03-08 Merck Patent Gmbh Saponification of pregnane series esters - using silica gel
SU427930A1 (en) * 1972-03-16 1974-05-15 А. А. Ахрем, И. С. Левина , Ю. А. Титов Институт органической химии Н. Д. Зелинского METHOD FOR OBTAINING DERIVATIVE CORTICOSTEROIDS
JPS6040439B2 (en) * 1978-03-29 1985-09-11 大正製薬株式会社 hydrocortisone derivatives

Also Published As

Publication number Publication date
CH641476A5 (en) 1984-02-29
BE877017A (en) 1979-12-17
JPS5540662A (en) 1980-03-22
ATA422179A (en) 1982-03-15
GB2023145A (en) 1979-12-28
CA1135253A (en) 1982-11-09
DE2826257A1 (en) 1979-12-20
ZA792952B (en) 1980-06-25
AT368757B (en) 1982-11-10
DE2826257B2 (en) 1980-03-06
DE2826257C3 (en) 1980-12-04
FR2428649A1 (en) 1980-01-11
AU4760479A (en) 1979-12-20
FR2428649B1 (en) 1982-06-11

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Legal Events

Date Code Title Description
PC2A Transfer of patent

Owner name: GALDERMA, S.A.