ES444259A1 - Perhalo-alkylamidines - Google Patents

Perhalo-alkylamidines

Info

Publication number
ES444259A1
ES444259A1 ES444259A ES444259A ES444259A1 ES 444259 A1 ES444259 A1 ES 444259A1 ES 444259 A ES444259 A ES 444259A ES 444259 A ES444259 A ES 444259A ES 444259 A1 ES444259 A1 ES 444259A1
Authority
ES
Spain
Prior art keywords
lower alkyl
substituted
nitrogen
group
optionally
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES444259A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of ES444259A1 publication Critical patent/ES444259A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C273/00—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C273/18—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas
    • C07C273/1809—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety
    • C07C273/1818—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety from -N=C=O and XNR'R"
    • C07C273/1827—X being H
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/42—Oxygen atoms attached in position 3 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

A procedure for the preparation of new substituted perhaloalkylamidines of formula: where R is a perhalogenated lower alkyl group; R2 is hydrogen, lower alkyl, or lower alkanoyl; is lower alkyl, lower phenylalkyl, lower alkenyl, lower alkynyl, cycloalkyl or cycloalkenyl, the groups of which are substituted with one or more hydroxy, lower hydroxyalkyl, lower alkoxy, lower alkylthio, lower alkanoyloxy, lower alkanoylamino, phenyl, hydroxyphenyl, lower alkoxyphenyl, phenoxy, phenylsulfinyl, naphthylsuffinyl, cycloalkyl, lower alkylphenyl, lower alkenylphenyl, phenylcycloalkyl, or halogen; R3 is also lower phenylalkyl substituted with perhaloalkylamidino-lower alkyl; R3 may also be a 5- to 7-membered heterocyclic group containing one or two amidine nitrogen-linked heteroatoms through a lower alkyl group selected from oxygen and nitrogen or a benzoheterocyclic group optionally substituted by lower alkyl, lower alkoxy, or benzoyl, where the benzo radical is fused to a 5- to 7-membered heterocyclic ring with one or two heteroatoms selected from oxygen and nitrogen; and where each amino or hydroxy group with a labile proton is optionally converted to a glycoside; and its non-toxic and pharmaceutically acceptable salts; whose procedure consists of: 1) reacting a perhalogenated lower alkylnitrile with an amine of formula: H-NR2R3 where R2 and R3 defined above. 2) Optionally, when R is hydrogen, react the compound obtained in the previous step with an alkylating agent or an acylating agent. (Machine-translation by Google Translate, not legally binding)
ES444259A 1975-01-15 1976-01-13 Perhalo-alkylamidines Expired ES444259A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US54130875A 1975-01-15 1975-01-15
US62973575A 1975-11-10 1975-11-10

Publications (1)

Publication Number Publication Date
ES444259A1 true ES444259A1 (en) 1977-10-01

Family

ID=27066677

Family Applications (1)

Application Number Title Priority Date Filing Date
ES444259A Expired ES444259A1 (en) 1975-01-15 1976-01-13 Perhalo-alkylamidines

Country Status (21)

Country Link
JP (1) JPS51125202A (en)
AR (1) AR213168A1 (en)
AU (1) AU499649B2 (en)
BG (1) BG25074A3 (en)
CS (1) CS189737B2 (en)
DD (1) DD124598A5 (en)
DE (1) DE2601137A1 (en)
DK (1) DK593975A (en)
ES (1) ES444259A1 (en)
FI (1) FI753673A (en)
FR (1) FR2297615A1 (en)
GB (1) GB1490671A (en)
IL (1) IL48784A0 (en)
LU (1) LU74170A1 (en)
NL (1) NL7515256A (en)
NO (1) NO754426L (en)
NZ (1) NZ179730A (en)
PL (1) PL101099B1 (en)
PT (1) PT64673B (en)
SE (1) SE7514776L (en)
SU (1) SU633471A3 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4423246A (en) 1982-02-22 1983-12-27 Olin Corporation Selected trichloroacetamidines
US4709052A (en) * 1983-05-31 1987-11-24 Sumitomo Chemical Company, Limited Soil disease-controlling imides
EP0226511B1 (en) * 1985-12-13 1989-08-02 LABORATOIRE L. LAFON Société anonyme dite: 5-phenyl-1,4,5,6-tetrahydropyrimidine derivatives, preparation process and medicinal use
WO1992004054A1 (en) * 1990-08-30 1992-03-19 STATE OF OREGON, acting by and through THE OREGON STATE BOARD OF HIGHER EDUCATION, acting for and on behalf of THE OREGON HEALTH SCIENCES UNIVERSITY, PORTLAND, OREGON, and THE UNIVERSITY OF OREGON, EUGENE, OREGON, Johnson Hall, University of Oregon Substituted amidines having high binding to the sigma receptor and the use thereof
ES2055651B1 (en) * 1992-07-20 1995-03-01 Vita Invest Sa PROCEDURE FOR THE OBTAINING OF NEW AMIDINES DERIVED FROM 3-AMINOETILINDOLES.
GB9425701D0 (en) * 1994-12-20 1995-02-22 Wellcome Found Enzyme inhibitors
US7423176B2 (en) 2004-04-13 2008-09-09 Cephalon, Inc. Bicyclic aromatic sulfinyl derivatives
EP1586561A1 (en) * 2004-04-13 2005-10-19 Cephalon, Inc. Bicyclic aromatic sulfinyl derivatives
AU2008251476B2 (en) 2007-05-10 2014-06-12 Plastipak Packaging, Inc. Oxygen scavenging molecules, articles containing same, and methods of their use
WO2008144263A1 (en) * 2007-05-18 2008-11-27 The Ohio State University Research Foundation Potent indole-3-carbinol-derived antitumor agents
US8153680B2 (en) 2009-08-25 2012-04-10 The Ohio State University Research Foundation Alkyl indole-3-carbinol-derived antitumor agents
ES2630404T3 (en) 2009-09-29 2017-08-21 Plastipak Packaging, Inc. Compositions of oxygen elimination polymer compatible with dye and articles made therefrom
AU2010319384B2 (en) 2009-11-13 2016-09-15 Plastipak Packaging, Inc. Oxygen scavengers, composition comprising the scavengers, and articles made from the compositions
US9181414B2 (en) 2009-11-13 2015-11-10 Plastipak Packaging, Inc. Oxygen scavengers, compositions comprising the scavengers, and articles made from the compositions
MX2014013181A (en) 2012-04-30 2015-05-14 Plastipak Packaging Inc Oxygen scavenging compositions.
US11338983B2 (en) 2014-08-22 2022-05-24 Plastipak Packaging, Inc. Oxygen scavenging compositions, articles containing same, and methods of their use
US10351692B2 (en) 2014-10-17 2019-07-16 Plastipak Packaging, Inc. Oxygen scavengers, compositions comprising the scavengers, and articles made from the compositions

