ES450204A1 - A procedure for the preparation of new derivatives of imidazole. (Machine-translation by Google Translate, not legally binding) - Google Patents
A procedure for the preparation of new derivatives of imidazole. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES450204A1 ES450204A1 ES450204A ES450204A ES450204A1 ES 450204 A1 ES450204 A1 ES 450204A1 ES 450204 A ES450204 A ES 450204A ES 450204 A ES450204 A ES 450204A ES 450204 A1 ES450204 A1 ES 450204A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- acid addition
- addition salt
- leaving group
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 3
- 150000002460 imidazoles Chemical class 0.000 title abstract 2
- 239000002253 acid Substances 0.000 abstract 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 4
- 150000003839 salts Chemical class 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- 239000012458 free base Substances 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000000845 anti-microbial effect Effects 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 239000002585 base Substances 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 229940079865 intestinal antiinfectives imidazole derivative Drugs 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 125000003884 phenylalkyl group Chemical group 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 229910052717 sulfur Chemical group 0.000 abstract 1
- 239000011593 sulfur Chemical group 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6503—Five-membered rings
- C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
A procedure for the preparation of new imidazole derivatives of the formula **(See formula)** wherein each of R1 and R2 is independently phenyl, straight-chain lower phenylalkyl, or straight-chain lower phenylalkylene; or one of the foregoing substituted on the phenyl ring by one or more substituents independently selected from the group consisting of lower alkyl of 1 to 4 carbon atoms, halo and trifluoromethyl; X is oxygen or sulfur; n is a number from 1 to 8 with the proviso that n is not 1 when it is phenyl or substituted phenyl; or an acid addition salt of the same antimicrobial, whose procedure consists of: a) reacting a compound of formula: **(See formula)** or an acid addition salt thereof, where R1 and n are as defined above and Y is hydroxyl or a leaving group, with a compound of formula R2-W, where W is -CH.-SH or a leaving group, with the following conditions: (i) when Y represents hydroxyl, V represents a leaving group; and (ii) when Y represents a leaving group, W represents CH or -SH, and R2 is the one previously defined, in the presence of a base to obtain the corresponding compound of formula (I); and (b) optionally converting the free base to its acid addition salt or converting the acid addition salt to the corresponding free base. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US59961875A | 1975-07-28 | 1975-07-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES450204A1 true ES450204A1 (en) | 1977-11-16 |
Family
ID=24400359
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES450204A Expired ES450204A1 (en) | 1975-07-28 | 1976-07-27 | A procedure for the preparation of new derivatives of imidazole. (Machine-translation by Google Translate, not legally binding) |
Country Status (7)
| Country | Link |
|---|---|
| BE (1) | BE844516A (en) |
| DK (1) | DK158943C (en) |
| ES (1) | ES450204A1 (en) |
| FI (1) | FI64584C (en) |
| NO (1) | NO145058C (en) |
| SE (1) | SE422681B (en) |
| ZA (1) | ZA764536B (en) |
-
1976
- 1976-02-20 FI FI760423A patent/FI64584C/en not_active IP Right Cessation
- 1976-02-26 DK DK081276A patent/DK158943C/en not_active IP Right Cessation
- 1976-02-26 SE SE7602509A patent/SE422681B/en not_active IP Right Cessation
- 1976-03-05 NO NO760783A patent/NO145058C/en unknown
- 1976-07-26 BE BE169238A patent/BE844516A/en not_active IP Right Cessation
- 1976-07-27 ES ES450204A patent/ES450204A1/en not_active Expired
- 1976-07-28 ZA ZA00764536A patent/ZA764536B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA764536B (en) | 1978-03-29 |
| DK158943C (en) | 1990-12-31 |
| DK158943B (en) | 1990-08-06 |
| SE7602509L (en) | 1977-01-29 |
| BE844516A (en) | 1977-01-26 |
| FI64584C (en) | 1983-12-12 |
| NO145058B (en) | 1981-09-21 |
| NO760783L (en) | 1977-01-31 |
| FI64584B (en) | 1983-08-31 |
| FI760423A (en) | 1977-01-29 |
| SE422681B (en) | 1982-03-22 |
| NO145058C (en) | 1982-01-04 |
| DK81276A (en) | 1977-01-29 |
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