ES469353A1 - Benzimidazole derivative - Google Patents
Benzimidazole derivativeInfo
- Publication number
- ES469353A1 ES469353A1 ES469353A ES469353A ES469353A1 ES 469353 A1 ES469353 A1 ES 469353A1 ES 469353 A ES469353 A ES 469353A ES 469353 A ES469353 A ES 469353A ES 469353 A1 ES469353 A1 ES 469353A1
- Authority
- ES
- Spain
- Prior art keywords
- butylamino
- alkyl
- cycloalkyl
- formula
- new
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
- C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
- C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/26—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/28—Sulfur atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Benzimidazoles of formula (I) and their acid-addition salts are new:- In the formula, R' is H, alkyl or cycloalkyl R2 is alkyl or cycloalkyl R3 is H, primary or secondary alkyl Y is O or S also new are the tautomeric thiols of (I) when Y is S. 16 Cpds. are specifically claimed 4-(2-hydroxy-3-methylaminopropoxy)-2-benzimidazolinone and 1-t-butylamino-3-(2-mercapto-7-methyl-4-benzimidazolyloxy)-2-prop- anol. (I) are beta-blockers with low intrinsic stimulating activity for treating cardiovascular disorders, also having antihypertensive activity. Daily adult dose 5-100 mg. A typical cpd., 4-(3-t-butylamino-2-hydroxypropoxy)-2-benzimidazolinone hydrochloride, was prepd. in 56.3% yield by hydrogenation of 1-t-butylamino-3-(2,3-dinitrophenoxy)-2-propanol and treating the diamino prod. with phosgene.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB18438/77A GB1595316A (en) | 1977-05-03 | 1977-05-03 | 4-(3-amino-2-hydroxy-propoxy)-benzimidazole derivatives and pharmaceutical compositions containing them |
GB4915677 | 1977-11-25 | ||
GB220878 | 1978-01-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES469353A1 true ES469353A1 (en) | 1980-01-01 |
Family
ID=27254036
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES469353A Expired ES469353A1 (en) | 1977-05-03 | 1978-05-02 | Benzimidazole derivative |
Country Status (18)
Country | Link |
---|---|
JP (1) | JPS53135979A (en) |
AR (2) | AR220335A1 (en) |
AU (1) | AU3569678A (en) |
DE (1) | DE2819458A1 (en) |
DK (1) | DK190378A (en) |
ES (1) | ES469353A1 (en) |
FI (1) | FI781349A (en) |
FR (1) | FR2399414A1 (en) |
GR (1) | GR73669B (en) |
IL (1) | IL54591A0 (en) |
IT (1) | IT1096276B (en) |
LU (1) | LU79591A1 (en) |
MC (1) | MC1192A1 (en) |
NL (1) | NL7804794A (en) |
NO (1) | NO781556L (en) |
NZ (1) | NZ187066A (en) |
PT (1) | PT67980A (en) |
SE (1) | SE7805140L (en) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2801980A1 (en) | 1978-01-18 | 1979-07-19 | Boehringer Mannheim Gmbh | 4-HYDROXY-2-BENZIMIDAZOLINE-THIONE DERIVATIVES, THE PROCESS FOR THEIR MANUFACTURING AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS |
EP0003758A1 (en) * | 1978-02-09 | 1979-09-05 | Ciba-Geigy Ag | Etherified hydroxy-benzodiheterocycles and their acid addition salts, process for their preparation and pharmaceutical compositions containing them |
DE2905877A1 (en) * | 1979-02-16 | 1980-08-28 | Boehringer Mannheim Gmbh | NEW AMINOPROPANOL DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS |
