ES424288A1 - Procedure for obtaining imidazoles. (Machine-translation by Google Translate, not legally binding) - Google Patents

Abstract

Procedure for obtaining imidazoles, of formula I **(See formula)** where one of the radicals R1 and R2 is hydrogen or lower alkyl and the other is the nitro group, R3 is lower alkyl, hydroxy-lower alkyl, lower alkoxy-lower alkyl, lower alkyl-sulfonyl-lower alkyl or amino-lower alkyl, R4 is oxo or thioxo, R5 - when R1 signifies the nitro group - is hydrogen, lower alkyl, hydroxy-lower alkyl, lower alkoxy-lower alkyl, amino-lower alkyl, acyl, aryl or a heterocyclic radical or R5 - when Rg is the group nitro - means aryl or a heterocyclic radical, with the exception of a 2-imidazolyl group, if substituted, and alk is lower alkylene, and its salts, S-oxides, sulfones and N-oxides, characterized in that the fact of that a) an imidazole of formula II **(See formula)** where R1 R2 and R3 have the meaning already indicated and X is a reactable esterified hydroxy group, a reactable etherified hydroxy group, a free or etherified mercapto group, an ammonium group or a sulfonyl group, is reacted with a compound of formula III **(See formula)** where R4, R5 and alk have the aforementioned meaning, or b) an imidazole of formula IV **(See formula)** where R3, R4, R5 and alk have the aforementioned meaning and one of the radicals R'1 and R'2 is hydrogen or lower alkyl and, if desired, within the framework of the definition of the final substances are introduced, modified or they divide substituents and/or the mixtures of racemates obtained are separated in the pure racemates and/or the racemates obtained are separated in the optical antipodes and/or the salts obtained are transformed into the free compounds or other salts or free compounds obtained are converted in its salts. (Machine-translation by Google Translate, not legally binding)