ES435950A1 - Procedimiento de preparacion de acidos 4-aril-4-oxo-2-me- til-2-butenoicos y sus derivados amidicos. - Google Patents

Procedimiento de preparacion de acidos 4-aril-4-oxo-2-me- til-2-butenoicos y sus derivados amidicos.

Info

Publication number
ES435950A1
ES435950A1 ES435950A ES435950A ES435950A1 ES 435950 A1 ES435950 A1 ES 435950A1 ES 435950 A ES435950 A ES 435950A ES 435950 A ES435950 A ES 435950A ES 435950 A1 ES435950 A1 ES 435950A1
Authority
ES
Spain
Prior art keywords
keto acids
reducing cholesterol
certain aromatic
aromatic keto
certain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES435950A
Other languages
English (en)
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pierre Fabre SA
Original Assignee
Pierre Fabre SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR7410196A external-priority patent/FR2265409A1/fr
Priority claimed from FR7504912A external-priority patent/FR2300551A2/fr
Application filed by Pierre Fabre SA filed Critical Pierre Fabre SA
Publication of ES435950A1 publication Critical patent/ES435950A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/84—Unsaturated compounds containing keto groups containing six membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/86—Unsaturated compounds containing keto groups containing six-membered aromatic rings and other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/88—Unsaturated compounds containing keto groups containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/90—Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
ES435950A 1974-03-25 1975-03-24 Procedimiento de preparacion de acidos 4-aril-4-oxo-2-me- til-2-butenoicos y sus derivados amidicos. Expired ES435950A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR7410196A FR2265409A1 (en) 1974-03-25 1974-03-25 4-Oxo-4-phenyl-2-methyl(ene)-butyric acid derivs. - analgesics, antiinflammatories and hypocholesterolemiants
FR7504912A FR2300551A2 (fr) 1975-02-17 1975-02-17 Nouveaux

Publications (1)

Publication Number Publication Date
ES435950A1 true ES435950A1 (es) 1976-12-16

Family

ID=26218246

Family Applications (2)

Application Number Title Priority Date Filing Date
ES435949A Expired ES435949A1 (es) 1974-03-25 1975-03-24 Procedimiento de prepracion de acidos 4-aril-4-oxo-2-meti- len-butricos.
ES435950A Expired ES435950A1 (es) 1974-03-25 1975-03-24 Procedimiento de preparacion de acidos 4-aril-4-oxo-2-me- til-2-butenoicos y sus derivados amidicos.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES435949A Expired ES435949A1 (es) 1974-03-25 1975-03-24 Procedimiento de prepracion de acidos 4-aril-4-oxo-2-meti- len-butricos.

Country Status (5)

