ES478526A1 - Procedimiento para la preparacion del acido 7-(d-&-amino-(4-hidroxifenil)-acetamido-3-metil-3-cefem-4-carboxilico. - Google Patents

Procedimiento para la preparacion del acido 7-(d-&-amino-(4-hidroxifenil)-acetamido-3-metil-3-cefem-4-carboxilico.

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Publication number
ES478526A1
ES478526A1 ES478526A ES478526A ES478526A1 ES 478526 A1 ES478526 A1 ES 478526A1 ES 478526 A ES478526 A ES 478526A ES 478526 A ES478526 A ES 478526A ES 478526 A1 ES478526 A1 ES 478526A1
Authority
ES
Spain
Prior art keywords
acid
amino
methyl
acetamido
translation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES478526A
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English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medea Research SRL
Original Assignee
Medea Research SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medea Research SRL filed Critical Medea Research SRL
Publication of ES478526A1 publication Critical patent/ES478526A1/es
Expired legal-status Critical Current

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Abstract

Procedimiento para la preparación del ácido 7-[D-alfa-amino- (4-hidroxifenil)-acetamido]-3-metil-3-cefem-4-carboxílico, particularmente de fórmula **(Fórmula 1)** caracterizado porque se hace reaccionar el anhídrido mixto de un ácido D-alfa-[(2-alcoxicarbonil-1-metil-venil)amino]-2- (4- trimetilsililoxi-fenil)-acético (IV) con el trimetil- sililéster del ácido 7-(n-trimetilsilil-amino)-desacetoxi- cefalosporánico (V), según el esquema: **(Fórmula 2)** donde R y R'', iguales o diferentes entre sí, representan residuos alquílico inferiores, preferentemente metilo o etilo, y porque el producto de reacción (VI), aislado como sal sódica, es finalmente sometido a hidrólisis ácida a fin de liberar la función anímica que la protege.
ES478526A 1978-03-01 1979-02-28 Procedimiento para la preparacion del acido 7-(d-&-amino-(4-hidroxifenil)-acetamido-3-metil-3-cefem-4-carboxilico. Expired ES478526A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT20779/78A IT1095469B (it) 1978-03-01 1978-03-01 Processo per la preparazione dell'acido 7-aperta par.quadrata d-alfa-ammino-(4-idrossifenil)-acetammido chiusa par.quadrata-3-metil-3-cefem-4-carbossilico

Publications (1)

Publication Number Publication Date
ES478526A1 true ES478526A1 (es) 1980-08-16

Family

ID=11171938

Family Applications (1)

Application Number Title Priority Date Filing Date
ES478526A Expired ES478526A1 (es) 1978-03-01 1979-02-28 Procedimiento para la preparacion del acido 7-(d-&-amino-(4-hidroxifenil)-acetamido-3-metil-3-cefem-4-carboxilico.

Country Status (2)

Country Link
ES (1) ES478526A1 (es)
IT (1) IT1095469B (es)

Also Published As

Publication number Publication date
IT1095469B (it) 1985-08-10
IT7820779A0 (it) 1978-03-01

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FD1A Patent lapsed

Effective date: 20001009