ES467376A2 - Procedure for preparing amidoxima derivatives. (Machine-translation by Google Translate, not legally binding) - Google Patents
Procedure for preparing amidoxima derivatives. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES467376A2 ES467376A2 ES467376A ES467376A ES467376A2 ES 467376 A2 ES467376 A2 ES 467376A2 ES 467376 A ES467376 A ES 467376A ES 467376 A ES467376 A ES 467376A ES 467376 A2 ES467376 A2 ES 467376A2
- Authority
- ES
- Spain
- Prior art keywords
- preparing
- translation
- derivatives
- machine
- legally binding
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title 1
- 239000002253 acid Substances 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- WTDHULULXKLSOZ-UHFFFAOYSA-N Hydroxylamine hydrochloride Chemical compound Cl.ON WTDHULULXKLSOZ-UHFFFAOYSA-N 0.000 abstract 2
- SFZULDYEOVSIKM-UHFFFAOYSA-N chembl321317 Chemical class C1=CC(C(=N)NO)=CC=C1C1=CC=C(C=2C=CC(=CC=2)C(=N)NO)O1 SFZULDYEOVSIKM-UHFFFAOYSA-N 0.000 abstract 2
- IOUJSARVAFXOBT-UHFFFAOYSA-N 2-naphthalen-1-yloxypropanenitrile Chemical compound C1=CC=C2C(OC(C)C#N)=CC=CC2=C1 IOUJSARVAFXOBT-UHFFFAOYSA-N 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 150000001340 alkali metals Chemical class 0.000 abstract 1
- 239000012458 free base Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- KLWGWDOTUDKLKT-UHFFFAOYSA-N n'-hydroxy-2-naphthalen-1-yloxypropanimidamide Chemical compound C1=CC=C2C(OC(C)C(\N)=N/O)=CC=CC2=C1 KLWGWDOTUDKLKT-UHFFFAOYSA-N 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 150000007524 organic acids Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/12—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines
- C07C259/14—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines having carbon atoms of hydroxamidine groups bound to hydrogen atoms or to acyclic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Improvements introduced in the object of the main patent no. 433,816, granted on may 25, 1976, by: process for preparing amidoxime derivatives, in particular for preparing optical isomers of amidoxime derivatives, especially () -2- (1- naphthyloxy) -propionamidoxime and its pharmaceutically acceptable acid addition salts and (-) - 2- (1-naphthyloxy) -propionamidoxime and its pharmaceutically acceptable acid addition salts, characterized in that it is reacted () - or (-) - 2- (1-naphthyloxy) -propionitrile, in a suitable medium and in the presence of an alkali metal alcoholate, with hydroxylamine hydrochloride, to obtain the desired isomer in the form of the free base which can be further treated with an organic acid or inorganic to form the corresponding pharmaceutically acceptable acid addition salt. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7706180A FR2382435A2 (en) | 1977-03-03 | 1977-03-03 | NEW AMIDOXIME DERIVATIVES, THEIR PREPARATION PROCESS AND THE THERAPEUTIC COMPOSITIONS CONTAINING THEM |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES467376A2 true ES467376A2 (en) | 1978-10-16 |
Family
ID=9187484
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES467376A Expired ES467376A2 (en) | 1977-03-03 | 1978-02-28 | Procedure for preparing amidoxima derivatives. (Machine-translation by Google Translate, not legally binding) |
Country Status (9)
| Country | Link |
|---|---|
| AR (1) | AR216941A1 (en) |
| CH (1) | CH633771A5 (en) |
| ES (1) | ES467376A2 (en) |
| FR (1) | FR2382435A2 (en) |
| HU (1) | HU178812B (en) |
| IT (1) | IT1109547B (en) |
| MX (1) | MX5014E (en) |
| OA (1) | OA05901A (en) |
| YU (1) | YU40825B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2506764A1 (en) * | 1981-05-26 | 1982-12-03 | Synthelabo | 2-Aryloxy-amidoxime cpds. - useful as antidepressants |
-
1977
- 1977-03-03 FR FR7706180A patent/FR2382435A2/en active Granted
-
1978
- 1978-02-21 YU YU392/78A patent/YU40825B/en unknown
- 1978-02-24 IT IT20551/78A patent/IT1109547B/en active
- 1978-02-28 ES ES467376A patent/ES467376A2/en not_active Expired
- 1978-03-02 AR AR271289A patent/AR216941A1/en active
- 1978-03-02 MX MX786898U patent/MX5014E/en unknown
- 1978-03-03 CH CH235778A patent/CH633771A5/en not_active IP Right Cessation
- 1978-03-03 OA OA56425A patent/OA05901A/en unknown
- 1978-03-03 HU HU78LA930A patent/HU178812B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AR216941A1 (en) | 1980-02-15 |
| IT1109547B (en) | 1985-12-16 |
| HU178812B (en) | 1982-06-28 |
| MX5014E (en) | 1983-02-21 |
| IT7820551A0 (en) | 1978-02-24 |
| OA05901A (en) | 1981-05-31 |
| FR2382435A2 (en) | 1978-09-29 |
| YU40825B (en) | 1986-06-30 |
| YU39278A (en) | 1983-02-28 |
| CH633771A5 (en) | 1982-12-31 |
| FR2382435B2 (en) | 1980-02-08 |
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