ES478612A1 - Procedimiento para preparar alfa-halometil derivados de al- fa-amino acidos. - Google Patents
Procedimiento para preparar alfa-halometil derivados de al- fa-amino acidos.Info
- Publication number
- ES478612A1 ES478612A1 ES478612A ES478612A ES478612A1 ES 478612 A1 ES478612 A1 ES 478612A1 ES 478612 A ES478612 A ES 478612A ES 478612 A ES478612 A ES 478612A ES 478612 A1 ES478612 A1 ES 478612A1
- Authority
- ES
- Spain
- Prior art keywords
- alpha
- lactam
- amino acid
- halomethyl derivative
- methylthioethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000001413 amino acids Chemical class 0.000 title 1
- 150000003951 lactams Chemical class 0.000 title 1
- -1 β-methylthioethyl Chemical group 0.000 abstract 4
- 150000001371 alpha-amino acids Chemical class 0.000 abstract 1
- 235000008206 alpha-amino acids Nutrition 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/20—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
- C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/74—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/74—Oxygen atoms
- C07D211/76—Oxygen atoms attached in position 2 or 6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D223/08—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
Procedimiento para preparar alfa-halometil derivados de alfa-amino ácidos, de la fórmula *** ver imagen 01 en que Y es FCH2-, F2CH-, F3C-, ClCH2- o CL2CH-, Z es beta-metiltioetilo, beta-tioetilo, beta-benciltioetilo, S-(5¿-desoxiadenosin-5¿-ilo)-S-metiltioetilo, gamma-guanidinopropilo, o RaHN(CH2)n-n es el número entero 3 ó 4 ó *** ver imagen 02
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US81476577A | 1977-07-11 | 1977-07-11 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES478612A1 true ES478612A1 (es) | 1979-09-16 |
Family
ID=25215950
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES471596A Expired ES471596A1 (es) | 1977-07-11 | 1978-07-10 | Procedimiento para preparar alfa-halometil derivados de al- fa-amino acidos |
ES478612A Expired ES478612A1 (es) | 1977-07-11 | 1979-03-14 | Procedimiento para preparar alfa-halometil derivados de al- fa-amino acidos. |
ES478611A Expired ES478611A1 (es) | 1977-07-11 | 1979-03-14 | Procedimiento para preparar alfa-halometil derivados de al- fa-amino acidos. |
ES478610A Expired ES478610A1 (es) | 1977-07-11 | 1979-03-14 | Procedimiento para preparar alfa-halometil derivados de al- fa-amino acidos. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES471596A Expired ES471596A1 (es) | 1977-07-11 | 1978-07-10 | Procedimiento para preparar alfa-halometil derivados de al- fa-amino acidos |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES478611A Expired ES478611A1 (es) | 1977-07-11 | 1979-03-14 | Procedimiento para preparar alfa-halometil derivados de al- fa-amino acidos. |
ES478610A Expired ES478610A1 (es) | 1977-07-11 | 1979-03-14 | Procedimiento para preparar alfa-halometil derivados de al- fa-amino acidos. |
Country Status (10)
Country | Link |
---|---|
JP (1) | JPS63246365A (es) |
DK (1) | DK148322C (es) |
ES (4) | ES471596A1 (es) |
HK (1) | HK76986A (es) |
IE (1) | IE47081B1 (es) |
IL (1) | IL54912A (es) |
IT (1) | IT1105099B (es) |
NZ (1) | NZ187536A (es) |
SE (1) | SE444934B (es) |
ZA (1) | ZA783349B (es) |
-
1978
- 1978-06-06 IE IE1146/78A patent/IE47081B1/en not_active IP Right Cessation
- 1978-06-12 ZA ZA00783349A patent/ZA783349B/xx unknown
- 1978-06-13 NZ NZ187536A patent/NZ187536A/xx unknown
- 1978-06-15 IL IL54912A patent/IL54912A/xx unknown
- 1978-07-10 SE SE7807691A patent/SE444934B/sv not_active IP Right Cessation
- 1978-07-10 DK DK309478A patent/DK148322C/da not_active IP Right Cessation
- 1978-07-10 IT IT50231/78A patent/IT1105099B/it active
- 1978-07-10 ES ES471596A patent/ES471596A1/es not_active Expired
-
1979
- 1979-03-14 ES ES478612A patent/ES478612A1/es not_active Expired
- 1979-03-14 ES ES478611A patent/ES478611A1/es not_active Expired
- 1979-03-14 ES ES478610A patent/ES478610A1/es not_active Expired
-
1986
- 1986-10-09 HK HK769/86A patent/HK76986A/xx not_active IP Right Cessation
-
1987
- 1987-12-28 JP JP62330367A patent/JPS63246365A/ja active Granted
Also Published As
Publication number | Publication date |
---|---|
ZA783349B (en) | 1979-06-27 |
IE781146L (en) | 1979-01-11 |
ES478611A1 (es) | 1979-07-16 |
IE47081B1 (en) | 1983-12-14 |
JPH0325424B2 (es) | 1991-04-05 |
IL54912A0 (en) | 1978-08-31 |
NZ187536A (en) | 1982-03-23 |
JPS63246365A (ja) | 1988-10-13 |
ES471596A1 (es) | 1979-10-01 |
IT7850231A0 (it) | 1978-07-10 |
ES478610A1 (es) | 1979-07-16 |
HK76986A (en) | 1986-10-17 |
DK148322B (da) | 1985-06-10 |
SE7807691L (sv) | 1979-01-12 |
DK148322C (da) | 1985-11-04 |
IT1105099B (it) | 1985-10-28 |
IL54912A (en) | 1984-11-30 |
SE444934B (sv) | 1986-05-20 |
DK309478A (da) | 1979-01-12 |
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