ES438163A1 - Un metodo para la preparacion de un conjugado de prostaglan-dina. - Google Patents
Un metodo para la preparacion de un conjugado de prostaglan-dina.Info
- Publication number
- ES438163A1 ES438163A1 ES438163A ES438163A ES438163A1 ES 438163 A1 ES438163 A1 ES 438163A1 ES 438163 A ES438163 A ES 438163A ES 438163 A ES438163 A ES 438163A ES 438163 A1 ES438163 A1 ES 438163A1
- Authority
- ES
- Spain
- Prior art keywords
- group
- formula
- prostaglandins
- chosen
- prostaglandin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000003180 prostaglandins Chemical class 0.000 title abstract 6
- 229940094443 oxytocics prostaglandins Drugs 0.000 title abstract 3
- 238000009472 formulation Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 229920002521 macromolecule Polymers 0.000 abstract 3
- RGSFGYAAUTVSQA-UHFFFAOYSA-N Cyclopentane Chemical compound C1CCCC1 RGSFGYAAUTVSQA-UHFFFAOYSA-N 0.000 abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- IBOFVQJTBBUKMU-UHFFFAOYSA-N 4,4'-methylene-bis-(2-chloroaniline) Chemical compound C1=C(Cl)C(N)=CC=C1CC1=CC=C(N)C(Cl)=C1 IBOFVQJTBBUKMU-UHFFFAOYSA-N 0.000 abstract 1
- 230000010933 acylation Effects 0.000 abstract 1
- 238000005917 acylation reaction Methods 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 238000009833 condensation Methods 0.000 abstract 1
- 230000005494 condensation Effects 0.000 abstract 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
- 125000002433 cyclopentenyl group Chemical group C1(=CCCC1)* 0.000 abstract 1
- DMEGYFMYUHOHGS-UHFFFAOYSA-N heptamethylene Natural products C1CCCCCC1 DMEGYFMYUHOHGS-UHFFFAOYSA-N 0.000 abstract 1
- 230000002163 immunogen Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6883—Polymer-drug antibody conjugates, e.g. mitomycin-dextran-Ab; DNA-polylysine-antibody complex or conjugate used for therapy
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01F—COMPOUNDS OF THE METALS BERYLLIUM, MAGNESIUM, ALUMINIUM, CALCIUM, STRONTIUM, BARIUM, RADIUM, THORIUM, OR OF THE RARE-EARTH METALS
- C01F11/00—Compounds of calcium, strontium, or barium
- C01F11/46—Sulfates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6081—Albumin; Keyhole limpet haemocyanin [KLH]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Geology (AREA)
- Inorganic Chemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB24660/74A GB1516642A (en) | 1974-06-04 | 1974-06-04 | Biological reagent |
| GB5398674 | 1974-12-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES438163A1 true ES438163A1 (es) | 1977-05-16 |
Family
ID=26257224
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES438163A Expired ES438163A1 (es) | 1974-06-04 | 1975-06-03 | Un metodo para la preparacion de un conjugado de prostaglan-dina. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US4110432A (en:Method) |
| JP (1) | JPS519714A (en:Method) |
| AU (1) | AU8180175A (en:Method) |
| CH (1) | CH614221A5 (en:Method) |
| DE (1) | DE2524637A1 (en:Method) |
| DK (1) | DK248775A (en:Method) |
| ES (1) | ES438163A1 (en:Method) |
| FI (1) | FI751633A7 (en:Method) |
| FR (1) | FR2273554A1 (en:Method) |
| IL (1) | IL47412A0 (en:Method) |
| NL (1) | NL7506560A (en:Method) |
| SE (1) | SE7506313L (en:Method) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4678671A (en) * | 1981-12-15 | 1987-07-07 | Cordis Europa N.V. | Conjugates of anticoagulant and protein |