Country Link
US (1) US4008323A (en:Method)
CH (2) CH595322A5 (en:Method)
DE (1) DE2513157A1 (en:Method)
ES (2) ES435949A1 (en:Method)
GB (1) GB1498903A (en:Method)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4271191A (en) * 1979-12-19 1981-06-02 Pierre Fabre S.A. Method of treating hyperuricemia and gout
FR2515037A1 (fr) * 1981-10-22 1983-04-29 Roussel Uclaf A titre de medicaments, certains derives mono-substitues de l'acide 4-phenyl 4-oxo buten-2-oique, ainsi que les compositions les renfermant
US4667055A (en) * 1983-12-29 1987-05-19 Merck Frosst Canada, Inc. Leukotriene antagonists
US4871756A (en) * 1985-03-20 1989-10-03 Merck Frosst Canada, Inc. Leukotriene antagonists
US5157022A (en) * 1989-11-22 1992-10-20 Adrian Barbul Method for reducing blood cholesterol using arginine
US5280045A (en) * 1991-10-16 1994-01-18 The Procter & Gamble Company 4(3,5-bis(1,1-dimethylethyl-4-hydroxyphenyl)-4-oxobutanamide compound useful as an anti-inflammatory agent
US7910624B1 (en) 1995-03-03 2011-03-22 The Trustees Of Boston University Compositions for the treatment of blood disorders
EP0731712A4 (en) * 1993-10-29 2005-11-09 Univ Boston PHYSIOLOGICALLY STABLE COMPOSITIONS OF BUTYRIC ACID, SALTS AND BUTYRIC ACID DERIVATIVES AS ANTINEOPLASTIC AGENTS
HRP950558A2 (en) * 1994-11-15 1997-12-31 Scott M. Wilhelm Substituted 4-biarylbutric or biarylpentanoic acids and derivatives as matrix metalloprotease inhibitors
US5789434A (en) * 1994-11-15 1998-08-04 Bayer Corporation Derivatives of substituted 4-biarylbutyric acid as matrix metalloprotease inhibitors
US6011000A (en) * 1995-03-03 2000-01-04 Perrine; Susan P. Compositions for the treatment of blood disorders
GB9522617D0 (en) * 1995-11-03 1996-01-03 Pharmacia Spa 4-Phenyl-4-oxo-butenoic acid derivatives with kynurenine-3-hydroxylase inhibiting activity
GB9522615D0 (en) * 1995-11-03 1996-01-03 Pharmacia Spa 4-Phenyl-4-oxo-butanoic acid derivatives with kynurenine-3-hydroxylase inhibiting activity
CA2304713C (en) 1997-10-14 2003-06-10 Asahi Kasei Kogyo Kabushiki Kaisha Biphenyl-5-alkanoic acid derivatives and use thereof
AU774861B2 (en) * 1998-02-11 2004-07-08 Douglas V Faller Compositions and methods for the treatment of cystic fibrosis
DE19835359A1 (de) * 1998-08-05 2000-02-10 Clariant Gmbh Verfahren zur Herstellung von 4-(4'-Chlorbiphenyl-4-yl)-4-keto-2-methylenbuttersäure
CA2503284A1 (en) * 2002-10-24 2004-05-06 Enos Pharmaceuticals, Inc. Sustained release l-arginine formulations and methods of manufacture and use
US20080145424A1 (en) * 2002-10-24 2008-06-19 Enos Phramaceuticals, Inc. Sustained release L-arginine formulations and methods of manufacture and use
AU2004279298B2 (en) * 2003-09-29 2009-01-29 Palmetto Pharmaceuticals, Llc Sustained release L-arginine formulations and methods of manufacture and use
WO2010105112A1 (en) * 2009-03-11 2010-09-16 Hemaquest Pharmaceuticals, Inc. Detection of short-chain fatty acids in biological samples
US20110086869A1 (en) 2009-09-24 2011-04-14 The Trustees Of Boston University Methods for treating viral disorders
EP2509418A4 (en) 2009-12-08 2013-03-20 Hemaquest Pharmaceuticals Inc METHOD AND LOW DOSAGE SCHEMES FOR THE TREATMENT OF ERYTHROCYTE DYSFUNCTION
WO2011113013A2 (en) 2010-03-11 2011-09-15 Hemaquest Pharmaceuticals, Inc. Methods and compositions for treating viral or virally-induced conditions
WO2018013975A1 (en) 2016-07-15 2018-01-18 Viracta Therapeutics, Inc. Hdac inhibitors for use with nk cell based therapies
KR20220034736A (ko) 2019-05-31 2022-03-18 비락타 서브시디어리 인크. 히스톤 데아세틸라제 억제제를 사용하여 바이러스 관련 암을 치료하는 방법

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3452081A (en) * 1965-05-27 1969-06-24 Merck & Co Inc Phenoxy substituted 2-alkenoic acids
BE708617A (en:Method) 1966-12-30 1968-06-28
US3754021A (en) * 1968-05-29 1973-08-21 Merck & Co Inc 4-keto-4-(3-chloro-4'-cyclohexyl)phenylbutyric acid and related compounds
US3919304A (en) * 1968-10-25 1975-11-11 Ciba Geigy Corp {62 -Hydroxy-{62 -(cycloalkenylphenyl)alkanoic acids, esters and salts
BE759053A (fr) * 1969-11-17 1971-05-17 Thomae Gmbh Dr K Nouveaux acides hydroxycrotoniques et procedes pour les fabriquer
US3784701A (en) * 1970-09-21 1974-01-08 American Cyanamid Co Compositions containing substituted benzoylpropionic acids and method of use to treat inflammation and pain
DE2103749A1 (en) * 1971-01-27 1972-08-10 Dr. Karl Thomae GmbH, 7951 Biberach 3-acyl-acrylic acids prepn - from a ketone and glyoxylic acid (deriv)
BE788749A (fr) * 1971-09-13 1973-03-13 Takeda Chemical Industries Ltd Acide 3-(benzoyl trisubstitue)-propionique et son procede de preparation
US3860722A (en) * 1972-09-22 1975-01-14 Richardson Merrell Inc Hypolipidemic agents

Also Published As

Publication number Publication date
DE2513157C2 (en:Method) 1987-12-10
CH596130A5 (en:Method) 1978-02-28
CH595322A5 (en:Method) 1978-02-15
DE2513157A1 (de) 1975-10-09
ES435949A1 (es) 1976-12-16
US4008323A (en) 1977-02-15
GB1498903A (en) 1978-01-25

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