ES442994A1 - Production of 2-chloro-1-2-diethylamino-ethyl-5-o-fluorophenyl- 1,3-dihydro-2h-1,4-benzodiazepin-2-one - Google Patents

Production of 2-chloro-1-2-diethylamino-ethyl-5-o-fluorophenyl- 1,3-dihydro-2h-1,4-benzodiazepin-2-one

Info

Publication number
ES442994A1
ES442994A1 ES442994A ES442994A ES442994A1 ES 442994 A1 ES442994 A1 ES 442994A1 ES 442994 A ES442994 A ES 442994A ES 442994 A ES442994 A ES 442994A ES 442994 A1 ES442994 A1 ES 442994A1
Authority
ES
Spain
Prior art keywords
benzodiazepin
diethylamino
fluorophenyl
chloro
ethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES442994A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Grindstedvaerket AS
Original Assignee
Grindstedvaerket AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Grindstedvaerket AS filed Critical Grindstedvaerket AS
Publication of ES442994A1 publication Critical patent/ES442994A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

A process for obtaining 7-chloro-1- [2- (diethylamino) -ethyl] -5- (o-fluorophenyl) -1,3-dihydro-2H-1,4-benzodiazepin-2-one, comprising a Grignard reaction of 7-chloro-1- [2- (diethylamino) -ethyl] -1,3-dihydro-2H-1,4-benzodiazepin-2-one-4-oxide with o-fluorophenyl-magnesium bromide in situ in the presence of 1,2-dibromoethane, after which 7-chloro-1- [2- (diethylamino) -ethyl] -5- (o-fluorophenyl) -1,3,4 is dehydrated, Resulting 5-tetrahydro-4-hydroxy-2H-1,4-benzodiazepin-2-one. (Machine-translation by Google Translate, not legally binding)
ES442994A 1974-11-29 1975-11-26 Production of 2-chloro-1-2-diethylamino-ethyl-5-o-fluorophenyl- 1,3-dihydro-2h-1,4-benzodiazepin-2-one Expired ES442994A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB5171174A GB1455675A (en) 1974-11-29 1974-11-29 Production of 2-chloro-1-2-diethylamino-ethyl-5-o-fluorophenyl- 1,3-dihydro-2h-1,4-benzodiazepin-2-one

Publications (1)

Publication Number Publication Date
ES442994A1 true ES442994A1 (en) 1977-04-16

Family

ID=10461085

Family Applications (1)

Application Number Title Priority Date Filing Date
ES442994A Expired ES442994A1 (en) 1974-11-29 1975-11-26 Production of 2-chloro-1-2-diethylamino-ethyl-5-o-fluorophenyl- 1,3-dihydro-2h-1,4-benzodiazepin-2-one

Country Status (11)

Country Link
JP (1) JPS5176284A (en)
AT (1) AT350057B (en)
CA (1) CA1044232A (en)
DK (1) DK519775A (en)
ES (1) ES442994A1 (en)
FI (1) FI753334A (en)
GB (1) GB1455675A (en)
NL (1) NL7513754A (en)
NO (1) NO754025L (en)
SE (1) SE7513444L (en)
YU (1) YU298175A (en)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4837038A (en) * 1971-09-14 1973-05-31

Also Published As

Publication number Publication date
GB1455675A (en) 1976-11-17
DK519775A (en) 1976-05-30
SE7513444L (en) 1976-05-31
ATA905775A (en) 1978-10-15
AT350057B (en) 1979-05-10
NL7513754A (en) 1976-06-01
FI753334A (en) 1976-05-30
YU298175A (en) 1982-02-28
CA1044232A (en) 1978-12-12
JPS5176284A (en) 1976-07-01
NO754025L (en) 1976-06-01

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