ES462933A1 - Novel 100nitroo77oxoo7 hh indolino *7*6*55d e* isoquinoline derivative - Google Patents

Novel 100nitroo77oxoo7 hh indolino *7*6*55d e* isoquinoline derivative

Info

Publication number
ES462933A1
ES462933A1 ES462933A ES462933A ES462933A1 ES 462933 A1 ES462933 A1 ES 462933A1 ES 462933 A ES462933 A ES 462933A ES 462933 A ES462933 A ES 462933A ES 462933 A1 ES462933 A1 ES 462933A1
Authority
ES
Spain
Prior art keywords
opt
substd
alkyl
indolizino
bond
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES462933A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rhone Poulenc Industries SA
Original Assignee
Rhone Poulenc Industries SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Industries SA filed Critical Rhone Poulenc Industries SA
Publication of ES462933A1 publication Critical patent/ES462933A1/en
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D217/00Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Indolizino-isoquinolines of formula (I) and their acid addn., metal, and N-base addn. salts are new. In (I) R1 = H and R2 = H, amino or alkyl, opt. branched and opt. substd. on the final C by vinyl, ethynyl, COOH alkoxycarbonyl, CN, dialkoxymethyl, hydroxymethyl, dialkylaminoethyl (the 2 alkyls may complete an opt. N-methylated 5-6 membered satd. heterocycle opt. contg. an additional N, O or S atom) or trialkylammoniomethyl or R2 is linear alkyl substd. on the final C by aminomethyl. In these cases R3+R4 form a bond. Alternatively, R1 + R4 = bond and R3 + R2 = CH2.CH(OR5)-. R5O=alkoxy substd. on the C atm alpha to R3-substd. N all alkyl gps. and fragments contain 1-4C. (I) are antimicrobials and antifungals useful as local antiseptics. They are exceptionally low toxicity e.g. acute oral toxicity in mice is >0.75 g/kg. In an example 4-(2-hydroxyethylamino)-10-nitro-7-oxo-7H-indolizino 7,6,5-de isoquinoline was prepd. by reacting the corresp. 4-ethoxy cpd. with ethanolamine.
ES462933A 1976-06-16 1977-10-05 Novel 100nitroo77oxoo7 hh indolino *7*6*55d e* isoquinoline derivative Expired ES462933A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7618232A FR2354770A1 (en) 1976-06-16 1976-06-16 Antimicrobial and antifungal indolizino-isoquinoline cpds. - with (10)-nitro and (7)-oxo substits., useful as local antiseptics

Publications (1)

Publication Number Publication Date
ES462933A1 true ES462933A1 (en) 1978-06-01

Family

ID=9174456

Family Applications (1)

Application Number Title Priority Date Filing Date
ES462933A Expired ES462933A1 (en) 1976-06-16 1977-10-05 Novel 100nitroo77oxoo7 hh indolino *7*6*55d e* isoquinoline derivative

Country Status (4)

Country Link
JP (1) JPS537700A (en)
ES (1) ES462933A1 (en)
FR (1) FR2354770A1 (en)
ZA (1) ZA773568B (en)

Also Published As

Publication number Publication date
FR2354770A1 (en) 1978-01-13
ZA773568B (en) 1978-05-30
JPS537700A (en) 1978-01-24
FR2354770B1 (en) 1979-03-23

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