ES469060A1 - Procedimiento para la preparacion de nuevos derivados tio- prenilicos con actividad farmacologica - Google Patents

Procedimiento para la preparacion de nuevos derivados tio- prenilicos con actividad farmacologica

Info

Publication number
ES469060A1
ES469060A1 ES469060A ES469060A ES469060A1 ES 469060 A1 ES469060 A1 ES 469060A1 ES 469060 A ES469060 A ES 469060A ES 469060 A ES469060 A ES 469060A ES 469060 A1 ES469060 A1 ES 469060A1
Authority
ES
Spain
Prior art keywords
butenyl
cysteine
methyl
expectorant
dragees
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES469060A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Investigacion Tecnica y Aplicada SA
Original Assignee
Investigacion Tecnica y Aplicada SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Investigacion Tecnica y Aplicada SA filed Critical Investigacion Tecnica y Aplicada SA
Priority to ES469060A priority Critical patent/ES469060A1/es
Publication of ES469060A1 publication Critical patent/ES469060A1/es
Priority to GB7912686A priority patent/GB2019389B/en
Priority to IT67786/79A priority patent/IT1119070B/it
Priority to US06/031,612 priority patent/US4243679A/en
Priority to FR7910579A priority patent/FR2423484A1/fr
Priority to DE19792916118 priority patent/DE2916118A1/de
Priority to BE2/57742A priority patent/BE875717A/xx
Priority to JP54049625A priority patent/JPS60346B2/ja
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
    • C07C323/59—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton with acylated amino groups bound to the carbon skeleton

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE NUEVOS DERIVADOS TIOPRENILICOS CON ACTIVIDAD FARMACOLOGICA. LA FORMULA GENERAL DE ESTOS COMPUESTOS ES: **FORMULA** DONDE R PUEDE SER UN RADIAL ALIFATICO, AROMATICO, O HETEROCICLICO, SUBSTITUIDO O NO. SE HACE REACCIONAR UN HALURO DE PRENILO CON UN COMPUESTO POSEEDOR DE GRUPOS MERCAPTO. LA REACCION SE REALIZA AÑADIENDO LENTAMENTE EL COMPUESTO PRIMERO EN MEDIO HIDROALCOHOLICO DE PH BASICO Y AGITANDO. DESPUES DE LA ADICION SE SIGUE AGITANDO DURANTE VARIAS HORAS, CON LO QUE TERMINA EL PROCESO. COMO COMPUESTO POSEEDOR DE GRUPOS MERCAPTO SE PUEDE UTILIZAR POR EJEMPLO CISTEINA O MERCAPTOBENZOTIAZOL. EL PRODUCTO OBTENIDO PRESENTA ACTIVIDAD COMO MUCOLITICO.
ES469060A 1978-04-22 1978-04-22 Procedimiento para la preparacion de nuevos derivados tio- prenilicos con actividad farmacologica Expired ES469060A1 (es)

Priority Applications (8)

Application Number Priority Date Filing Date Title
ES469060A ES469060A1 (es) 1978-04-22 1978-04-22 Procedimiento para la preparacion de nuevos derivados tio- prenilicos con actividad farmacologica
GB7912686A GB2019389B (en) 1978-04-22 1979-04-11 S-(substituted) cysteine
IT67786/79A IT1119070B (it) 1978-04-22 1979-04-13 S(3metil 2 butenil)cisteina
US06/031,612 US4243679A (en) 1978-04-22 1979-04-19 S-(3-Methyl-2-butenyl)cysteine
FR7910579A FR2423484A1 (fr) 1978-04-22 1979-04-19 Nouveau compose thioprenylique a activite pharmacologique, son procede de preparation et les compositions pharmaceutiques le contenant
DE19792916118 DE2916118A1 (de) 1978-04-22 1979-04-20 S-(3-methyl-2-butenyl)-cystein, verfahren zu seiner herstellung und arzneimittel
BE2/57742A BE875717A (fr) 1978-04-22 1979-04-20 S-(3-methyl-2-butenyl)cysteine
JP54049625A JPS60346B2 (ja) 1978-04-22 1979-04-21 Ｓ−（３−メチル−２−ブテニル）システインならびにその製法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES469060A ES469060A1 (es) 1978-04-22 1978-04-22 Procedimiento para la preparacion de nuevos derivados tio- prenilicos con actividad farmacologica

Publications (1)

Publication Number Publication Date
ES469060A1 true ES469060A1 (es) 1979-04-01

Family

ID=8475906

Family Applications (1)

Application Number Title Priority Date Filing Date
ES469060A Expired ES469060A1 (es) 1978-04-22 1978-04-22 Procedimiento para la preparacion de nuevos derivados tio- prenilicos con actividad farmacologica

Country Status (8)

Country Link
US (1) US4243679A (es)
JP (1) JPS60346B2 (es)
BE (1) BE875717A (es)
DE (1) DE2916118A1 (es)
ES (1) ES469060A1 (es)
FR (1) FR2423484A1 (es)
GB (1) GB2019389B (es)
IT (1) IT1119070B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0788352B2 (ja) * 1988-06-16 1995-09-27 エスエス製薬株式会社 ヒドロキシアルキルシステイン誘導体およびこれを含有する去痰剤
AU1607601A (en) * 1999-11-15 2001-05-30 J. Manheimer, Inc. Mint flavor and aroma compositions

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3879560A (en) * 1964-01-29 1975-04-22 Oreal Organic amine-organic acid addition salts
US3950542A (en) * 1967-02-21 1976-04-13 L'oreal Cysteamine derivatives for oral treatment of seborrhea
BE788945A (es) * 1971-09-20 1973-03-19 Oreal
FR2187326B1 (es) * 1972-06-15 1975-10-17 Rech Pharm Scientifiques
FR2187327B1 (es) * 1972-06-15 1975-06-20 Rech Pharm Scientifiques
US3974031A (en) * 1974-05-09 1976-08-10 Mitsubishi Chemical Industries Ltd. Process for producing L-cysteine or its derivatives

Also Published As

Publication number Publication date
FR2423484A1 (fr) 1979-11-16
IT1119070B (it) 1986-03-03
JPS60346B2 (ja) 1985-01-07
US4243679A (en) 1981-01-06
IT7967786A0 (it) 1979-04-13
DE2916118A1 (de) 1979-10-31
JPS5511565A (en) 1980-01-26
GB2019389A (en) 1979-10-31
BE875717A (fr) 1979-08-16
GB2019389B (en) 1982-07-14

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