ES462933A1 - Novel 100nitroo77oxoo7 hh indolino *7*6*55d e* isoquinoline derivative - Google Patents
Novel 100nitroo77oxoo7 hh indolino *7*6*55d e* isoquinoline derivativeInfo
- Publication number
- ES462933A1 ES462933A1 ES462933A ES462933A ES462933A1 ES 462933 A1 ES462933 A1 ES 462933A1 ES 462933 A ES462933 A ES 462933A ES 462933 A ES462933 A ES 462933A ES 462933 A1 ES462933 A1 ES 462933A1
- Authority
- ES
- Spain
- Prior art keywords
- opt
- substd
- alkyl
- indolizino
- bond
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Indolizino-isoquinolines of formula (I) and their acid addn., metal, and N-base addn. salts are new. In (I) R1 = H and R2 = H, amino or alkyl, opt. branched and opt. substd. on the final C by vinyl, ethynyl, COOH alkoxycarbonyl, CN, dialkoxymethyl, hydroxymethyl, dialkylaminoethyl (the 2 alkyls may complete an opt. N-methylated 5-6 membered satd. heterocycle opt. contg. an additional N, O or S atom) or trialkylammoniomethyl or R2 is linear alkyl substd. on the final C by aminomethyl. In these cases R3+R4 form a bond. Alternatively, R1 + R4 = bond and R3 + R2 = CH2.CH(OR5)-. R5O=alkoxy substd. on the C atm alpha to R3-substd. N all alkyl gps. and fragments contain 1-4C. (I) are antimicrobials and antifungals useful as local antiseptics. They are exceptionally low toxicity e.g. acute oral toxicity in mice is >0.75 g/kg. In an example 4-(2-hydroxyethylamino)-10-nitro-7-oxo-7H-indolizino 7,6,5-de isoquinoline was prepd. by reacting the corresp. 4-ethoxy cpd. with ethanolamine.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7618232A FR2354770A1 (en) | 1976-06-16 | 1976-06-16 | Antimicrobial and antifungal indolizino-isoquinoline cpds. - with (10)-nitro and (7)-oxo substits., useful as local antiseptics |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES462933A1 true ES462933A1 (en) | 1978-06-01 |
Family
ID=9174456
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES462933A Expired ES462933A1 (en) | 1976-06-16 | 1977-10-05 | Novel 100nitroo77oxoo7 hh indolino *7*6*55d e* isoquinoline derivative |
Country Status (4)
| Country | Link |
|---|---|
| JP (1) | JPS537700A (en) |
| ES (1) | ES462933A1 (en) |
| FR (1) | FR2354770A1 (en) |
| ZA (1) | ZA773568B (en) |
-
1976
- 1976-06-16 FR FR7618232A patent/FR2354770A1/en active Granted
-
1977
- 1977-06-14 ZA ZA00773568A patent/ZA773568B/en unknown
- 1977-06-14 JP JP7041777A patent/JPS537700A/en active Pending
- 1977-10-05 ES ES462933A patent/ES462933A1/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| FR2354770A1 (en) | 1978-01-13 |
| ZA773568B (en) | 1978-05-30 |
| JPS537700A (en) | 1978-01-24 |
| FR2354770B1 (en) | 1979-03-23 |
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