ES480147A1 - Un procedimiento para la preparacion de derivados del acido pseudomonico. - Google Patents

Un procedimiento para la preparacion de derivados del acido pseudomonico.

Info

Publication number
ES480147A1
ES480147A1 ES480147A ES480147A ES480147A1 ES 480147 A1 ES480147 A1 ES 480147A1 ES 480147 A ES480147 A ES 480147A ES 480147 A ES480147 A ES 480147A ES 480147 A1 ES480147 A1 ES 480147A1
Authority
ES
Spain
Prior art keywords
pseudomonic acid
esters
pharmaceutical
processes
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES480147A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of ES480147A1 publication Critical patent/ES480147A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/38—Pseudomonas
    • C12R2001/39—Pseudomonas fluorescens
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/874—Pseudomonas
    • Y10S435/876—Pseudomonas fluorescens

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pyrane Compounds (AREA)

Abstract

1. Un procedimiento para la preparación de derivados del ácido pseudomónico de fórmula II **(Fórmula)** o una sal o éster farmacéuticamente aceptable; cuyo procedimiento comprende cultivar Pseudomonas fluorescens bajo condiciones aeróbicas o en un medio de cultivo conteniendo sales inorgánicas y fuentes de carbono y nitrógeno asimilables, hasta que el medio de cultivo presenta, al menos, una actividad antibacteriana detectable, acidificación del medio de cultivo, extracción, con un disolvente orgánico de los materiales activos disueltos en el medio de cultivo, y después, someter a reacción de esterificación los materiales activos, separar un éster de ácido pseudomónico C de ésteres de cualesquiera otros materiales activos y, opcionalmente, someter a reacción de hidrólisis el éster separado para formar el ácido pseudomónico C o una sal del mismo.
ES480147A 1977-11-01 1979-05-02 Un procedimiento para la preparacion de derivados del acido pseudomonico. Expired ES480147A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB4530577 1977-11-01

Publications (1)

Publication Number Publication Date
ES480147A1 true ES480147A1 (es) 1980-05-16

Family

ID=10436710

Family Applications (3)

Application Number Title Priority Date Filing Date
ES474733A Expired ES474733A1 (es) 1977-11-01 1978-10-31 Un procedimiento para la preparacion de derivados del acido pseudomonico.
ES480146A Expired ES480146A1 (es) 1977-11-01 1979-05-02 Un procedimiento para la preparacion de derivados del acido pseudomonico.
ES480147A Expired ES480147A1 (es) 1977-11-01 1979-05-02 Un procedimiento para la preparacion de derivados del acido pseudomonico.

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES474733A Expired ES474733A1 (es) 1977-11-01 1978-10-31 Un procedimiento para la preparacion de derivados del acido pseudomonico.
ES480146A Expired ES480146A1 (es) 1977-11-01 1979-05-02 Un procedimiento para la preparacion de derivados del acido pseudomonico.

Country Status (13)

Country Link
US (2) US4205002A (es)
EP (1) EP0003069B1 (es)
JP (1) JPS5495574A (es)
AT (1) AT365182B (es)
AU (1) AU526259B2 (es)
DE (1) DE2860724D1 (es)
DK (1) DK486478A (es)
ES (3) ES474733A1 (es)
FI (1) FI783282A (es)
IE (1) IE47478B1 (es)
IT (1) IT1109385B (es)
NZ (1) NZ188786A (es)
ZA (1) ZA786114B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2960718D1 (en) * 1978-04-21 1981-11-26 Beecham Group Plc Antibacterial monic acid c derivatives, processes for their preparation and compositions containing them
EP0042233A1 (en) * 1980-06-14 1981-12-23 Beecham Group Plc 13-oxo-monic acid and its salts and esters, process for their production, and compositions containing them
JPS6020000B2 (ja) * 1980-07-07 1985-05-18 ウェルファイド株式会社 新抗生物質ｙ−１６４８２物質およびその製造法
US4952604A (en) * 1989-05-03 1990-08-28 Merck & Co., Inc. Antifungal agent
US5214067A (en) * 1990-09-17 1993-05-25 Merck & Co., Inc. Fungicidal compositions and method
GB9313796D0 (en) * 1993-07-03 1993-08-18 Smithkline Beecham Plc Novel bioprocess
IL150907A (en) * 2002-07-25 2007-07-04 Stephan Cherkez Process for the preparation of stable amorphous calcium pseudomonate
JP4771318B2 (ja) * 2009-02-02 2011-09-14 株式会社吉野工業所 ヒンジ蓋体の射出成形金型

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL30058A (en) * 1967-08-10 1972-09-28 Lilly Co Eli Process for preparing antibiotic a10388(pyrrolnitrin)
GB1395907A (en) * 1971-06-12 1975-05-29 Beecham Group Ltd Antibiotics
US4071536A (en) * 1971-06-12 1978-01-31 Beecham Group Limited Antibiotics
GB1587058A (en) * 1976-06-15 1981-03-25 Beecham Group Ltd Oxiranylmethyltetrahydropyran derivatives

Also Published As

Publication number Publication date
ZA786114B (en) 1979-10-31
ES480146A1 (es) 1980-04-01
AT365182B (de) 1981-12-28
ATA779378A (de) 1981-05-15
JPS6259701B2 (es) 1987-12-12
NZ188786A (en) 1980-08-26
FI783282A (fi) 1979-05-02
ES474733A1 (es) 1980-12-16
IE782151L (en) 1979-05-01
DK486478A (da) 1979-05-02
AU526259B2 (en) 1982-12-23
IT7851723A0 (it) 1978-10-31
DE2860724D1 (en) 1981-08-27
EP0003069B1 (en) 1981-05-20
EP0003069A1 (en) 1979-07-25
IE47478B1 (en) 1984-03-21
IT1109385B (it) 1985-12-16
JPS5495574A (en) 1979-07-28
AU4126678A (en) 1979-05-17
US4226880A (en) 1980-10-07
US4205002A (en) 1980-05-27

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