ES440575A1 - Manufacture of novel propylene-diamine derivative - Google Patents

Manufacture of novel propylene-diamine derivative

Info

Publication number
ES440575A1
ES440575A1 ES440575A ES440575A ES440575A1 ES 440575 A1 ES440575 A1 ES 440575A1 ES 440575 A ES440575 A ES 440575A ES 440575 A ES440575 A ES 440575A ES 440575 A1 ES440575 A1 ES 440575A1
Authority
ES
Spain
Prior art keywords
formula
signify
salts
alkyl
general formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES440575A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chinoin Private Co Ltd
Original Assignee
Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt filed Critical Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt
Publication of ES440575A1 publication Critical patent/ES440575A1/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/27—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by saturated carbon chains
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/35—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/36—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Method for the manufacture of new propylene diamine derivatives, of the general formula **(See formula)** and its salts, in whose formula A and B signify a hydrogen atom, an acyl, alkyl or aralkyl group, R and R1 signify an alkyl, aryl or aralkyl group or R and R1 together form with the carbon atom linked to them a cycloalkyl group, characterized in that the amines of the general formula are reacted **(See formula)** or its salts, or its 1-phenyl-1,2-alkenylamine derivatives, by means of a Friedel-Crafts reaction with benzene, advantageously hot, in whose formula Q stands for a hydroxyl group or a halogen atom R and R have the meaning indicated above, A and B signify a hydrogen atom, an alkyl or aralkyl group and in the compounds thus obtained of the general formula (I) the groups A and/or B are converted to each other and/or the compounds obtained with inorganic or organic acids are converted into the salts thereof. (Machine-translation by Google Translate, not legally binding)
ES440575A 1972-04-24 1975-08-29 Manufacture of novel propylene-diamine derivative Expired ES440575A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HUCI1228A HU164883B (en) 1972-04-24 1972-04-24

Publications (1)

Publication Number Publication Date
ES440575A1 true ES440575A1 (en) 1977-03-01

Family

ID=10994437

Family Applications (2)

Application Number Title Priority Date Filing Date
ES413960A Expired ES413960A1 (en) 1972-04-24 1973-04-21 Manufacture of novel propylene-diamine derivative
ES440575A Expired ES440575A1 (en) 1972-04-24 1975-08-29 Manufacture of novel propylene-diamine derivative

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES413960A Expired ES413960A1 (en) 1972-04-24 1973-04-21 Manufacture of novel propylene-diamine derivative

Country Status (13)

Country Link
JP (2) JPS5842182B2 (en)
AT (1) AT324299B (en)
CH (3) CH594595A5 (en)
CS (1) CS203057B2 (en)
DE (1) DE2320058C2 (en)
ES (2) ES413960A1 (en)
FR (1) FR2183006A1 (en)
HU (1) HU164883B (en)
NL (1) NL7305696A (en)
NO (1) NO137548C (en)
SE (1) SE413022B (en)
SU (4) SU1014468A3 (en)
YU (3) YU110873A (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS51151972A (en) * 1975-06-20 1976-12-27 Matsushita Electric Ind Co Ltd Conveyor means
IT1150959B (en) * 1980-06-10 1986-12-17 Simes DATED SUBSTANCES OF VASAL ANTISPASTIC ACTIVITIES AND PROCEDURES FOR THEIR PREPARATION
IT1156601B (en) * 1982-05-13 1987-02-04 Gd Spa DEVICE FOR THE TRANSFORMATION OF A CONTINUOUS ROTARY MOTOR OF A DRIVING SHAFT INTO AN INTERMITTENT AROTATORY MOTOR OF A DRIVEN SHAFT
JPS60172762A (en) * 1984-02-17 1985-09-06 Kyoei Giken:Kk Cam device
JPH0522497Y2 (en) * 1987-12-12 1993-06-10
US7511077B2 (en) * 2005-02-09 2009-03-31 Neuromed Pharmaceuticals Ltd. Diamine calcium channel blockers

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1768297B1 (en) * 1968-04-26 1971-12-16 Beiersdorf Ag Substituted alkylenediamines and their salts

Also Published As

Publication number Publication date
SU1014468A3 (en) 1983-04-23
CS203057B2 (en) 1981-02-27
SU576040A3 (en) 1977-10-05
DE2320058C2 (en) 1982-11-18
SE413022B (en) 1980-03-31
HU164883B (en) 1974-05-28
JPS4947354A (en) 1974-05-08
YU2080A (en) 1983-02-28
CH597146A5 (en) 1978-03-31
NO137548C (en) 1978-03-15
ES413960A1 (en) 1976-05-01
NO137548B (en) 1977-12-05
FR2183006A1 (en) 1973-12-14
JPS5838237A (en) 1983-03-05
CH594595A5 (en) 1978-01-13
SU564805A3 (en) 1977-07-05
AT324299B (en) 1975-08-25
SU576915A3 (en) 1977-10-15
SE7305485L (en) 1973-10-25
YU110873A (en) 1982-02-28
YU1980A (en) 1983-02-28
JPS5842182B2 (en) 1983-09-17
CH580054A5 (en) 1976-09-30
FR2183006B1 (en) 1976-09-03
NL7305696A (en) 1973-10-26
DE2320058A1 (en) 1973-11-08

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