ES431672A1 - Polymorphic form of a dibenzopyranone - Google Patents
Polymorphic form of a dibenzopyranoneInfo
- Publication number
- ES431672A1 ES431672A1 ES431672A ES431672A ES431672A1 ES 431672 A1 ES431672 A1 ES 431672A1 ES 431672 A ES431672 A ES 431672A ES 431672 A ES431672 A ES 431672A ES 431672 A1 ES431672 A1 ES 431672A1
- Authority
- ES
- Spain
- Prior art keywords
- dimethylheptyl
- dibenzo
- hexahydro
- hydroxy
- dimethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/78—Ring systems having three or more relevant rings
- C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
Abstract
A process for preparing a novel, stable polymorphic form of 1-hydroxy-3- (1 ', 1'-dimethylheptyl) -6,6-dimethyl-6,6a, 7,8,10,10a-hexahydro-9h- dibenzo [b, d] pyran-9-ona which has the following physical characteristics: shows birefringence under a polarization microscope, shows endotherms under differential thermal analysis at 156ºC and 162º c, and has the following powder diffraction pattern of x-rays using filtered erominium radiation having a wavelength of 2.2896 å. "d" and å ii/i 14.5 100 10.5 30 8,4 60 7,2 40 6,50 20 5,90 30 4,85 60 "d" and å i/io 4,10 05 3,90 40 3,35 30 Characterized by A) dissolve 1-hydroxy-3- (1 ', 1'-dimethylheptyl) -6,6-dimethyl-6,6a, 7,8,10,10a-hexahydro-9h-dibenzo [b, dpyran-9- one in ethanol; B) adding the ethanolic solution, with agitation at a speed exceeding 300 revolutions per minute, to a volume of water at least 25 times greater than the volume of the ethanolic solution; y C) collecting the crystalline product precipitated by conventional methods. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41301173A | 1973-11-05 | 1973-11-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES431672A1 true ES431672A1 (en) | 1977-04-16 |
Family
ID=23635422
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES431672A Expired ES431672A1 (en) | 1973-11-05 | 1974-10-05 | Polymorphic form of a dibenzopyranone |
Country Status (24)
| Country | Link |
|---|---|
| JP (1) | JPS5943463B2 (en) |
| AR (1) | AR202670A1 (en) |
| AT (1) | AT335453B (en) |
| BE (1) | BE821720A (en) |
| BG (1) | BG27088A3 (en) |
| CA (1) | CA1028715A (en) |
| CS (1) | CS174793B2 (en) |
| DD (1) | DD115660A5 (en) |
| DE (1) | DE2449927C2 (en) |
| DK (1) | DK136720B (en) |
| ES (1) | ES431672A1 (en) |
| FR (1) | FR2249665B1 (en) |
| GB (1) | GB1487635A (en) |
| HU (1) | HU167751B (en) |
| IE (1) | IE39678B1 (en) |
| IL (1) | IL45742A (en) |
| NL (1) | NL7412682A (en) |
| PH (1) | PH11719A (en) |
| PL (1) | PL94119B1 (en) |
| RO (1) | RO71769A (en) |
| SE (1) | SE407062B (en) |
| SU (1) | SU611591A3 (en) |
| YU (1) | YU287874A (en) |
| ZA (1) | ZA746029B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4278603A (en) * | 1973-11-05 | 1981-07-14 | Eli Lilly And Company | Novel polymorphic crystalline form of dibenzopyranone |
| US4195078A (en) * | 1979-03-09 | 1980-03-25 | Eli Lilly And Company | Nabilone granulation |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3507885A (en) * | 1966-03-25 | 1970-04-21 | Hoffmann La Roche | 3-alkyl-6h-dibenzo(b,d)pyrans |
-
1974
- 1974-09-20 IE IE1949/74A patent/IE39678B1/en unknown
- 1974-09-23 ZA ZA00746029A patent/ZA746029B/en unknown
- 1974-09-25 NL NL7412682A patent/NL7412682A/en not_active Application Discontinuation
- 1974-09-27 PH PH16343A patent/PH11719A/en unknown
- 1974-09-27 IL IL45742A patent/IL45742A/en unknown
- 1974-10-01 CA CA210,510A patent/CA1028715A/en not_active Expired
- 1974-10-05 ES ES431672A patent/ES431672A1/en not_active Expired
- 1974-10-14 SE SE7412921A patent/SE407062B/en unknown
- 1974-10-17 SU SU742069769A patent/SU611591A3/en active
- 1974-10-21 DE DE2449927A patent/DE2449927C2/en not_active Expired
- 1974-10-24 AT AT856674A patent/AT335453B/en not_active IP Right Cessation
- 1974-10-28 YU YU02878/74A patent/YU287874A/en unknown
- 1974-10-31 PL PL1974175276A patent/PL94119B1/pl unknown
- 1974-10-31 FR FR7436368A patent/FR2249665B1/fr not_active Expired
- 1974-10-31 BE BE150088A patent/BE821720A/en not_active IP Right Cessation
- 1974-11-04 CS CS7516A patent/CS174793B2/cs unknown
- 1974-11-04 DD DD182141A patent/DD115660A5/xx unknown
- 1974-11-04 DK DK573374AA patent/DK136720B/en not_active IP Right Cessation
- 1974-11-04 HU HUEI574A patent/HU167751B/hu unknown
- 1974-11-04 GB GB47516/74A patent/GB1487635A/en not_active Expired
- 1974-11-05 BG BG7428123A patent/BG27088A3/xx unknown
- 1974-11-05 RO RO7480429A patent/RO71769A/en unknown
- 1974-11-05 AR AR256414A patent/AR202670A1/en active
- 1974-11-05 JP JP49127923A patent/JPS5943463B2/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| SE7412921L (en) | 1975-05-06 |
| AR202670A1 (en) | 1975-06-30 |
| AU7362674A (en) | 1976-04-01 |
| JPS5082222A (en) | 1975-07-03 |
| GB1487635A (en) | 1977-10-05 |
| BG27088A3 (en) | 1979-08-15 |
| AT335453B (en) | 1977-03-10 |
| SE407062B (en) | 1979-03-12 |
| IL45742A0 (en) | 1974-11-29 |
| ATA856674A (en) | 1976-07-15 |
| NL7412682A (en) | 1975-05-07 |
| YU287874A (en) | 1984-04-30 |
| HU167751B (en) | 1975-12-25 |
| DE2449927C2 (en) | 1985-07-04 |
| FR2249665A1 (en) | 1975-05-30 |
| CA1028715A (en) | 1978-03-28 |
| JPS5943463B2 (en) | 1984-10-22 |
| PH11719A (en) | 1978-05-30 |
| BE821720A (en) | 1975-04-30 |
| SU611591A3 (en) | 1978-06-15 |
| IL45742A (en) | 1978-06-15 |
| DK136720C (en) | 1978-04-24 |
| PL94119B1 (en) | 1977-07-30 |
| CS174793B2 (en) | 1977-04-29 |
| RO71769A (en) | 1981-09-24 |
| IE39678L (en) | 1975-05-05 |
| IE39678B1 (en) | 1978-12-06 |
| DE2449927A1 (en) | 1975-05-07 |
| FR2249665B1 (en) | 1978-07-21 |
| ZA746029B (en) | 1976-04-28 |
| DK573374A (en) | 1975-07-07 |
| DK136720B (en) | 1977-11-14 |
| DD115660A5 (en) | 1975-10-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19980202 |