Also Published As

Publication number Publication date
DD124598A5 (en) 1977-03-02
AU499649B2 (en) 1979-04-26
BG25074A3 (en) 1978-07-12
DK593975A (en) 1976-07-16
JPS51125202A (en) 1976-11-01
DE2601137A1 (en) 1976-07-22
SE7514776L (en) 1976-07-16
NZ179730A (en) 1978-07-10
SU633471A3 (en) 1978-11-15
PT64673B (en) 1978-01-04
GB1490671A (en) 1977-11-02
NO754426L (en) 1976-07-16
LU74170A1 (en) 1976-12-31
CS189737B2 (en) 1979-04-30
IL48784A0 (en) 1976-03-31
PL101099B1 (en) 1978-11-30
FR2297615A1 (en) 1976-08-13
NL7515256A (en) 1976-07-19
PT64673A (en) 1976-02-01
FI753673A (en) 1976-07-16
AR213168A1 (en) 1978-12-29
AU1006076A (en) 1977-07-14

Similar Documents

Publication Publication Date Title
ES444259A1 (en) Perhalo-alkylamidines
NO851227L (en) CARBAPENEEM DERIVATIVES AND PROCEDURES FOR PREPARING THEREOF
ES467288A1 (en) N-(substituted-aminoalkyl)-2-oxo-1-pyrrolidineacetamides
ES459024A1 (en) Tetracyclic derivatives and pharmaceutical compositions of matter
ZA857523B (en) Pharmaceutical compositions containing diazepines and having a paf-antagonistic activity
CA1272482C (en) Quinolinecarboxylic acid derivatives
ES8500244A1 (en) Aryl pyrazinones.
ES8704965A1 (en) 9a-Aza-9a-homoerythromycin derivatives.
ES386409A1 (en) 5-azaspiro(2.4)heptane-4 6-diones
DE3869163D1 (en) BENZYLIDENAMINO, BENZYLAMINO AND BENZOYLAMINO IMIDAZOLE DERIVATIVES.
ES419019A1 (en) Indolo-2,3-c quinolinone derivatives
ES457227A1 (en) Sulfur-containing derivatives of cyclohexylphenyl-ethane
ES417018A1 (en) Phosphorus derivatives of triazolin-5-ones and thiones
ES458729A1 (en) 2,3-Dihydrobenzofurans
ES8801212A1 (en) Isoquinoline derivatives
ES471872A1 (en) Tetrahydro-s-triazine thiones, process for their preparation and acaricidal compositions containing them.
ES400414A1 (en) Procedure for the preparation of N-substituted piperidine derivatives and their use as stabilizers. (Machine-translation by Google Translate, not legally binding)
ES381403A1 (en) Basically substituted 2,4-(1h,3h)-quinazolindione derivatives
ES375525A1 (en) A procedure for the preparation of N-substitute and n, N-disstituted aminocarbonylalkilic compounds. (Machine-translation by Google Translate, not legally binding)
ES375527A1 (en) A procedure for the preparation of aminocarbonylalkilic compounds N-substituted or n, N-disused. (Machine-translation by Google Translate, not legally binding)
ES424500A1 (en) A procedure for the preparation of derivatives of 1-amino (replaced) -2-oxy) -2-propanol. (Machine-translation by Google Translate, not legally binding)
GB1549172A (en) Benzobicyclononene derivatives
ES417269A1 (en) 3-azetidinylethyl-1-phenyl-2-midazolidinone derivatives
ES449570A1 (en) Tetrazolo(a)quinazolone derivatives
ES393186A1 (en) A procedure for preparing quinazoline derivatives. (Machine-translation by Google Translate, not legally binding)