| NL188622C (nl) * | 1981-12-15 | 1992-08-17 | Cordis Europ | Werkwijze ter verbetering van de bloedcompatibiliteit van een materiaaloppervlak door bekleding daarvan met een heparine of heparine-analoga en een eiwit houdende film, alsmede voorwerp, omvattende een oppervlak met verbeterde bloedcompatibiliteit verkregen onder toepassing van een op het oppervlak aangebrachte heparine of heparine-analoga en een eiwit houdende film. |
| US4749570A (en) * | 1981-12-31 | 1988-06-07 | The Governors Of The University Of Alberta | Targeting conjugates of albumin and therapeutic agents |
| US4663160A (en) * | 1983-03-14 | 1987-05-05 | Miles Laboratories, Inc. | Vaccines for gram-negative bacteria |
| EP0172962A1 (en) * | 1984-08-30 | 1986-03-05 | Ono Pharmaceutical Co., Ltd. | Prostaglandins |
| DE68919366T2 (de) * | 1988-09-30 | 1995-05-18 | Neorx Corp | Spaltbare linker zur reduzierung der akkumulierung von immunokonjugaten in nicht-zielorganen. |
| US5171563A (en) * | 1988-09-30 | 1992-12-15 | Neorx Corporation | Cleavable linkers for the reduction of non-target organ retention of immunoconjugates |
| US6007817A (en) | 1988-10-11 | 1999-12-28 | University Of Southern California | Vasopermeability enhancing immunoconjugates |
| EP0540670B1 (en) * | 1990-07-26 | 1996-03-20 | Monsanto Company | Method for preparation of crosslinked polyamines |
| US8333996B2 (en) * | 1995-05-19 | 2012-12-18 | Etex Corporation | Calcium phosphate delivery vehicle and adjuvant |
| US8728536B2 (en) * | 1996-10-16 | 2014-05-20 | Etex Corporation | Chemotherapeutic composition using nanocrystalline calcium phosphate paste |
| EP3254710B1 (en) * | 2003-04-11 | 2019-05-22 | Etex Corporation | Osteoinductive bone material |
| KR101218454B1 (ko) * | 2004-04-15 | 2013-01-04 | 에텍스 코포레이션 | 세팅 지연 칼슘 포스페이트 페이스트 |
| US8147860B2 (en) | 2005-12-06 | 2012-04-03 | Etex Corporation | Porous calcium phosphate bone material |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3690834A (en) * | 1971-01-11 | 1972-09-12 | Syva Co | Ligand determination with spin labeled compounds by receptor displacement |
| US3935074A (en) * | 1973-12-17 | 1976-01-27 | Syva Company | Antibody steric hindrance immunoassay with two antibodies |
-
1975
- 1975-06-03 ES ES438163A patent/ES438163A1/es not_active Expired
- 1975-06-03 JP JP50066961A patent/JPS519714A/ja active Pending
- 1975-06-03 IL IL47412A patent/IL47412A0/xx unknown
- 1975-06-03 DK DK248775A patent/DK248775A/da unknown
- 1975-06-03 AU AU81801/75A patent/AU8180175A/en not_active Expired
- 1975-06-03 US US05/583,458 patent/US4110432A/en not_active Expired - Lifetime
- 1975-06-03 NL NL7506560A patent/NL7506560A/xx not_active Application Discontinuation
- 1975-06-03 DE DE19752524637 patent/DE2524637A1/de not_active Withdrawn
- 1975-06-03 FI FI751633A patent/FI751633A7/fi not_active Application Discontinuation
- 1975-06-03 CH CH713175A patent/CH614221A5/xx not_active IP Right Cessation
- 1975-06-03 FR FR7517238A patent/FR2273554A1/fr active Granted
- 1975-06-03 SE SE7506313A patent/SE7506313L/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NL7506560A (nl) | 1975-12-08 |
| US4110432A (en) | 1978-08-29 |
| FI751633A7 (en:Method) | 1975-12-05 |
| SE7506313L (sv) | 1975-12-05 |
| DE2524637A1 (de) | 1976-01-02 |
| DK248775A (da) | 1975-12-05 |
| IL47412A0 (en) | 1975-08-31 |
| CH614221A5 (en:Method) | 1979-11-15 |
| FR2273554B1 (en:Method) | 1978-07-28 |
| AU8180175A (en) | 1976-12-09 |
| JPS519714A (en:Method) | 1976-01-26 |
| FR2273554A1 (fr) | 1976-01-02 |
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