ES477355A1 - Procedimiento para la preparacion de 4-pirimidilsulfuros. - Google Patents

Procedimiento para la preparacion de 4-pirimidilsulfuros.

Info

Publication number
ES477355A1
ES477355A1 ES477355A ES477355A ES477355A1 ES 477355 A1 ES477355 A1 ES 477355A1 ES 477355 A ES477355 A ES 477355A ES 477355 A ES477355 A ES 477355A ES 477355 A1 ES477355 A1 ES 477355A1
Authority
ES
Spain
Prior art keywords
pyrimidyl
sulfides
treatment
gastric ulcers
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES477355A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Poli Industria Chimica SpA
Original Assignee
Poli Industria Chimica SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Poli Industria Chimica SpA filed Critical Poli Industria Chimica SpA
Publication of ES477355A1 publication Critical patent/ES477355A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nutrition Science (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Procedimiento para la preparación de 4-pirimidilsulfuros , de la fórmula general (I) *** ver imagen 01 en donde R y R1, que pueden ser iguales o distintos, representan H, NH2 o CH3 que constituyen el principio activo en la obtención de composiciones farmacéuticas con actividad antiulcórica, caracterizado porque se hace reaccionar la sal alcalina de una 4-mercaptopirimidina (II) con 3-clorometilpiridina-N-oxido (III), según el esquema *** ver imagen 02 donde Mc , representa un metal alcalino, de preferencia sodio.
ES477355A 1978-02-02 1979-02-01 Procedimiento para la preparacion de 4-pirimidilsulfuros. Expired ES477355A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT19905/78A IT1092343B (it) 1978-02-02 1978-02-02 Pirimidilsolfuri ad attivita' antisecretoria,processo per la loro preparazione e composizioni farmaceutiche che li contengono

Publications (1)

Publication Number Publication Date
ES477355A1 true ES477355A1 (es) 1979-10-16

Family

ID=11162221

Family Applications (1)

Application Number Title Priority Date Filing Date
ES477355A Expired ES477355A1 (es) 1978-02-02 1979-02-01 Procedimiento para la preparacion de 4-pirimidilsulfuros.

Country Status (9)

Country Link
US (1) US4224327A (es)
JP (1) JPS54151989A (es)
BE (1) BE873838A (es)
CH (1) CH634068A5 (es)
DE (1) DE2901629A1 (es)
ES (1) ES477355A1 (es)
FR (1) FR2416228A1 (es)
GB (1) GB2014560B (es)
IT (1) IT1092343B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3216843C2 (de) * 1982-05-05 1986-10-23 Ludwig Heumann & Co GmbH, 8500 Nürnberg 3-Thiomethyl-pyridin-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
DE3369514D1 (en) * 1983-05-05 1987-03-05 Heumann Ludwig & Co Gmbh Pyrimidinethioalkyl pyridine derivatives, process for their preparation and medicines containing these compounds
GR82004B (es) * 1983-06-30 1984-12-12 American Home Prod
GB9806739D0 (en) * 1998-03-28 1998-05-27 Univ Newcastle Ventures Ltd Cyclin dependent kinase inhibitors

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4117131A (en) * 1976-12-07 1978-09-26 Warner-Lambert Company Method of inhibiting gastric acid secretions with 2-(4-pyrimidinyl)thioacetamides

Also Published As

Publication number Publication date
DE2901629A1 (de) 1979-08-09
GB2014560A (en) 1979-08-30
US4224327A (en) 1980-09-23
GB2014560B (en) 1982-06-03
FR2416228B1 (es) 1981-09-11
CH634068A5 (it) 1983-01-14
IT1092343B (it) 1985-07-06
BE873838A (fr) 1979-05-16
IT7819905A0 (it) 1978-02-02
JPS54151989A (en) 1979-11-29
FR2416228A1 (fr) 1979-08-31

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