ES447002A1 - A procedure for the preparation of pyridine derivatives. (Machine-translation by Google Translate, not legally binding) - Google Patents

Abstract

A procedure for the preparation of pyridine derivatives of the formula **(See formula)** and its acid addition salts, in which R1, R2 and R6 are the same or different and represent hydrogen, trifluoromethyl or an alkyl, aralkyl or aryl radical, any of these radicals being able to be substituted by alkyl, alkoxy, nitro or trlfluoromethyl or R1 and R2 taken together represent an alkylene chain -CH2 (CH2) nCH2- where n is 1, 2 or 3 R7 represents hydrogen or the simple or multiple substitution by alkyl, aralkyl or aryl radicals any of whose radicals can be substituted by alkyl, alkoxy, nitro or trifluoromethyl and when R1 and R2 taken together form an alkylene chain the resulting ring can be substituted by one or more R7 radicals as indicated above, m is 1, 2 or 3 r4 is an alkyl radical characterized in that in its implementation it comprises reacting a compound of formula II in an inert organic solvent medium **(See formula)** where R1, R2, R6, R7 and m have the meaning indicated in connection with formula I above and M is sodium, potassium, lithium or MgHal, where Hal is chlorine, bromine or iodine, with an isothiocyanate of the formula R4NCS, where R4 has the same meaning defined in the case of formula I and treating the reaction mass with a hydrogen ion donor, such as water, an alcohol or an acid and isolating the product of formula II. (Machine-translation by Google Translate, not legally binding)