ES425235A1 - Procedure for preparation of dibenzociclohepten derivatives. (Machine-translation by Google Translate, not legally binding) - Google Patents

Abstract

A method of preparing compounds of the general formula IV: **(See formula)** wherein R1 and R2, identical or different, represent hydrogen, a halogen atom, an alcohol radical having 1 to 6 carbon atoms, an alkoxy radical having 1 to 6 carbon atoms, a trifluoromethyl radical, or a dialkohylamino group whose alcohol radicals have 1 to 6 carbon atoms, and RV represents a lower alcohol radical containing 1 to 6 carbon atoms, substituted by a halogen or by a group of the formula (see formula), in which X1 represents hydrogen or an alcohol radical containing from 1 to 6 carbon atoms, as well as its salts, characterized by subjecting a dibenzo- [a, d] -cycloheptene, of the general formula IV: **(See formula)** in which R1 and R2 have the aforementioned meaning and n'' represents an integer that can vary from 1 to 6, to the action of a halogenating agent, to obtain the desired compound of formula IV (with RV = - (CH2) n'' - halogen), which, if necessary, can either be salified by the action of a mineral or organic acid, or cleaved by means of a cleaving reagent, or transformed into quaternary ammonium salt by the action of an ester or lower alcohol halide, or react with an amine of the formula (see formula), in which X1 is defined as above, to obtain the desired compound of formula IV (see formula), which may be salified by the action of a mineral or organic acid, or split by means of a doubling reagent, or transformed into quaternary ammonium salt by the action of an ester or an alcohol halide lower. (Machine-translation by Google Translate, not legally binding)