ES434971A1 - Pharmaceutical preparations - Google Patents

Pharmaceutical preparations

Info

Publication number
ES434971A1
ES434971A1 ES434971A ES434971A ES434971A1 ES 434971 A1 ES434971 A1 ES 434971A1 ES 434971 A ES434971 A ES 434971A ES 434971 A ES434971 A ES 434971A ES 434971 A1 ES434971 A1 ES 434971A1
Authority
ES
Spain
Prior art keywords
digoxin
capsule
pharmaceutically
sheets
solvent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES434971A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Publication of ES434971A1 publication Critical patent/ES434971A1/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Method of producing a pharmaceutical preparation comprising a solution of digoxin in a soluble capsule shell, in the form of an orally ingestible unit dose pharmaceutical capsule formulation, wherein the amount of digoxin contained within each capsule is the 80% of that conventionally presented as a prior art tablet formulation, characterized in that (a) digoxin is thoroughly and uniformly mixed with a solvent for it, the solvent being pharmaceutically and medicinally acceptable for the gastrointestinal tract of a mammal and not substantially destructive of the capsule shell; (b) the material that constitutes the envelope of the capsule is transformed into two sheets, the material being pharmaceutically and medicinally acceptable for and soluble in the mammalian gastrointestinal tract; and (c) the two sheets of material are marginally welded to each other around a unit dose of the digoxin solution. (Machine-translation by Google Translate, not legally binding)
ES434971A 1974-02-22 1975-02-21 Pharmaceutical preparations Expired ES434971A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US44496174A 1974-02-22 1974-02-22
US45300074A 1974-03-19 1974-03-19

Publications (1)

Publication Number Publication Date
ES434971A1 true ES434971A1 (en) 1977-05-16

Family

ID=27034126

Family Applications (1)

Application Number Title Priority Date Filing Date
ES434971A Expired ES434971A1 (en) 1974-02-22 1975-02-21 Pharmaceutical preparations

Country Status (14)

Country Link
JP (1) JPS50126822A (en)
AU (2) AU501549B2 (en)
CA (1) CA1096307A (en)
DE (1) DE2507635A1 (en)
ES (1) ES434971A1 (en)
FI (1) FI750489A (en)
FR (1) FR2261752B1 (en)
GB (1) GB1506016A (en)
IE (1) IE41620B1 (en)
IL (1) IL46682A (en)
IT (1) IT1233251B (en)
LU (1) LU71894A1 (en)
NL (1) NL7502121A (en)
SE (1) SE426549B (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1508770A (en) * 1974-04-01 1978-04-26 Scherer Ltd R Pharmaceutical compositions
US4002718A (en) * 1974-10-16 1977-01-11 Arnar-Stone Laboratories, Inc. Gelatin-encapsulated digoxin solutions and method of preparing the same
FR2380030A1 (en) * 1977-02-09 1978-09-08 Christiaens Sa A Liquid and solid solns. of gitoxin - with high bio:availability for treating cardiac disorders
IT1158722B (en) * 1977-07-08 1987-02-25 Simes PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF SLEEP TURBES
JPS5625428U (en) * 1979-08-03 1981-03-09
US4366145A (en) * 1981-06-24 1982-12-28 Sandoz, Inc. Soft gelatin capsule with a liquid ergot alkaloid center fill solution and method of preparation
US4994260A (en) * 1982-05-28 1991-02-19 Astra Lakemedel Aktiebolag Pharmaceutical mixture
SE8203953D0 (en) * 1982-06-24 1982-06-24 Astra Laekemedel Ab PHARMACEUTICAL MIXTURE
DE3445237C1 (en) * 1984-12-12 1986-06-05 R.P. Scherer GmbH, 6930 Eberbach Soft gelatin capsules and process for their manufacture
DE3529694A1 (en) * 1985-08-20 1987-02-26 Scherer Gmbh R P GELATINE CAPSULES AND METHOD FOR THEIR PRODUCTION

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1481411A (en) * 1973-07-20 1977-07-27 Scherer Ltd R Pharmaceutical compositions

Also Published As

Publication number Publication date
AU520082B2 (en) 1982-01-14
IE41620B1 (en) 1980-02-13
DE2507635A1 (en) 1975-08-28
FR2261752B1 (en) 1978-07-21
IL46682A (en) 1979-07-25
LU71894A1 (en) 1975-12-09
IL46682A0 (en) 1975-04-25
JPS50126822A (en) 1975-10-06
IE41620L (en) 1975-08-22
NL7502121A (en) 1975-08-26
FI750489A (en) 1975-08-23
SE7501967L (en) 1975-08-25
AU501549B2 (en) 1979-06-21
GB1506016A (en) 1978-04-05
SE426549B (en) 1983-01-31
IT8349395A0 (en) 1983-11-28
IT1233251B (en) 1992-03-24
FR2261752A1 (en) 1975-09-19
DE2507635C2 (en) 1991-07-25
CA1096307A (en) 1981-02-24
AU7844075A (en) 1976-08-26

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19980401