ES457482A1 - Method of recovering immunoglobulin using a polyol and an alkanoic acid - Google Patents

Method of recovering immunoglobulin using a polyol and an alkanoic acid

Info

Publication number
ES457482A1
ES457482A1 ES457482A ES457482A ES457482A1 ES 457482 A1 ES457482 A1 ES 457482A1 ES 457482 A ES457482 A ES 457482A ES 457482 A ES457482 A ES 457482A ES 457482 A1 ES457482 A1 ES 457482A1
Authority
ES
Spain
Prior art keywords
polyol
alkanoic acid
immunoglobulin
recovering immunoglobulin
recovering
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES457482A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nordisk Insulinlaboratorium
Original Assignee
Nordisk Insulinlaboratorium
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nordisk Insulinlaboratorium filed Critical Nordisk Insulinlaboratorium
Publication of ES457482A1 publication Critical patent/ES457482A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation

Abstract

The process for obtaining immunoglobulin from blood plasma or serum by precipitation with a polycondensed diol or polyol is carried out in the presence of a C4-C12-mono- or -polyalkanoic acid caprylic acid is preferably used, and the process is preferably carried out at a pH of from 4.5 to 5.5. This increases the purity of the product and the yield.
ES457482A 1976-04-06 1977-04-02 Method of recovering immunoglobulin using a polyol and an alkanoic acid Expired ES457482A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK162876AA DK139056B (en) 1976-04-06 1976-04-06 Method for recovering immunoglobulin suitable for intravenous administration.

Publications (1)

Publication Number Publication Date
ES457482A1 true ES457482A1 (en) 1978-03-16

Family

ID=8106680

Family Applications (1)

Application Number Title Priority Date Filing Date
ES457482A Expired ES457482A1 (en) 1976-04-06 1977-04-02 Method of recovering immunoglobulin using a polyol and an alkanoic acid

Country Status (20)

Country Link
US (1) USRE31268E (en)
JP (1) JPS52122620A (en)
AR (1) AR211890A1 (en)
AU (1) AU511474B2 (en)
BE (1) BE852995A (en)
CA (1) CA1072444A (en)
CH (1) CH628813A5 (en)
DD (1) DD129451A5 (en)
DE (1) DE2713817A1 (en)
DK (1) DK139056B (en)
ES (1) ES457482A1 (en)
FI (1) FI61191C (en)
FR (1) FR2347379A1 (en)
GB (1) GB1551865A (en)
HU (1) HU175511B (en)
IL (1) IL51782A (en)
IT (1) IT1075148B (en)
NL (1) NL7703572A (en)
NO (1) NO146763C (en)
SE (1) SE7703843L (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5625114A (en) * 1979-08-07 1981-03-10 Green Cross Corp:The Preparation of human gamma globulin
US4590002A (en) * 1984-12-10 1986-05-20 Ortho Diagnostic Systems, Inc. Methods for preparation of highly purified, gamma globulins free of hepatitis-B-virus infectivity
FR2578425B1 (en) * 1985-03-07 1988-06-10 Nal Transfusion Sanguine Centr IMMUNOGLOBULIN PREPARATIONS HAVING HIGH TITLES OF ANTI-ALLERGENIC BLOCKING ANTIBODIES, THEIR PREPARATION AND THEIR APPLICATIONS FOR THE TREATMENT OF ALLERGIES
FR2632308B1 (en) * 1988-06-07 1991-08-16 Fondation Nale Transfusion San PROCESS AND PLANT FOR THE CONTINUOUS FRACTIONATION OF ANIMAL OR HUMAN PLANT PROTEINS
CA1308023C (en) * 1988-07-29 1992-09-29 William Austin James Mcauley Immunoglobulin extraction utilizing properties of colloidal solutions
US5525519A (en) * 1992-01-07 1996-06-11 Middlesex Sciences, Inc. Method for isolating biomolecules from a biological sample with linear polymers
US5367054A (en) * 1993-04-12 1994-11-22 Stolle Research & Development Corp. Large-scale purification of egg immunoglobulin
EP1786827A4 (en) * 2004-05-14 2008-10-29 Kirin Holdings Kk Methods for immunoglobulin purification
US20060226086A1 (en) * 2005-04-08 2006-10-12 Robinson Thomas C Centrifuge for blood processing systems
EP2078039B1 (en) * 2006-11-01 2017-09-13 Biogen MA Inc. Method of isolating biomacromolecules using low ph and divalent cations
AU2009236653B2 (en) * 2008-04-16 2014-09-25 Biogen Ma Inc. Method of isolating biomacromolecules using polyalkylene glycol and transition metals