CH661501A5 (en) * | 1982-01-26 | 1987-07-31 | Oreal | COMPOUNDS DERIVATIVE FROM AMINO-3 PROPANOL-2 FOR USE IN DYEING HAIR, PREPARATION METHOD THEREOF, DYE COMPOSITION CONTAINING THE SAME, AND HAIR DYEING METHOD THEREOF. |
DE3839743A1 (en) * | 1988-11-25 | 1990-05-31 | Hoechst Ag | METHOD FOR PRODUCING BENZIMIDAZOLONES |
WO2014108449A1 (en) | 2013-01-08 | 2014-07-17 | Atrogi Ab | A screening method, a kit, a method of treatment and a compound for use in a method of treatment |
GB201714740D0 (en) | 2017-09-13 | 2017-10-25 | Atrogi Ab | New compounds and uses |
GB201714745D0 (en) | 2017-09-13 | 2017-10-25 | Atrogi Ab | New compounds and uses |
GB201714734D0 (en) | 2017-09-13 | 2017-10-25 | Atrogi Ab | New compounds and uses |
GB201714736D0 (en) | 2017-09-13 | 2017-10-25 | Atrogi Ab | New compounds and uses |
GB202205895D0 (en) | 2022-04-22 | 2022-06-08 | Atrogi Ab | New medical uses |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1058822A (en) * | 1963-07-30 | 1967-02-15 | Ici Ltd | 3-amino-2-hydroxypropoxy heterocyclic derivatives |
CH559729A5 (en) * | 1970-10-23 | 1975-03-14 | Hoechst Ag | |
US4081447A (en) * | 1975-04-09 | 1978-03-28 | Abbott Laboratories | 5-[2-Hydroxy-3-(3,4-dimethoxy phenethylamino)]-propoxy-3,4-dihydro carbostyril and pharmaceutically acceptable salts thereof |
CH624395A5 (en) * | 1976-01-08 | 1981-07-31 | Ciba Geigy Ag |
-
1978
- 1978-04-26 NZ NZ187066A patent/NZ187066A/en unknown
- 1978-04-27 IL IL54591A patent/IL54591A0/en unknown
- 1978-04-27 FR FR7812492A patent/FR2399414A1/en active Pending
- 1978-05-02 FI FI781349A patent/FI781349A/en not_active Application Discontinuation
- 1978-05-02 JP JP5241778A patent/JPS53135979A/en active Pending
- 1978-05-02 MC MC781299A patent/MC1192A1/en unknown
- 1978-05-02 DK DK190378A patent/DK190378A/en not_active Application Discontinuation
- 1978-05-02 PT PT67980A patent/PT67980A/en unknown
- 1978-05-02 ES ES469353A patent/ES469353A1/en not_active Expired
- 1978-05-02 NO NO781556A patent/NO781556L/en unknown
- 1978-05-03 LU LU79591A patent/LU79591A1/en unknown
- 1978-05-03 SE SE7805140A patent/SE7805140L/en unknown
- 1978-05-03 IT IT23000/78A patent/IT1096276B/en active
- 1978-05-03 AU AU35696/78A patent/AU3569678A/en active Pending
- 1978-05-03 DE DE19782819458 patent/DE2819458A1/en not_active Withdrawn
- 1978-05-03 NL NL7804794A patent/NL7804794A/en not_active Application Discontinuation
- 1978-05-31 AR AR272019A patent/AR220335A1/en active
-
1979
- 1979-01-24 GR GR56130A patent/GR73669B/el unknown
- 1979-07-06 AR AR277226A patent/AR219173A1/en active
Also Published As
Publication number | Publication date |
---|---|
AU3569678A (en) | 1979-11-08 |
SE7805140L (en) | 1978-11-04 |
LU79591A1 (en) | 1979-06-13 |
PT67980B (en) | 1980-05-05 |
IL54591A0 (en) | 1978-07-31 |
JPS53135979A (en) | 1978-11-28 |
FI781349A (en) | 1978-11-04 |
DK190378A (en) | 1978-11-04 |
FR2399414A1 (en) | 1979-03-02 |
AR220335A1 (en) | 1980-10-31 |
IT7823000A0 (en) | 1978-05-03 |
NL7804794A (en) | 1978-11-07 |
GR73669B (en) | 1984-03-28 |
AR219173A1 (en) | 1980-07-31 |
DE2819458A1 (en) | 1978-11-16 |
MC1192A1 (en) | 1979-02-23 |
PT67980A (en) | 1978-06-01 |
NZ187066A (en) | 1981-02-11 |
IT1096276B (en) | 1985-08-26 |
NO781556L (en) | 1978-11-06 |
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