ES427455A1 - Procedure for the preparation of 2-carbalcoxy-amino-benzymidazol-5 (6) -fenileteres. (Machine-translation by Google Translate, not legally binding) - Google Patents
Procedure for the preparation of 2-carbalcoxy-amino-benzymidazol-5 (6) -fenileteres. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES427455A1 ES427455A1 ES427455A ES427455A ES427455A1 ES 427455 A1 ES427455 A1 ES 427455A1 ES 427455 A ES427455 A ES 427455A ES 427455 A ES427455 A ES 427455A ES 427455 A1 ES427455 A1 ES 427455A1
- Authority
- ES
- Spain
- Prior art keywords
- carbon atoms
- amino
- denotes
- fenileteres
- benzymidazol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
- C07D235/32—Benzimidazole-2-carbamic acids, unsubstituted or substituted; Esters thereof; Thio-analogues thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The novel anthelmintically active 2-carbalkoxy-amino-benzimidazole-5(6)-phenyl ethers and thioethers of the formula I < IMAGE > wherein R1 denotes alkyl having 1 to 4 carbon atoms, R2 and R3 independently of one another each denote hydrogen, hydroxyl, alkoxy having 1 to 4 carbon atoms, halogen, trifluoromethyl, alkyl having 1 to 4 carbon atoms or carbalkoxy having 1 to 4 carbon atoms in the alkoxy radical, R4 denotes hydrogen or chlorine and X denotes oxygen of sulphur, are prepared by reaction of appropriately substituted o-phenylenediamine derivatives with an appropriately substituted dithiomethyleneamino-formic acid ester. The compounds are valuable chemotherapeutics for the control of parasitic diseases in man and animals. They are particularly active against a large number of helminths, for example Haemonchus, Trichostrongylus, Ostertagia, Strongyloides, Cooperia, Chabertia, Oesophagostomum, Hyostrongylus, Ankylostoma, Askaris and Heterakis.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2332343A DE2332343A1 (en) | 1973-06-26 | 1973-06-26 | 2-CARBALCOXY-AMINO-BENZIMIDAZOL-5 (6) PHENYL ETHER, THEIR PRODUCTION AND USE IN AGENTS AGAINST HELMETS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES427455A1 true ES427455A1 (en) | 1976-07-16 |
Family
ID=5885065
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES427455A Expired ES427455A1 (en) | 1973-06-26 | 1974-06-20 | Procedure for the preparation of 2-carbalcoxy-amino-benzymidazol-5 (6) -fenileteres. (Machine-translation by Google Translate, not legally binding) |
Country Status (12)
| Country | Link |
|---|---|
| JP (1) | JPS5758343B2 (en) |
| AT (1) | AT342041B (en) |
| CA (1) | CA1031781A (en) |
| CH (1) | CH614706A5 (en) |
| DE (1) | DE2332343A1 (en) |
| DK (1) | DK341474A (en) |
| ES (1) | ES427455A1 (en) |
| HU (1) | HU168527B (en) |
| IT (1) | IT1056735B (en) |
| NL (1) | NL7408394A (en) |
| SE (1) | SE7408321L (en) |
| YU (1) | YU37147B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0028455A1 (en) * | 1979-10-12 | 1981-05-13 | Imperial Chemical Industries Plc | 5-Phenylselenobenzimidazole derivatives, their preparation and anthelmintic or fasciolicidal compositions containing them |
| GB9900752D0 (en) * | 1999-01-15 | 1999-03-03 | Angiogene Pharm Ltd | Benzimidazole vascular damaging agents |
-
1973
- 1973-06-26 DE DE2332343A patent/DE2332343A1/en active Pending
-
1974
- 1974-06-20 ES ES427455A patent/ES427455A1/en not_active Expired
- 1974-06-21 NL NL7408394A patent/NL7408394A/xx not_active Application Discontinuation
- 1974-06-24 IT IT24345/74A patent/IT1056735B/en active
- 1974-06-25 YU YU1780/74A patent/YU37147B/en unknown
- 1974-06-25 HU HUHO1682A patent/HU168527B/hu unknown
- 1974-06-25 CA CA203,352A patent/CA1031781A/en not_active Expired
- 1974-06-25 AT AT525274A patent/AT342041B/en not_active IP Right Cessation
- 1974-06-25 DK DK341474A patent/DK341474A/da unknown
- 1974-06-25 CH CH871574A patent/CH614706A5/en not_active IP Right Cessation
- 1974-06-25 SE SE7408321A patent/SE7408321L/xx not_active Application Discontinuation
- 1974-06-26 JP JP49073154A patent/JPS5758343B2/ja not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| NL7408394A (en) | 1974-12-30 |
| DK341474A (en) | 1975-03-17 |
| CA1031781A (en) | 1978-05-23 |
| AT342041B (en) | 1978-03-10 |
| HU168527B (en) | 1976-05-28 |
| IT1056735B (en) | 1982-02-20 |
| JPS5040564A (en) | 1975-04-14 |
| DE2332343A1 (en) | 1975-01-16 |
| ATA525274A (en) | 1977-07-15 |
| JPS5758343B2 (en) | 1982-12-09 |
| CH614706A5 (en) | 1979-12-14 |
| SE7408321L (en) | 1974-12-27 |
| YU37147B (en) | 1984-08-31 |
| YU178074A (en) | 1982-06-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19880208 |