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3100737A (en) * 1958-02-05 1963-08-13 Auerswald Wilhelm Method of preparing a plasma protein solution free of active hepatitis virus and product produced thereby
NL286954A (en) * 1962-01-03
NL6702923A (en) * 1966-04-06 1967-10-09
US3916026A (en) * 1968-09-19 1975-10-28 Biotest Serum Institut Gmbh Method for the preparation of gamma-globulin suitable for intravenous use
US3869436A (en) * 1971-06-01 1975-03-04 Statens Bakteriologiska Lab Method for fractionating plasma proteins using peg and ion-exchangers
US3770631A (en) * 1971-06-29 1973-11-06 Baxter Laboratories Inc Clarification of blood serum and plasma
JPS5620287B2 (en) * 1972-06-19 1981-05-13
US3880989A (en) * 1973-01-30 1975-04-29 Baxter Laboratories Inc Production of antisera comprising fractionating plasma or serum with an ethylene oxide-polyoxypropylene block copolymer
US3808189A (en) * 1973-03-15 1974-04-30 American Cyanamid Co Isolation of gamma globulin preparations enriched in iga and igm using polyethylene glycol
JPS5417002B2 (en) * 1974-02-18 1979-06-27
CA1064396A (en) * 1975-02-18 1979-10-16 Myer L. Coval Fractional precipitation of gamma globulin with polyethylene glycol
DE2527064C3 (en) * 1975-06-18 1979-11-15 Biotest-Serum-Institut Gmbh, 6000 Frankfurt Process for the production of an intravenous native human immunoglobulin preparation with a natural half-life and unchanged antibody activity compared to the starting material
US4021540A (en) * 1975-07-28 1977-05-03 Ortho Diagnostics Inc. Preparation of a hepatitis B immune globulin and use thereof as a prophylactic material
JPS5234918A (en) * 1975-09-06 1977-03-17 Biotest Serum Institut Gmbh Production of gmmaglobulin suitable for dosing into vein
US4075193A (en) * 1976-11-26 1978-02-21 Parke, Davis & Company Process for producing intravenous immune globulin
US4124576A (en) * 1976-12-03 1978-11-07 Coval M L Method of producing intravenously injectable gamma globulin

Also Published As

Publication number Publication date
AU2391077A (en) 1978-10-12
FI771071A (en) 1977-10-07
IT1075148B (en) 1985-04-22
NO771225L (en) 1977-10-07
BE852995A (en) 1977-07-18
NL7703572A (en) 1977-10-10
AU511474B2 (en) 1980-08-21
CH628813A5 (en) 1982-03-31
FI61191B (en) 1982-02-26
FI61191C (en) 1982-06-10
GB1551865A (en) 1979-09-05
DK139056B (en) 1978-12-11
NO146763B (en) 1982-08-30
FR2347379B1 (en) 1981-11-20
IL51782A (en) 1980-12-31
NO146763C (en) 1982-12-08
IL51782A0 (en) 1977-05-31
DK162876A (en) 1977-10-07
FR2347379A1 (en) 1977-11-04
DK139056C (en) 1979-05-21
HU175511B (en) 1980-08-28
SE7703843L (en) 1977-10-07
USRE31268E (en) 1983-06-07
JPS52122620A (en) 1977-10-15
CA1072444A (en) 1980-02-26
AR211890A1 (en) 1978-03-31
DD129451A5 (en) 1978-01-18
DE2713817A1 (en) 1977-10-27

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