ES436458A1 - Process for the preparation of digoxin derivatives - Google Patents

Process for the preparation of digoxin derivatives

Info

Publication number
ES436458A1
ES436458A1 ES436458A ES436458A ES436458A1 ES 436458 A1 ES436458 A1 ES 436458A1 ES 436458 A ES436458 A ES 436458A ES 436458 A ES436458 A ES 436458A ES 436458 A1 ES436458 A1 ES 436458A1
Authority
ES
Spain
Prior art keywords
digoxin
preparation
alcohol
derivatives
digoxin derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES436458A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE2418127A external-priority patent/DE2418127A1/en
Priority claimed from DE19742433563 external-priority patent/DE2433563C2/en
Application filed by Boehringer Mannheim GmbH filed Critical Boehringer Mannheim GmbH
Publication of ES436458A1 publication Critical patent/ES436458A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J19/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 by a lactone ring
    • C07J19/005—Glycosides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)

Abstract

Procedure for the preparation of C22 alcoholic derivatives of digoxin of the general formula I **(See formula)** in which it means an alcohol group with 1 to 4 carbon atoms, characterized in that digoxin dissolved in a strongly polar aprotic solvent, possibly with intermediate protection of the two hydroxyl groups of the terminal digitoxose, is reacted with a iodide of alcohol in the presence of sodium hydride, and the products of the process are isolated in the usual way. (Machine-translation by Google Translate, not legally binding)
ES436458A 1974-04-13 1975-04-09 Process for the preparation of digoxin derivatives Expired ES436458A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE2418127A DE2418127A1 (en) 1974-04-13 1974-04-13 22-Alkyl digoxin derivs prepn. - from digoxin, alkyl iodide and sodium hydride in aprotic solvent
DE19742433563 DE2433563C2 (en) 1974-07-12 1974-07-12 Process for the preparation of C22-alkyl derivatives of digoxin

Publications (1)

Publication Number Publication Date
ES436458A1 true ES436458A1 (en) 1977-01-01

Family

ID=25766973

Family Applications (1)

Application Number Title Priority Date Filing Date
ES436458A Expired ES436458A1 (en) 1974-04-13 1975-04-09 Process for the preparation of digoxin derivatives

Country Status (9)

Country Link
JP (1) JPS5851960B2 (en)
AR (1) AR202973A1 (en)
CA (1) CA1033714A (en)
ES (1) ES436458A1 (en)
FI (1) FI54317C (en)
FR (1) FR2267328B1 (en)
GB (1) GB1449804A (en)
NL (1) NL7504091A (en)
SE (1) SE396392B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61171714U (en) * 1985-04-12 1986-10-24

Also Published As

Publication number Publication date
SE396392B (en) 1977-09-19
NL7504091A (en) 1975-10-15
FR2267328B1 (en) 1978-06-30
FI54317C (en) 1978-11-10
GB1449804A (en) 1976-09-15
FI751053A (en) 1975-10-14
AU8004375A (en) 1976-10-14
SE7504005L (en) 1975-10-14
JPS50137970A (en) 1975-11-01
CA1033714A (en) 1978-06-27
JPS5851960B2 (en) 1983-11-19
FI54317B (en) 1978-07-31
AR202973A1 (en) 1975-07-31
FR2267328A1 (en) 1975-11-07

Similar Documents

Publication Publication Date Title
ES408274A1 (en) 2-(furfuryl-methyl)-6,7-benzomorphans and acid addition salts thereof
ES436458A1 (en) Process for the preparation of digoxin derivatives
ES8302026A1 (en) 11-Methylene-delta-15 steroids, process for their preparation and pharmaceutical compositions containing them.
ES429020A1 (en) Certain 2-alkyl-5-oxymethylthiazoles
ES410934A1 (en) Indole-carboxylic acid derivatives
ES435204A1 (en) 11{62 -fluoroandrostenes
ES427869A1 (en) 5-phenyl-sulphinyl-2-benzimidazolyl-carbamic acid esters and process for their manufacture
ES308535A1 (en) Procedure for obtaining a 2: 2'-bipiridilo halide. (Machine-translation by Google Translate, not legally binding)
ES402328A1 (en) Preparation of 4-hydroxybenzodioxoles
ES437040A1 (en) A procedure for preparing a derivative of ftalazone. (Machine-translation by Google Translate, not legally binding)
ES423372A1 (en) A procedure for the preparation of a stable composition for its application in the vapor degreasing of metals. (Machine-translation by Google Translate, not legally binding)
Lekomtseva et al. Structure of the xylan from the stems of the cotton plant
ES250985A1 (en) Procedure for the preparation of new derivatives of azepine, basically replaced (Machine-translation by Google Translate, not legally binding)
ES426350A1 (en) Procedure for the preparation of derivatives of pisobutil-phenilactic acid. (Machine-translation by Google Translate, not legally binding)
ES437041A1 (en) A procedure for preparing 1-ftalazone derivatives. (Machine-translation by Google Translate, not legally binding)
ES385084A1 (en) Novel glucuronic acid derivatives and process for the preparation thereof
ES398340A1 (en) Method of preparing acid derivatives 8-alcohil-5,8-dihydro-5-oxopiride (2,3-d) pyrimidin-6-carboxylic disused in the position 2. (Machine-translation by Google Translate, not legally binding)
ES380392A1 (en) Procedure for the preparation of a compound of 5-nitro-furil-pirazol. (Machine-translation by Google Translate, not legally binding)
ES386181A2 (en) Procedure for the preparation of diglicidyl eteres. (Machine-translation by Google Translate, not legally binding)
ES445254A1 (en) A procedure for the preparation of 3-substitute methyl-2 or 3-cefem-4-carboxylic acids. (Machine-translation by Google Translate, not legally binding)
ES431523A1 (en) A procedure for preparing a derivative of ftalazone. (Machine-translation by Google Translate, not legally binding)
ES384815A1 (en) A procedure for the preparation of nicotinates and N-oxido-nicotinates of aliphatic amines. (Machine-translation by Google Translate, not legally binding)
ES459574A3 (en) Procedure for the preparation of new indel derivatives. (Machine-translation by Google Translate, not legally binding)
ES423973A1 (en) Procedure for the preparation of new bencilamines. (Machine-translation by Google Translate, not legally binding)
ES369000A2 (en) A method of preparing polycarboxylates. (Machine-translation by Google Translate, not legally binding)